Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | IRITANI_ADPROX_VASC |
| Enrichment Score (ES) | -0.5858748 |
| Normalized Enrichment Score (NES) | -2.1320937 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.003025953 |
| FWER p-Value | 0.026 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 531 | 0.123 | -0.0274 | No |
| 2 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 940 | 0.100 | -0.0479 | No |
| 3 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 1194 | 0.090 | -0.0577 | No |
| 4 | SRPX | SRPX Entrez, Source | sushi-repeat-containing protein, X-linked | 1692 | 0.074 | -0.0875 | No |
| 5 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 1840 | 0.071 | -0.0912 | No |
| 6 | ANPEP | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 1876 | 0.070 | -0.0866 | No |
| 7 | NRCAM | NRCAM Entrez, Source | neuronal cell adhesion molecule | 1953 | 0.069 | -0.0852 | No |
| 8 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 1957 | 0.069 | -0.0782 | No |
| 9 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 2001 | 0.068 | -0.0744 | No |
| 10 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 2163 | 0.065 | -0.0799 | No |
| 11 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 2251 | 0.063 | -0.0800 | No |
| 12 | LPXN | LPXN Entrez, Source | leupaxin | 2384 | 0.061 | -0.0837 | No |
| 13 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 2605 | 0.057 | -0.0944 | No |
| 14 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 2777 | 0.054 | -0.1018 | No |
| 15 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 2779 | 0.054 | -0.0963 | No |
| 16 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 3166 | 0.048 | -0.1205 | No |
| 17 | SLC1A1 | SLC1A1 Entrez, Source | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 3223 | 0.047 | -0.1199 | No |
| 18 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 3505 | 0.043 | -0.1367 | No |
| 19 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 3518 | 0.043 | -0.1331 | No |
| 20 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 3532 | 0.042 | -0.1297 | No |
| 21 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 3927 | 0.037 | -0.1556 | No |
| 22 | PLA2G4A | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 4307 | 0.033 | -0.1809 | No |
| 23 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 4600 | 0.029 | -0.1999 | No |
| 24 | IL4R | IL4R Entrez, Source | interleukin 4 receptor | 4765 | 0.027 | -0.2096 | No |
| 25 | MAPKAPK3 | MAPKAPK3 Entrez, Source | mitogen-activated protein kinase-activated protein kinase 3 | 4926 | 0.025 | -0.2191 | No |
| 26 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 5178 | 0.022 | -0.2358 | No |
| 27 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 5622 | 0.017 | -0.2675 | No |
| 28 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.2795 | No |
| 29 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 6080 | 0.012 | -0.2991 | No |
| 30 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 6150 | 0.011 | -0.3032 | No |
| 31 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 6558 | 0.007 | -0.3332 | No |
| 32 | CTSC | CTSC Entrez, Source | cathepsin C | 6806 | 0.004 | -0.3514 | No |
| 33 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 6864 | 0.004 | -0.3553 | No |
| 34 | BGN | BGN Entrez, Source | biglycan | 7068 | 0.001 | -0.3705 | No |
| 35 | UPP1 | UPP1 Entrez, Source | uridine phosphorylase 1 | 7441 | -0.003 | -0.3983 | No |
| 36 | ICAM2 | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 7616 | -0.005 | -0.4109 | No |
| 37 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 7708 | -0.006 | -0.4172 | No |
| 38 | SORD | SORD Entrez, Source | sorbitol dehydrogenase | 7900 | -0.008 | -0.4308 | No |
| 39 | FAP | FAP Entrez, Source | fibroblast activation protein, alpha | 8035 | -0.010 | -0.4399 | No |
| 40 | JUN | JUN Entrez, Source | jun oncogene | 8081 | -0.010 | -0.4422 | No |
| 41 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 8149 | -0.011 | -0.4461 | No |
| 42 | LTBP2 | LTBP2 Entrez, Source | latent transforming growth factor beta binding protein 2 | 8356 | -0.014 | -0.4602 | No |
| 43 | TFEC | TFEC Entrez, Source | transcription factor EC | 8378 | -0.014 | -0.4604 | No |
| 44 | TXNRD2 | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 8441 | -0.015 | -0.4635 | No |
| 45 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 8549 | -0.016 | -0.4700 | No |
| 46 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 8630 | -0.017 | -0.4742 | No |
| 47 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 8686 | -0.018 | -0.4765 | No |
| 48 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 8726 | -0.018 | -0.4776 | No |
| 49 | PFN2 | PFN2 Entrez, Source | profilin 2 | 8946 | -0.021 | -0.4919 | No |
| 50 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 9093 | -0.023 | -0.5006 | No |
| 51 | SELP | SELP Entrez, Source | selectin P (granule membrane protein 140kDa, antigen CD62) | 9119 | -0.023 | -0.5000 | No |
| 52 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 9376 | -0.027 | -0.5166 | No |
| 53 | SLC6A8 | SLC6A8 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 9691 | -0.032 | -0.5370 | No |
| 54 | ANXA6 | ANXA6 Entrez, Source | annexin A6 | 9885 | -0.035 | -0.5480 | No |
| 55 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 9887 | -0.035 | -0.5445 | No |
| 56 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9927 | -0.035 | -0.5438 | No |
| 57 | SELE | SELE Entrez, Source | selectin E (endothelial adhesion molecule 1) | 10062 | -0.038 | -0.5500 | No |
| 58 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 10094 | -0.038 | -0.5484 | No |
| 59 | CHST1 | CHST1 Entrez, Source | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 10266 | -0.041 | -0.5571 | No |
| 60 | IER3 | IER3 Entrez, Source | immediate early response 3 | 10439 | -0.044 | -0.5655 | No |
| 61 | LYL1 | LYL1 Entrez, Source | lymphoblastic leukemia derived sequence 1 | 10489 | -0.045 | -0.5645 | No |
| 62 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 10564 | -0.046 | -0.5653 | No |
| 63 | MT1A | MT1A Entrez, Source | metallothionein 1A (functional) | 10667 | -0.048 | -0.5680 | No |
| 64 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 10868 | -0.053 | -0.5777 | Yes |
| 65 | NISCH | NISCH Entrez, Source | nischarin | 10900 | -0.054 | -0.5744 | Yes |
| 66 | UCHL1 | UCHL1 Entrez, Source | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 10996 | -0.056 | -0.5758 | Yes |
| 67 | MLLT11 | MLLT11 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 11034 | -0.057 | -0.5728 | Yes |
| 68 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11131 | -0.059 | -0.5740 | Yes |
| 69 | TCN2 | TCN2 Entrez, Source | transcobalamin II; macrocytic anemia | 11172 | -0.060 | -0.5708 | Yes |
| 70 | MVP | MVP Entrez, Source | major vault protein | 11178 | -0.060 | -0.5650 | Yes |
| 71 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 11206 | -0.060 | -0.5608 | Yes |
| 72 | EIF2B2 | EIF2B2 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | 11231 | -0.061 | -0.5563 | Yes |
| 73 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 11295 | -0.062 | -0.5547 | Yes |
| 74 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 11348 | -0.064 | -0.5520 | Yes |
| 75 | PKIA | PKIA Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 11611 | -0.072 | -0.5643 | Yes |
| 76 | CLU | CLU Entrez, Source | clusterin | 11686 | -0.075 | -0.5621 | Yes |
| 77 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 11798 | -0.079 | -0.5624 | Yes |
| 78 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12081 | -0.091 | -0.5742 | Yes |
| 79 | SLC38A6 | SLC38A6 Entrez, Source | solute carrier family 38, member 6 | 12236 | -0.099 | -0.5757 | Yes |
| 80 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 12353 | -0.107 | -0.5733 | Yes |
| 81 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 12374 | -0.109 | -0.5635 | Yes |
| 82 | ARL6IP5 | ARL6IP5 Entrez, Source | ADP-ribosylation-like factor 6 interacting protein 5 | 12496 | -0.117 | -0.5606 | Yes |
| 83 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12665 | -0.131 | -0.5597 | Yes |
| 84 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 12783 | -0.145 | -0.5535 | Yes |
| 85 | NMT2 | NMT2 Entrez, Source | N-myristoyltransferase 2 | 12913 | -0.168 | -0.5459 | Yes |
| 86 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 12977 | -0.184 | -0.5316 | Yes |
| 87 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 12980 | -0.185 | -0.5127 | Yes |
| 88 | AGRIN | AGRIN Entrez, Source | agrin | 13039 | -0.202 | -0.4962 | Yes |
| 89 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 13053 | -0.209 | -0.4756 | Yes |
| 90 | RGS10 | RGS10 Entrez, Source | regulator of G-protein signalling 10 | 13069 | -0.218 | -0.4542 | Yes |
| 91 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 13090 | -0.227 | -0.4323 | Yes |
| 92 | ANXA3 | ANXA3 Entrez, Source | annexin A3 | 13112 | -0.236 | -0.4094 | Yes |
| 93 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 13161 | -0.265 | -0.3856 | Yes |
| 94 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13270 | -0.390 | -0.3534 | Yes |
| 95 | FHL2 | FHL2 Entrez, Source | four and a half LIM domains 2 | 13281 | -0.405 | -0.3123 | Yes |
| 96 | PROCR | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 13292 | -0.436 | -0.2680 | Yes |
| 97 | GBP2 | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 13295 | -0.454 | -0.2212 | Yes |
| 98 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13308 | -0.484 | -0.1720 | Yes |
| 99 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13326 | -0.627 | -0.1084 | Yes |
| 100 | TAGLN | TAGLN Entrez, Source | transgelin | 13341 | -1.059 | 0.0001 | Yes |
