Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | NETPATH_EGFR1_PATHWAY_UP |
| Enrichment Score (ES) | -0.46823025 |
| Normalized Enrichment Score (NES) | -1.6940565 |
| Nominal p-value | 0.003164557 |
| FDR q-value | 0.06966102 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GJB2 | GJB2 Entrez, Source | gap junction protein, beta 2, 26kDa (connexin 26) | 123 | 0.205 | 0.0130 | No |
| 2 | FGFBP1 | FGFBP1 Entrez, Source | fibroblast growth factor binding protein 1 | 202 | 0.172 | 0.0259 | No |
| 3 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 351 | 0.142 | 0.0301 | No |
| 4 | TMEM97 | TMEM97 Entrez, Source | transmembrane protein 97 | 492 | 0.126 | 0.0332 | No |
| 5 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 546 | 0.122 | 0.0424 | No |
| 6 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 640 | 0.116 | 0.0480 | No |
| 7 | SOX9 | SOX9 Entrez, Source | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) | 676 | 0.113 | 0.0577 | No |
| 8 | PPAT | PPAT Entrez, Source | phosphoribosyl pyrophosphate amidotransferase | 709 | 0.111 | 0.0674 | No |
| 9 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 825 | 0.106 | 0.0702 | No |
| 10 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 886 | 0.103 | 0.0769 | No |
| 11 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 1194 | 0.090 | 0.0635 | No |
| 12 | DUSP4 | DUSP4 Entrez, Source | dual specificity phosphatase 4 | 1225 | 0.089 | 0.0709 | No |
| 13 | SLC20A1 | SLC20A1 Entrez, Source | solute carrier family 20 (phosphate transporter), member 1 | 1308 | 0.086 | 0.0740 | No |
| 14 | SAA4 | SAA4 Entrez, Source | serum amyloid A4, constitutive | 1457 | 0.081 | 0.0716 | No |
| 15 | FASLG | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 1534 | 0.079 | 0.0744 | No |
| 16 | PPP1R10 | PPP1R10 Entrez, Source | protein phosphatase 1, regulatory subunit 10 | 1553 | 0.078 | 0.0816 | No |
| 17 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 1586 | 0.077 | 0.0876 | No |
| 18 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 1883 | 0.070 | 0.0728 | No |
| 19 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1896 | 0.070 | 0.0796 | No |
| 20 | CORO1A | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 1929 | 0.070 | 0.0847 | No |
| 21 | AREG | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 1977 | 0.069 | 0.0886 | No |
| 22 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 1996 | 0.068 | 0.0947 | No |
| 23 | HAS2 | HAS2 Entrez, Source | hyaluronan synthase 2 | 2122 | 0.065 | 0.0924 | No |
| 24 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 2593 | 0.057 | 0.0631 | No |
| 25 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 2660 | 0.056 | 0.0642 | No |
| 26 | PHLDA1 | PHLDA1 Entrez, Source | pleckstrin homology-like domain, family A, member 1 | 2920 | 0.051 | 0.0502 | No |
| 27 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 2931 | 0.051 | 0.0550 | No |
| 28 | SDC4 | SDC4 Entrez, Source | syndecan 4 (amphiglycan, ryudocan) | 3132 | 0.048 | 0.0452 | No |
| 29 | NOS1 | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 3225 | 0.047 | 0.0433 | No |
| 30 | NOL5A | NOL5A Entrez, Source | nucleolar protein 5A (56kDa with KKE/D repeat) | 3346 | 0.045 | 0.0392 | No |
| 31 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 3472 | 0.043 | 0.0345 | No |
| 32 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 3505 | 0.043 | 0.0367 | No |
| 33 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 3627 | 0.041 | 0.0321 | No |
| 34 | EREG | EREG Entrez, Source | epiregulin | 4157 | 0.034 | -0.0041 | No |
| 35 | PTHLH | PTHLH Entrez, Source | parathyroid hormone-like hormone | 4263 | 0.033 | -0.0085 | No |
| 36 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 4483 | 0.030 | -0.0217 | No |
| 37 | FKBP4 | FKBP4 Entrez, Source | FK506 binding protein 4, 59kDa | 4626 | 0.028 | -0.0294 | No |
| 38 | IL4R | IL4R Entrez, Source | interleukin 4 receptor | 4765 | 0.027 | -0.0369 | No |
| 39 | UBE2N | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 4960 | 0.024 | -0.0489 | No |
| 40 | DUSP1 | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 5117 | 0.022 | -0.0582 | No |
| 41 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 5178 | 0.022 | -0.0604 | No |
| 42 | HNRPAB | HNRPAB Entrez, Source | heterogeneous nuclear ribonucleoprotein A/B | 5269 | 0.021 | -0.0649 | No |
| 43 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 5353 | 0.020 | -0.0691 | No |
| 44 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 5400 | 0.019 | -0.0704 | No |
| 45 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 5628 | 0.017 | -0.0857 | No |
| 46 | EHD1 | EHD1 Entrez, Source | EH-domain containing 1 | 5679 | 0.016 | -0.0877 | No |
| 47 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.0953 | No |
| 48 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 6204 | 0.011 | -0.1244 | No |
| 49 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 6290 | 0.010 | -0.1298 | No |
| 50 | CCNC | CCNC Entrez, Source | cyclin C | 6339 | 0.009 | -0.1324 | No |
| 51 | AKAP12 | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 6511 | 0.007 | -0.1445 | No |
| 52 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 6558 | 0.007 | -0.1472 | No |
| 53 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6937 | 0.003 | -0.1755 | No |
| 54 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 7034 | 0.002 | -0.1826 | No |
| 55 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 7114 | 0.001 | -0.1884 | No |
| 56 | RPL15 | RPL15 Entrez, Source | ribosomal protein L15 | 7516 | -0.004 | -0.2183 | No |
| 57 | COMMD10 | COMMD10 Entrez, Source | COMM domain containing 10 | 7694 | -0.006 | -0.2310 | No |
| 58 | CDK9 | CDK9 Entrez, Source | cyclin-dependent kinase 9 (CDC2-related kinase) | 7702 | -0.006 | -0.2309 | No |
| 59 | MSLN | MSLN Entrez, Source | mesothelin | 7901 | -0.008 | -0.2450 | No |
| 60 | HNRPK | HNRPK Entrez, Source | heterogeneous nuclear ribonucleoprotein K | 7921 | -0.009 | -0.2455 | No |
| 61 | PPP2R1A | PPP2R1A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 8667 | -0.018 | -0.2998 | No |
| 62 | BZW1 | BZW1 Entrez, Source | basic leucine zipper and W2 domains 1 | 9170 | -0.024 | -0.3351 | No |
| 63 | ACOT7 | ACOT7 Entrez, Source | acyl-CoA thioesterase 7 | 9228 | -0.025 | -0.3367 | No |
| 64 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 9887 | -0.035 | -0.3826 | No |
| 65 | UBE2A | UBE2A Entrez, Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 10186 | -0.040 | -0.4008 | No |
| 66 | IER3 | IER3 Entrez, Source | immediate early response 3 | 10439 | -0.044 | -0.4150 | No |
| 67 | ZFP36L2 | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 10449 | -0.044 | -0.4109 | No |
| 68 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 10526 | -0.046 | -0.4117 | No |
| 69 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 10562 | -0.046 | -0.4093 | No |
| 70 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 10703 | -0.049 | -0.4145 | No |
| 71 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 10863 | -0.053 | -0.4207 | No |
| 72 | NR4A3 | NR4A3 Entrez, Source | nuclear receptor subfamily 4, group A, member 3 | 10905 | -0.054 | -0.4180 | No |
| 73 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 11337 | -0.063 | -0.4436 | No |
| 74 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 11349 | -0.064 | -0.4375 | No |
| 75 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11651 | -0.074 | -0.4522 | No |
| 76 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 11785 | -0.078 | -0.4537 | No |
| 77 | SPRY2 | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 11800 | -0.079 | -0.4462 | No |
| 78 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 11843 | -0.081 | -0.4406 | No |
| 79 | PLCG1 | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 11883 | -0.083 | -0.4346 | No |
| 80 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 12330 | -0.106 | -0.4567 | Yes |
| 81 | TUBB | TUBB Entrez, Source | tubulin, beta | 12364 | -0.108 | -0.4475 | Yes |
| 82 | HPCAL1 | HPCAL1 Entrez, Source | hippocalcin-like 1 | 12394 | -0.111 | -0.4376 | Yes |
| 83 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 12427 | -0.112 | -0.4278 | Yes |
| 84 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 12519 | -0.119 | -0.4218 | Yes |
| 85 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 12561 | -0.122 | -0.4116 | Yes |
| 86 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12631 | -0.128 | -0.4029 | Yes |
| 87 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 12783 | -0.145 | -0.3985 | Yes |
| 88 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 12969 | -0.181 | -0.3928 | Yes |
| 89 | HBEGF | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 12974 | -0.182 | -0.3733 | Yes |
| 90 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 13022 | -0.195 | -0.3556 | Yes |
| 91 | VIM | VIM Entrez, Source | vimentin | 13040 | -0.204 | -0.3348 | Yes |
| 92 | ZYX | ZYX Entrez, Source | zyxin | 13115 | -0.238 | -0.3144 | Yes |
| 93 | CAV2 | CAV2 Entrez, Source | caveolin 2 | 13140 | -0.252 | -0.2888 | Yes |
| 94 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13250 | -0.352 | -0.2588 | Yes |
| 95 | GPRC5A | GPRC5A Entrez, Source | G protein-coupled receptor, family C, group 5, member A | 13268 | -0.382 | -0.2186 | Yes |
| 96 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13312 | -0.498 | -0.1677 | Yes |
| 97 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 13313 | -0.503 | -0.1130 | Yes |
| 98 | TAGLN | TAGLN Entrez, Source | transgelin | 13341 | -1.059 | 0.0001 | Yes |
