Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | NETPATH_ALPHA6_BETA4_INTEGRIN_PATHWAY |
| Enrichment Score (ES) | -0.5183858 |
| Normalized Enrichment Score (NES) | -1.7012885 |
| Nominal p-value | 0.018739352 |
| FDR q-value | 0.06609596 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 233 | 0.163 | 0.0253 | No |
| 2 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 1682 | 0.075 | -0.0640 | No |
| 3 | RTKN | RTKN Entrez, Source | rhotekin | 2071 | 0.066 | -0.0757 | No |
| 4 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 2417 | 0.060 | -0.0859 | No |
| 5 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2668 | 0.056 | -0.0901 | No |
| 6 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2688 | 0.055 | -0.0769 | No |
| 7 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 2931 | 0.051 | -0.0817 | No |
| 8 | PLEC1 | PLEC1 Entrez, Source | plectin 1, intermediate filament binding protein 500kDa | 3180 | 0.048 | -0.0878 | No |
| 9 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 3419 | 0.044 | -0.0941 | No |
| 10 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 3918 | 0.038 | -0.1217 | No |
| 11 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 3943 | 0.037 | -0.1137 | No |
| 12 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 3947 | 0.037 | -0.1042 | No |
| 13 | METAP2 | METAP2 Entrez, Source | methionyl aminopeptidase 2 | 4167 | 0.034 | -0.1117 | No |
| 14 | NTN1 | NTN1 Entrez, Source | netrin 1 | 4762 | 0.027 | -0.1494 | No |
| 15 | EIF4E | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 5790 | 0.015 | -0.2227 | No |
| 16 | RPSA | RPSA Entrez, Source | ribosomal protein SA | 6093 | 0.012 | -0.2422 | No |
| 17 | YWHAE | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 6904 | 0.003 | -0.3024 | No |
| 18 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 7179 | 0.000 | -0.3230 | No |
| 19 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 7310 | -0.002 | -0.3324 | No |
| 20 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8066 | -0.010 | -0.3865 | No |
| 21 | EIF4EBP1 | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 8352 | -0.014 | -0.4043 | No |
| 22 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 8549 | -0.016 | -0.4149 | No |
| 23 | ITGB4BP | ITGB4BP Entrez, Source | integrin beta 4 binding protein | 9616 | -0.031 | -0.4870 | No |
| 24 | YWHAB | YWHAB Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 9932 | -0.035 | -0.5014 | No |
| 25 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 9935 | -0.035 | -0.4923 | No |
| 26 | CLCA2 | CLCA2 Entrez, Source | chloride channel, calcium activated, family member 2 | 10051 | -0.038 | -0.4910 | No |
| 27 | YWHAZ | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 10313 | -0.042 | -0.4997 | No |
| 28 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 10562 | -0.046 | -0.5062 | Yes |
| 29 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 10584 | -0.047 | -0.4955 | Yes |
| 30 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10802 | -0.052 | -0.4983 | Yes |
| 31 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 10906 | -0.054 | -0.4919 | Yes |
| 32 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 10930 | -0.054 | -0.4793 | Yes |
| 33 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10939 | -0.055 | -0.4656 | Yes |
| 34 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 11003 | -0.056 | -0.4556 | Yes |
| 35 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 11055 | -0.057 | -0.4445 | Yes |
| 36 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11131 | -0.059 | -0.4347 | Yes |
| 37 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 11223 | -0.061 | -0.4256 | Yes |
| 38 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11428 | -0.066 | -0.4236 | Yes |
| 39 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11925 | -0.084 | -0.4388 | Yes |
| 40 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 12003 | -0.087 | -0.4217 | Yes |
| 41 | DSP | DSP Entrez, Source | desmoplakin | 12225 | -0.098 | -0.4125 | Yes |
| 42 | YWHAQ | YWHAQ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 12415 | -0.112 | -0.3973 | Yes |
| 43 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 12523 | -0.119 | -0.3740 | Yes |
| 44 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 12535 | -0.120 | -0.3433 | Yes |
| 45 | CD151 | CD151 Entrez, Source | CD151 molecule (Raph blood group) | 12694 | -0.134 | -0.3198 | Yes |
| 46 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12716 | -0.137 | -0.2854 | Yes |
| 47 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12788 | -0.146 | -0.2524 | Yes |
| 48 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13024 | -0.196 | -0.2186 | Yes |
| 49 | VIM | VIM Entrez, Source | vimentin | 13040 | -0.204 | -0.1662 | Yes |
| 50 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 13233 | -0.329 | -0.0943 | Yes |
| 51 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13270 | -0.390 | 0.0054 | Yes |
