Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | LE_MYELIN_DN |
| Enrichment Score (ES) | 0.4294154 |
| Normalized Enrichment Score (NES) | 1.7110001 |
| Nominal p-value | 0.002770083 |
| FDR q-value | 0.05508988 |
| FWER p-Value | 0.997 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13 | 0.382 | 0.0418 | Yes |
| 2 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 20 | 0.353 | 0.0808 | Yes |
| 3 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 21 | 0.352 | 0.1201 | Yes |
| 4 | ELOVL6 | ELOVL6 Entrez, Source | ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 29 | 0.313 | 0.1546 | Yes |
| 5 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 36 | 0.306 | 0.1883 | Yes |
| 6 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 44 | 0.291 | 0.2204 | Yes |
| 7 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 55 | 0.278 | 0.2507 | Yes |
| 8 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 56 | 0.277 | 0.2817 | Yes |
| 9 | SERPIND1 | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 83 | 0.240 | 0.3066 | Yes |
| 10 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 90 | 0.236 | 0.3325 | Yes |
| 11 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 148 | 0.193 | 0.3498 | Yes |
| 12 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 167 | 0.185 | 0.3691 | Yes |
| 13 | RTN1 | RTN1 Entrez, Source | reticulon 1 | 181 | 0.178 | 0.3880 | Yes |
| 14 | THRSP | THRSP Entrez, Source | thyroid hormone responsive (SPOT14 homolog, rat) | 266 | 0.155 | 0.3990 | Yes |
| 15 | CAT | CAT Entrez, Source | catalase | 391 | 0.137 | 0.4050 | Yes |
| 16 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 827 | 0.106 | 0.3840 | Yes |
| 17 | SNCG | SNCG Entrez, Source | synuclein, gamma (breast cancer-specific protein 1) | 831 | 0.106 | 0.3956 | Yes |
| 18 | FGL2 | FGL2 Entrez, Source | fibrinogen-like 2 | 897 | 0.103 | 0.4022 | Yes |
| 19 | PCYT2 | PCYT2 Entrez, Source | phosphate cytidylyltransferase 2, ethanolamine | 944 | 0.100 | 0.4098 | Yes |
| 20 | MPDZ | MPDZ Entrez, Source | multiple PDZ domain protein | 1036 | 0.096 | 0.4137 | Yes |
| 21 | GJB1 | GJB1 Entrez, Source | gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) | 1107 | 0.093 | 0.4188 | Yes |
| 22 | FGF7 | FGF7 Entrez, Source | fibroblast growth factor 7 (keratinocyte growth factor) | 1152 | 0.091 | 0.4257 | Yes |
| 23 | GFRA1 | GFRA1 Entrez, Source | GDNF family receptor alpha 1 | 1292 | 0.086 | 0.4249 | Yes |
| 24 | ABCB1A | 1357 | 0.084 | 0.4294 | Yes | ||
| 25 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1768 | 0.073 | 0.4066 | No |
| 26 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 1932 | 0.070 | 0.4021 | No |
| 27 | UTRN | UTRN Entrez, Source | utrophin (homologous to dystrophin) | 1942 | 0.069 | 0.4092 | No |
| 28 | S100B | S100B Entrez, Source | S100 calcium binding protein B | 1995 | 0.068 | 0.4129 | No |
| 29 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2668 | 0.056 | 0.3685 | No |
| 30 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 2696 | 0.055 | 0.3726 | No |
| 31 | ERRFI1 | ERRFI1 Entrez, Source | ERBB receptor feedback inhibitor 1 | 2710 | 0.055 | 0.3778 | No |
| 32 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3006 | 0.050 | 0.3611 | No |
| 33 | COX8B | COX8B Entrez, Source | cytochrome c oxidase, subunit 8B pseudogene | 3473 | 0.043 | 0.3309 | No |
| 34 | SLC25A1 | SLC25A1 Entrez, Source | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 3477 | 0.043 | 0.3355 | No |
| 35 | SEMA6C | SEMA6C Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C | 3497 | 0.043 | 0.3389 | No |
| 36 | LASS2 | LASS2 Entrez, Source | LAG1 homolog, ceramide synthase 2 (S. cerevisiae) | 3708 | 0.040 | 0.3275 | No |
| 37 | SCD | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 3852 | 0.039 | 0.3211 | No |
| 38 | MPZ | MPZ Entrez, Source | myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) | 3998 | 0.036 | 0.3142 | No |
| 39 | ABCA2 | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 4027 | 0.036 | 0.3161 | No |
| 40 | CLDN5 | CLDN5 Entrez, Source | claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) | 4162 | 0.034 | 0.3099 | No |
| 41 | S100A1 | S100A1 Entrez, Source | S100 calcium binding protein A1 | 4459 | 0.030 | 0.2909 | No |
| 42 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 4483 | 0.030 | 0.2926 | No |
| 43 | MBP | MBP Entrez, Source | myelin basic protein | 4867 | 0.026 | 0.2666 | No |
| 44 | ADIPOQ | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 5211 | 0.021 | 0.2431 | No |
| 45 | TKT | TKT Entrez, Source | transketolase (Wernicke-Korsakoff syndrome) | 5330 | 0.020 | 0.2364 | No |
| 46 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | 0.2026 | No |
| 47 | FTH1 | FTH1 Entrez, Source | ferritin, heavy polypeptide 1 | 6227 | 0.011 | 0.1718 | No |
| 48 | TMEM30A | TMEM30A Entrez, Source | transmembrane protein 30A | 6439 | 0.008 | 0.1568 | No |
| 49 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 6558 | 0.007 | 0.1487 | No |
| 50 | PMP22 | PMP22 Entrez, Source | peripheral myelin protein 22 | 6574 | 0.007 | 0.1483 | No |
| 51 | EMP2 | EMP2 Entrez, Source | epithelial membrane protein 2 | 6612 | 0.006 | 0.1463 | No |
| 52 | MAL | MAL Entrez, Source | mal, T-cell differentiation protein | 6779 | 0.004 | 0.1342 | No |
| 53 | NR4A2 | NR4A2 Entrez, Source | nuclear receptor subfamily 4, group A, member 2 | 6791 | 0.004 | 0.1339 | No |
| 54 | PTGDS | PTGDS Entrez, Source | prostaglandin D2 synthase 21kDa (brain) | 6985 | 0.002 | 0.1196 | No |
| 55 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 7451 | -0.003 | 0.0849 | No |
| 56 | ZBTB16 | ZBTB16 Entrez, Source | zinc finger and BTB domain containing 16 | 7635 | -0.005 | 0.0716 | No |
| 57 | FUT8 | FUT8 Entrez, Source | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 7725 | -0.006 | 0.0656 | No |
| 58 | CLTB | CLTB Entrez, Source | clathrin, light chain (Lcb) | 8851 | -0.020 | -0.0170 | No |
| 59 | SULT1A1 | SULT1A1 Entrez, Source | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 8858 | -0.020 | -0.0152 | No |
| 60 | LPL | LPL Entrez, Source | lipoprotein lipase | 8894 | -0.020 | -0.0156 | No |
| 61 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 9449 | -0.028 | -0.0542 | No |
| 62 | MYO1B | MYO1B Entrez, Source | myosin IB | 9460 | -0.028 | -0.0518 | No |
| 63 | PCMT1 | PCMT1 Entrez, Source | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 10054 | -0.038 | -0.0923 | No |
| 64 | SLC6A15 | SLC6A15 Entrez, Source | solute carrier family 6, member 15 | 10453 | -0.044 | -0.1173 | No |
| 65 | CMTM6 | CMTM6 Entrez, Source | CKLF-like MARVEL transmembrane domain containing 6 | 10503 | -0.045 | -0.1160 | No |
| 66 | EPHB6 | EPHB6 Entrez, Source | EPH receptor B6 | 10575 | -0.046 | -0.1161 | No |
| 67 | MYO1D | MYO1D Entrez, Source | myosin ID | 10734 | -0.050 | -0.1224 | No |
| 68 | ADAM10 | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 11154 | -0.059 | -0.1474 | No |
| 69 | BTBD14A | BTBD14A Entrez, Source | BTB (POZ) domain containing 14A | 11489 | -0.068 | -0.1650 | No |
| 70 | SLC1A5 | SLC1A5 Entrez, Source | solute carrier family 1 (neutral amino acid transporter), member 5 | 11601 | -0.072 | -0.1653 | No |
| 71 | SLCO3A1 | SLCO3A1 Entrez, Source | solute carrier organic anion transporter family, member 3A1 | 12233 | -0.099 | -0.2018 | No |
| 72 | FGF1 | FGF1 Entrez, Source | fibroblast growth factor 1 (acidic) | 12602 | -0.125 | -0.2156 | No |
| 73 | SIRT2 | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 12702 | -0.135 | -0.2079 | No |
| 74 | OSBPL5 | OSBPL5 Entrez, Source | oxysterol binding protein-like 5 | 12869 | -0.160 | -0.2026 | No |
| 75 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 13210 | -0.303 | -0.1943 | No |
| 76 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13239 | -0.335 | -0.1589 | No |
| 77 | LOX | LOX Entrez, Source | lysyl oxidase | 13251 | -0.352 | -0.1204 | No |
| 78 | PEA15 | PEA15 Entrez, Source | phosphoprotein enriched in astrocytes 15 | 13282 | -0.412 | -0.0766 | No |
| 79 | CA3 | CA3 Entrez, Source | carbonic anhydrase III, muscle specific | 13332 | -0.725 | 0.0008 | No |
