Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HYPOXIA_REVIEW |
| Enrichment Score (ES) | -0.5135152 |
| Normalized Enrichment Score (NES) | -1.7649976 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.047225997 |
| FWER p-Value | 0.995 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOS | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 0 | 1.012 | 0.1242 | No |
| 2 | TFRC | TFRC Entrez, Source | transferrin receptor (p90, CD71) | 439 | 0.131 | 0.1073 | No |
| 3 | IGFBP1 | IGFBP1 Entrez, Source | insulin-like growth factor binding protein 1 | 459 | 0.129 | 0.1218 | No |
| 4 | TF | TF Entrez, Source | transferrin | 575 | 0.120 | 0.1278 | No |
| 5 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 766 | 0.108 | 0.1268 | No |
| 6 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 886 | 0.103 | 0.1305 | No |
| 7 | DDIT3 | DDIT3 Entrez, Source | DNA-damage-inducible transcript 3 | 1228 | 0.089 | 0.1157 | No |
| 8 | FGF3 | FGF3 Entrez, Source | fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog) | 1370 | 0.083 | 0.1153 | No |
| 9 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 1769 | 0.073 | 0.0943 | No |
| 10 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 1883 | 0.070 | 0.0944 | No |
| 11 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 2407 | 0.060 | 0.0624 | No |
| 12 | CP | CP Entrez, Source | ceruloplasmin (ferroxidase) | 2438 | 0.060 | 0.0675 | No |
| 13 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 2593 | 0.057 | 0.0629 | No |
| 14 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 2672 | 0.056 | 0.0639 | No |
| 15 | HMOX1 | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 2730 | 0.055 | 0.0663 | No |
| 16 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 3303 | 0.046 | 0.0288 | No |
| 17 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 3532 | 0.042 | 0.0169 | No |
| 18 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 3627 | 0.041 | 0.0149 | No |
| 19 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 4028 | 0.036 | -0.0108 | No |
| 20 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 4268 | 0.033 | -0.0248 | No |
| 21 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 4483 | 0.030 | -0.0372 | No |
| 22 | XRCC6 | XRCC6 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) | 4746 | 0.027 | -0.0536 | No |
| 23 | ANGPT2 | ANGPT2 Entrez, Source | angiopoietin 2 | 5512 | 0.018 | -0.1090 | No |
| 24 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.1289 | No |
| 25 | HK1 | HK1 Entrez, Source | hexokinase 1 | 5904 | 0.014 | -0.1348 | No |
| 26 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 6204 | 0.011 | -0.1560 | No |
| 27 | TH | TH Entrez, Source | tyrosine hydroxylase | 6759 | 0.005 | -0.1972 | No |
| 28 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 6864 | 0.004 | -0.2046 | No |
| 29 | L1CAM | L1CAM Entrez, Source | L1 cell adhesion molecule | 6912 | 0.003 | -0.2078 | No |
| 30 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 7053 | 0.001 | -0.2181 | No |
| 31 | TFF3 | TFF3 Entrez, Source | trefoil factor 3 (intestinal) | 7322 | -0.002 | -0.2381 | No |
| 32 | GAPDH | GAPDH Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase | 7606 | -0.005 | -0.2588 | No |
| 33 | XRCC5 | XRCC5 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | 7688 | -0.006 | -0.2642 | No |
| 34 | IGF2 | IGF2 Entrez, Source | insulin-like growth factor 2 (somatomedin A) | 8017 | -0.010 | -0.2878 | No |
| 35 | JUN | JUN Entrez, Source | jun oncogene | 8081 | -0.010 | -0.2912 | No |
| 36 | EDN2 | EDN2 Entrez, Source | endothelin 2 | 8122 | -0.011 | -0.2929 | No |
| 37 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 8140 | -0.011 | -0.2928 | No |
| 38 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 8185 | -0.012 | -0.2947 | No |
| 39 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 8690 | -0.018 | -0.3305 | No |
| 40 | PGK1 | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 9333 | -0.026 | -0.3756 | No |
| 41 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 9449 | -0.028 | -0.3808 | No |
| 42 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9927 | -0.035 | -0.4124 | No |
| 43 | HK2 | HK2 Entrez, Source | hexokinase 2 | 10644 | -0.048 | -0.4604 | No |
| 44 | BIK | BIK Entrez, Source | BCL2-interacting killer (apoptosis-inducing) | 11095 | -0.058 | -0.4872 | No |
| 45 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 11170 | -0.060 | -0.4855 | No |
| 46 | MIF | MIF Entrez, Source | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 11278 | -0.062 | -0.4860 | No |
| 47 | EPO | EPO Entrez, Source | erythropoietin | 11309 | -0.063 | -0.4805 | No |
| 48 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.4871 | No |
| 49 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11651 | -0.074 | -0.4886 | No |
| 50 | CD99 | CD99 Entrez, Source | CD99 molecule | 11871 | -0.082 | -0.4951 | No |
| 51 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 11945 | -0.085 | -0.4901 | No |
| 52 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 12126 | -0.093 | -0.4923 | No |
| 53 | ENPEP | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 12336 | -0.106 | -0.4950 | No |
| 54 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 12561 | -0.122 | -0.4969 | Yes |
| 55 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 12783 | -0.145 | -0.4957 | Yes |
| 56 | P4HA1 | P4HA1 Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | 12791 | -0.146 | -0.4782 | Yes |
| 57 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 12870 | -0.160 | -0.4645 | Yes |
| 58 | EDN1 | EDN1 Entrez, Source | endothelin 1 | 13031 | -0.199 | -0.4520 | Yes |
| 59 | VIM | VIM Entrez, Source | vimentin | 13040 | -0.204 | -0.4276 | Yes |
| 60 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13142 | -0.253 | -0.4042 | Yes |
| 61 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 13210 | -0.303 | -0.3720 | Yes |
| 62 | ADM | ADM Entrez, Source | adrenomedullin | 13274 | -0.393 | -0.3284 | Yes |
| 63 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13315 | -0.511 | -0.2686 | Yes |
| 64 | PFKP | PFKP Entrez, Source | phosphofructokinase, platelet | 13318 | -0.516 | -0.2054 | Yes |
| 65 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13326 | -0.627 | -0.1289 | Yes |
| 66 | TAGLN | TAGLN Entrez, Source | transgelin | 13341 | -1.059 | 0.0001 | Yes |
