Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | ION_CHANNEL_ACTIVITY |
| Enrichment Score (ES) | 0.42352518 |
| Normalized Enrichment Score (NES) | 1.7960752 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0330206 |
| FWER p-Value | 0.919 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 215 | 0.170 | 0.0166 | Yes |
| 2 | NOX1 | NOX1 Entrez, Source | NADPH oxidase 1 | 373 | 0.139 | 0.0315 | Yes |
| 3 | TRPM2 | TRPM2 Entrez, Source | transient receptor potential cation channel, subfamily M, member 2 | 595 | 0.118 | 0.0376 | Yes |
| 4 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 690 | 0.112 | 0.0523 | Yes |
| 5 | CLCN1 | CLCN1 Entrez, Source | chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) | 713 | 0.111 | 0.0721 | Yes |
| 6 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 774 | 0.108 | 0.0884 | Yes |
| 7 | TRPV2 | TRPV2 Entrez, Source | transient receptor potential cation channel, subfamily V, member 2 | 808 | 0.106 | 0.1065 | Yes |
| 8 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 884 | 0.103 | 0.1208 | Yes |
| 9 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 980 | 0.098 | 0.1326 | Yes |
| 10 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 1373 | 0.083 | 0.1191 | Yes |
| 11 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 1403 | 0.083 | 0.1329 | Yes |
| 12 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 1472 | 0.080 | 0.1432 | Yes |
| 13 | KCNK15 | KCNK15 Entrez, Source | potassium channel, subfamily K, member 15 | 1594 | 0.077 | 0.1490 | Yes |
| 14 | GLRB | GLRB Entrez, Source | glycine receptor, beta | 1617 | 0.077 | 0.1622 | Yes |
| 15 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 1635 | 0.076 | 0.1756 | Yes |
| 16 | TRPV1 | TRPV1 Entrez, Source | transient receptor potential cation channel, subfamily V, member 1 | 1660 | 0.075 | 0.1884 | Yes |
| 17 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 1774 | 0.073 | 0.1939 | Yes |
| 18 | BSND | BSND Entrez, Source | Bartter syndrome, infantile, with sensorineural deafness (Barttin) | 1812 | 0.072 | 0.2050 | Yes |
| 19 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 1827 | 0.072 | 0.2177 | Yes |
| 20 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 1828 | 0.071 | 0.2316 | Yes |
| 21 | ACCN4 | ACCN4 Entrez, Source | amiloride-sensitive cation channel 4, pituitary | 1833 | 0.071 | 0.2450 | Yes |
| 22 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 1871 | 0.071 | 0.2559 | Yes |
| 23 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 1971 | 0.069 | 0.2617 | Yes |
| 24 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 2059 | 0.067 | 0.2680 | Yes |
| 25 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 2156 | 0.065 | 0.2733 | Yes |
| 26 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 2179 | 0.064 | 0.2840 | Yes |
| 27 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 2194 | 0.064 | 0.2954 | Yes |
| 28 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 2288 | 0.062 | 0.3004 | Yes |
| 29 | GLRA1 | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 2320 | 0.062 | 0.3100 | Yes |
| 30 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 2409 | 0.060 | 0.3149 | Yes |
| 31 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 2443 | 0.060 | 0.3240 | Yes |
| 32 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 2467 | 0.059 | 0.3337 | Yes |
| 33 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 2473 | 0.059 | 0.3447 | Yes |
| 34 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 2611 | 0.057 | 0.3453 | Yes |
| 35 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 2759 | 0.054 | 0.3446 | Yes |
| 36 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 2922 | 0.051 | 0.3423 | Yes |
| 37 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3006 | 0.050 | 0.3457 | Yes |
| 38 | GLRA2 | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 3025 | 0.050 | 0.3539 | Yes |
| 39 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 3127 | 0.048 | 0.3556 | Yes |
| 40 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 3213 | 0.047 | 0.3583 | Yes |
| 41 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 3252 | 0.046 | 0.3644 | Yes |
| 42 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 3309 | 0.046 | 0.3690 | Yes |
| 43 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 3318 | 0.046 | 0.3772 | Yes |
| 44 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 3321 | 0.045 | 0.3858 | Yes |
| 45 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 3538 | 0.042 | 0.3777 | Yes |
| 46 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 3598 | 0.042 | 0.3813 | Yes |
| 47 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 3637 | 0.041 | 0.3864 | Yes |
| 48 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 3690 | 0.041 | 0.3903 | Yes |
| 49 | NMUR2 | NMUR2 Entrez, Source | neuromedin U receptor 2 | 3861 | 0.039 | 0.3849 | Yes |
| 50 | TRPV6 | TRPV6 Entrez, Source | transient receptor potential cation channel, subfamily V, member 6 | 3865 | 0.038 | 0.3921 | Yes |
| 51 | CUL5 | CUL5 Entrez, Source | cullin 5 | 3868 | 0.038 | 0.3994 | Yes |
| 52 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 3973 | 0.037 | 0.3986 | Yes |
| 53 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 4005 | 0.036 | 0.4033 | Yes |
| 54 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 4055 | 0.036 | 0.4065 | Yes |
| 55 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 4117 | 0.035 | 0.4086 | Yes |
| 56 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 4260 | 0.033 | 0.4043 | Yes |
| 57 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 4296 | 0.033 | 0.4079 | Yes |
| 58 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 4301 | 0.033 | 0.4139 | Yes |
| 59 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 4340 | 0.032 | 0.4173 | Yes |
| 60 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 4364 | 0.032 | 0.4217 | Yes |
| 61 | TRPV5 | TRPV5 Entrez, Source | transient receptor potential cation channel, subfamily V, member 5 | 4500 | 0.030 | 0.4173 | Yes |
| 62 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 4520 | 0.030 | 0.4216 | Yes |
| 63 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 4570 | 0.029 | 0.4235 | Yes |
| 64 | KCNK10 | KCNK10 Entrez, Source | potassium channel, subfamily K, member 10 | 4698 | 0.028 | 0.4193 | No |
| 65 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 5036 | 0.023 | 0.3983 | No |
| 66 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 5046 | 0.023 | 0.4021 | No |
| 67 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 5066 | 0.023 | 0.4051 | No |
| 68 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 5195 | 0.022 | 0.3996 | No |
| 69 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 5197 | 0.022 | 0.4037 | No |
| 70 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 5220 | 0.021 | 0.4061 | No |
| 71 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 5379 | 0.019 | 0.3979 | No |
| 72 | CLCNKB | CLCNKB Entrez, Source | chloride channel Kb | 5381 | 0.019 | 0.4016 | No |
| 73 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 5549 | 0.018 | 0.3924 | No |
| 74 | TRPM1 | TRPM1 Entrez, Source | transient receptor potential cation channel, subfamily M, member 1 | 5659 | 0.017 | 0.3874 | No |
| 75 | KCNK3 | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 5875 | 0.014 | 0.3739 | No |
| 76 | KCNN2 | KCNN2 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 5943 | 0.013 | 0.3714 | No |
| 77 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 5970 | 0.013 | 0.3719 | No |
| 78 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 6032 | 0.012 | 0.3697 | No |
| 79 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 6182 | 0.011 | 0.3606 | No |
| 80 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 6532 | 0.007 | 0.3356 | No |
| 81 | FXYD3 | FXYD3 Entrez, Source | FXYD domain containing ion transport regulator 3 | 6555 | 0.007 | 0.3353 | No |
| 82 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 6556 | 0.007 | 0.3366 | No |
| 83 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 6733 | 0.005 | 0.3243 | No |
| 84 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 6768 | 0.005 | 0.3226 | No |
| 85 | CLCN3 | CLCN3 Entrez, Source | chloride channel 3 | 6913 | 0.003 | 0.3123 | No |
| 86 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 6925 | 0.003 | 0.3120 | No |
| 87 | CFTR | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 7051 | 0.001 | 0.3028 | No |
| 88 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 7082 | 0.001 | 0.3008 | No |
| 89 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 7136 | 0.001 | 0.2969 | No |
| 90 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 7158 | 0.000 | 0.2953 | No |
| 91 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 7163 | 0.000 | 0.2951 | No |
| 92 | CLCN2 | CLCN2 Entrez, Source | chloride channel 2 | 7332 | -0.002 | 0.2827 | No |
| 93 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 7423 | -0.003 | 0.2765 | No |
| 94 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 7451 | -0.003 | 0.2750 | No |
| 95 | CNGB1 | CNGB1 Entrez, Source | cyclic nucleotide gated channel beta 1 | 7546 | -0.004 | 0.2688 | No |
| 96 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 7817 | -0.007 | 0.2498 | No |
| 97 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 8007 | -0.010 | 0.2373 | No |
| 98 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 8203 | -0.012 | 0.2249 | No |
| 99 | P2RX2 | P2RX2 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 2 | 8229 | -0.012 | 0.2253 | No |
| 100 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 8268 | -0.013 | 0.2249 | No |
| 101 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 8393 | -0.014 | 0.2182 | No |
| 102 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 8439 | -0.015 | 0.2177 | No |
| 103 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 8576 | -0.016 | 0.2106 | No |
| 104 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 8735 | -0.018 | 0.2022 | No |
| 105 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 9027 | -0.022 | 0.1845 | No |
| 106 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 9045 | -0.023 | 0.1876 | No |
| 107 | CNGA3 | CNGA3 Entrez, Source | cyclic nucleotide gated channel alpha 3 | 9345 | -0.027 | 0.1701 | No |
| 108 | FXYD1 | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 9863 | -0.034 | 0.1376 | No |
| 109 | CLCA2 | CLCA2 Entrez, Source | chloride channel, calcium activated, family member 2 | 10051 | -0.038 | 0.1307 | No |
| 110 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 10103 | -0.038 | 0.1343 | No |
| 111 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 10150 | -0.039 | 0.1384 | No |
| 112 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 10154 | -0.039 | 0.1458 | No |
| 113 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 10205 | -0.040 | 0.1498 | No |
| 114 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 10782 | -0.051 | 0.1161 | No |
| 115 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 10839 | -0.052 | 0.1220 | No |
| 116 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 10962 | -0.055 | 0.1234 | No |
| 117 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 11214 | -0.061 | 0.1162 | No |
| 118 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 12347 | -0.107 | 0.0513 | No |
| 119 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 12575 | -0.124 | 0.0580 | No |
