Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY |
| Enrichment Score (ES) | 0.3583815 |
| Normalized Enrichment Score (NES) | 1.5057845 |
| Nominal p-value | 0.013850415 |
| FDR q-value | 0.1428024 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 215 | 0.170 | 0.0147 | Yes |
| 2 | SLC11A2 | SLC11A2 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 381 | 0.138 | 0.0274 | Yes |
| 3 | TRPM2 | TRPM2 Entrez, Source | transient receptor potential cation channel, subfamily M, member 2 | 595 | 0.118 | 0.0328 | Yes |
| 4 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 690 | 0.112 | 0.0462 | Yes |
| 5 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 774 | 0.108 | 0.0595 | Yes |
| 6 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 884 | 0.103 | 0.0701 | Yes |
| 7 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 980 | 0.098 | 0.0809 | Yes |
| 8 | ITPR1 | ITPR1 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 1 | 1000 | 0.098 | 0.0972 | Yes |
| 9 | ABCB11 | ABCB11 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | 1369 | 0.083 | 0.0846 | Yes |
| 10 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 1373 | 0.083 | 0.0995 | Yes |
| 11 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 1403 | 0.083 | 0.1124 | Yes |
| 12 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 1472 | 0.080 | 0.1219 | Yes |
| 13 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 1635 | 0.076 | 0.1235 | Yes |
| 14 | TRPV1 | TRPV1 Entrez, Source | transient receptor potential cation channel, subfamily V, member 1 | 1660 | 0.075 | 0.1354 | Yes |
| 15 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 1774 | 0.073 | 0.1401 | Yes |
| 16 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 1827 | 0.072 | 0.1492 | Yes |
| 17 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 1828 | 0.071 | 0.1622 | Yes |
| 18 | ACCN4 | ACCN4 Entrez, Source | amiloride-sensitive cation channel 4, pituitary | 1833 | 0.071 | 0.1749 | Yes |
| 19 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 1871 | 0.071 | 0.1850 | Yes |
| 20 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 1971 | 0.069 | 0.1900 | Yes |
| 21 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 2059 | 0.067 | 0.1956 | Yes |
| 22 | CCS | CCS Entrez, Source | copper chaperone for superoxide dismutase | 2069 | 0.066 | 0.2070 | Yes |
| 23 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 2156 | 0.065 | 0.2123 | Yes |
| 24 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 2179 | 0.064 | 0.2223 | Yes |
| 25 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 2194 | 0.064 | 0.2330 | Yes |
| 26 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 2288 | 0.062 | 0.2373 | Yes |
| 27 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 2409 | 0.060 | 0.2392 | Yes |
| 28 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 2443 | 0.060 | 0.2475 | Yes |
| 29 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 2467 | 0.059 | 0.2566 | Yes |
| 30 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 2473 | 0.059 | 0.2669 | Yes |
| 31 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 2611 | 0.057 | 0.2669 | Yes |
| 32 | CLDN16 | CLDN16 Entrez, Source | claudin 16 | 2716 | 0.055 | 0.2691 | Yes |
| 33 | ATP2A1 | ATP2A1 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 2732 | 0.055 | 0.2779 | Yes |
| 34 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 2759 | 0.054 | 0.2858 | Yes |
| 35 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 2922 | 0.051 | 0.2829 | Yes |
| 36 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3006 | 0.050 | 0.2857 | Yes |
| 37 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 3127 | 0.048 | 0.2854 | Yes |
| 38 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 3213 | 0.047 | 0.2875 | Yes |
| 39 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 3252 | 0.046 | 0.2931 | Yes |
| 40 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 3309 | 0.046 | 0.2972 | Yes |
| 41 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 3318 | 0.046 | 0.3049 | Yes |
| 42 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 3321 | 0.045 | 0.3130 | Yes |
| 43 | ITPR2 | ITPR2 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 2 | 3468 | 0.043 | 0.3099 | Yes |
| 44 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 3538 | 0.042 | 0.3124 | Yes |
| 45 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 3598 | 0.042 | 0.3155 | Yes |
| 46 | SLC31A1 | SLC31A1 Entrez, Source | solute carrier family 31 (copper transporters), member 1 | 3616 | 0.042 | 0.3218 | Yes |
| 47 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 3637 | 0.041 | 0.3278 | Yes |
| 48 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 3690 | 0.041 | 0.3313 | Yes |
| 49 | TRPV6 | TRPV6 Entrez, Source | transient receptor potential cation channel, subfamily V, member 6 | 3865 | 0.038 | 0.3251 | Yes |
| 50 | CUL5 | CUL5 Entrez, Source | cullin 5 | 3868 | 0.038 | 0.3320 | Yes |
| 51 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 3973 | 0.037 | 0.3308 | Yes |
| 52 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 4005 | 0.036 | 0.3351 | Yes |
| 53 | ATP2B3 | ATP2B3 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 3 | 4017 | 0.036 | 0.3408 | Yes |
| 54 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 4055 | 0.036 | 0.3445 | Yes |
| 55 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 4117 | 0.035 | 0.3463 | Yes |
| 56 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 4260 | 0.033 | 0.3416 | Yes |
| 57 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 4296 | 0.033 | 0.3448 | Yes |
| 58 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 4301 | 0.033 | 0.3505 | Yes |
| 59 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 4340 | 0.032 | 0.3535 | Yes |
| 60 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 4364 | 0.032 | 0.3575 | Yes |
| 61 | TRPV5 | TRPV5 Entrez, Source | transient receptor potential cation channel, subfamily V, member 5 | 4500 | 0.030 | 0.3528 | Yes |
| 62 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 4520 | 0.030 | 0.3568 | Yes |
| 63 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 4570 | 0.029 | 0.3584 | Yes |
| 64 | KCNK10 | KCNK10 Entrez, Source | potassium channel, subfamily K, member 10 | 4698 | 0.028 | 0.3538 | No |
| 65 | ATP2A3 | ATP2A3 Entrez, Source | ATPase, Ca++ transporting, ubiquitous | 4871 | 0.026 | 0.3454 | No |
| 66 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 5036 | 0.023 | 0.3373 | No |
| 67 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 5046 | 0.023 | 0.3409 | No |
| 68 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 5066 | 0.023 | 0.3436 | No |
| 69 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 5195 | 0.022 | 0.3379 | No |
| 70 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 5197 | 0.022 | 0.3417 | No |
| 71 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 5220 | 0.021 | 0.3439 | No |
| 72 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 5379 | 0.019 | 0.3355 | No |
| 73 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 5549 | 0.018 | 0.3260 | No |
| 74 | SLC30A3 | SLC30A3 Entrez, Source | solute carrier family 30 (zinc transporter), member 3 | 5586 | 0.017 | 0.3264 | No |
| 75 | TRPM1 | TRPM1 Entrez, Source | transient receptor potential cation channel, subfamily M, member 1 | 5659 | 0.017 | 0.3239 | No |
| 76 | KCNK3 | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 5875 | 0.014 | 0.3103 | No |
| 77 | KCNN2 | KCNN2 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 5943 | 0.013 | 0.3076 | No |
| 78 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 5970 | 0.013 | 0.3080 | No |
| 79 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 6032 | 0.012 | 0.3057 | No |
| 80 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 6182 | 0.011 | 0.2965 | No |
| 81 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 6532 | 0.007 | 0.2714 | No |
| 82 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 6556 | 0.007 | 0.2709 | No |
| 83 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 6733 | 0.005 | 0.2585 | No |
| 84 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 6768 | 0.005 | 0.2568 | No |
| 85 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 6925 | 0.003 | 0.2455 | No |
| 86 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 7082 | 0.001 | 0.2339 | No |
| 87 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 7136 | 0.001 | 0.2300 | No |
| 88 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 7158 | 0.000 | 0.2284 | No |
| 89 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 7163 | 0.000 | 0.2282 | No |
| 90 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 7423 | -0.003 | 0.2091 | No |
| 91 | ATP2B4 | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 7434 | -0.003 | 0.2089 | No |
| 92 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 7451 | -0.003 | 0.2083 | No |
| 93 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 7487 | -0.004 | 0.2063 | No |
| 94 | ABCC8 | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 7488 | -0.004 | 0.2069 | No |
| 95 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 7817 | -0.007 | 0.1834 | No |
| 96 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 7838 | -0.008 | 0.1833 | No |
| 97 | SLC8A1 | SLC8A1 Entrez, Source | solute carrier family 8 (sodium/calcium exchanger), member 1 | 7943 | -0.009 | 0.1770 | No |
| 98 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 8007 | -0.010 | 0.1740 | No |
| 99 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 8203 | -0.012 | 0.1614 | No |
| 100 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 8268 | -0.013 | 0.1589 | No |
| 101 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 8393 | -0.014 | 0.1521 | No |
| 102 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 8439 | -0.015 | 0.1514 | No |
| 103 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 8576 | -0.016 | 0.1441 | No |
| 104 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 8735 | -0.018 | 0.1355 | No |
| 105 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 9027 | -0.022 | 0.1175 | No |
| 106 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 9045 | -0.023 | 0.1204 | No |
| 107 | SLC30A4 | SLC30A4 Entrez, Source | solute carrier family 30 (zinc transporter), member 4 | 9378 | -0.027 | 0.1002 | No |
| 108 | ATP2A2 | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 9652 | -0.031 | 0.0853 | No |
| 109 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 10103 | -0.038 | 0.0582 | No |
| 110 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 10150 | -0.039 | 0.0619 | No |
| 111 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 10154 | -0.039 | 0.0689 | No |
| 112 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 10205 | -0.040 | 0.0724 | No |
| 113 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 10318 | -0.042 | 0.0715 | No |
| 114 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 10782 | -0.051 | 0.0458 | No |
| 115 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 10839 | -0.052 | 0.0511 | No |
| 116 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 10962 | -0.055 | 0.0519 | No |
| 117 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 11214 | -0.061 | 0.0440 | No |
| 118 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 11421 | -0.066 | 0.0404 | No |
| 119 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 12347 | -0.107 | -0.0100 | No |
| 120 | SLC31A2 | SLC31A2 Entrez, Source | solute carrier family 31 (copper transporters), member 2 | 13300 | -0.468 | 0.0032 | No |
