Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | NETPATH_IL_6_PATHWAY_UP |
| Enrichment Score (ES) | 0.42510664 |
| Normalized Enrichment Score (NES) | 1.5994029 |
| Nominal p-value | 0.008064516 |
| FDR q-value | 0.09378303 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOS | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 0 | 1.012 | 0.1804 | Yes |
| 2 | C4BPB | C4BPB Entrez, Source | complement component 4 binding protein, beta | 22 | 0.342 | 0.2397 | Yes |
| 3 | C4BPA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 79 | 0.243 | 0.2788 | Yes |
| 4 | ZFP36 | ZFP36 Entrez, Source | zinc finger protein 36, C3H type, homolog (mouse) | 141 | 0.196 | 0.3092 | Yes |
| 5 | PPARA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 155 | 0.190 | 0.3421 | Yes |
| 6 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 351 | 0.142 | 0.3527 | Yes |
| 7 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 406 | 0.135 | 0.3726 | Yes |
| 8 | UCP1 | UCP1 Entrez, Source | uncoupling protein 1 (mitochondrial, proton carrier) | 627 | 0.117 | 0.3768 | Yes |
| 9 | CEBPB | CEBPB Entrez, Source | CCAAT/enhancer binding protein (C/EBP), beta | 732 | 0.110 | 0.3886 | Yes |
| 10 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 766 | 0.108 | 0.4054 | Yes |
| 11 | PPARG | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 801 | 0.107 | 0.4219 | Yes |
| 12 | LDLR | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 998 | 0.098 | 0.4246 | Yes |
| 13 | PIM1 | PIM1 Entrez, Source | pim-1 oncogene | 1264 | 0.087 | 0.4202 | Yes |
| 14 | PRKAA1 | PRKAA1 Entrez, Source | protein kinase, AMP-activated, alpha 1 catalytic subunit | 1569 | 0.078 | 0.4112 | Yes |
| 15 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 1769 | 0.073 | 0.4091 | Yes |
| 16 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 2033 | 0.067 | 0.4013 | Yes |
| 17 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 2034 | 0.067 | 0.4133 | Yes |
| 18 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 2175 | 0.064 | 0.4142 | Yes |
| 19 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 2355 | 0.061 | 0.4116 | Yes |
| 20 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 2394 | 0.060 | 0.4195 | Yes |
| 21 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 2558 | 0.058 | 0.4175 | Yes |
| 22 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 2593 | 0.057 | 0.4251 | Yes |
| 23 | MUC5AC | MUC5AC Entrez, Source | mucin 5AC, oligomeric mucus/gel-forming | 2929 | 0.051 | 0.4090 | No |
| 24 | PDGFRA | PDGFRA Entrez, Source | platelet-derived growth factor receptor, alpha polypeptide | 3570 | 0.042 | 0.3683 | No |
| 25 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 4223 | 0.034 | 0.3252 | No |
| 26 | NEU3 | NEU3 Entrez, Source | sialidase 3 (membrane sialidase) | 4971 | 0.024 | 0.2733 | No |
| 27 | EIF5 | EIF5 Entrez, Source | eukaryotic translation initiation factor 5 | 4995 | 0.024 | 0.2758 | No |
| 28 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 5075 | 0.023 | 0.2740 | No |
| 29 | ADIPOQ | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 5211 | 0.021 | 0.2676 | No |
| 30 | ABCC4 | ABCC4 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 5543 | 0.018 | 0.2459 | No |
| 31 | PROS1 | PROS1 Entrez, Source | protein S (alpha) | 5663 | 0.016 | 0.2399 | No |
| 32 | PLA2G2A | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 5884 | 0.014 | 0.2258 | No |
| 33 | CADPS | CADPS Entrez, Source | Ca2+-dependent secretion activator | 6133 | 0.012 | 0.2092 | No |
| 34 | SOCS2 | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 6400 | 0.009 | 0.1907 | No |
| 35 | ABCC5 | ABCC5 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6552 | 0.007 | 0.1806 | No |
| 36 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6778 | 0.004 | 0.1644 | No |
| 37 | JUN | JUN Entrez, Source | jun oncogene | 8081 | -0.010 | 0.0683 | No |
| 38 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 8105 | -0.011 | 0.0684 | No |
| 39 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 8149 | -0.011 | 0.0672 | No |
| 40 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 9067 | -0.023 | 0.0022 | No |
| 41 | MCL1 | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 9085 | -0.023 | 0.0051 | No |
| 42 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 9384 | -0.027 | -0.0125 | No |
| 43 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 9416 | -0.028 | -0.0099 | No |
| 44 | TCF8 | TCF8 Entrez, Source | transcription factor 8 (represses interleukin 2 expression) | 9458 | -0.028 | -0.0079 | No |
| 45 | SOCS1 | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 10039 | -0.037 | -0.0449 | No |
| 46 | CISH | CISH Entrez, Source | cytokine inducible SH2-containing protein | 10352 | -0.042 | -0.0609 | No |
| 47 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 10614 | -0.047 | -0.0721 | No |
| 48 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 11093 | -0.058 | -0.0978 | No |
| 49 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11651 | -0.074 | -0.1265 | No |
| 50 | CLU | CLU Entrez, Source | clusterin | 11686 | -0.075 | -0.1157 | No |
| 51 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 11809 | -0.080 | -0.1107 | No |
| 52 | DCN | DCN Entrez, Source | decorin | 11977 | -0.086 | -0.1079 | No |
| 53 | TNFSF11 | TNFSF11 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 11 | 12167 | -0.095 | -0.1053 | No |
| 54 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 12473 | -0.116 | -0.1076 | No |
| 55 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 12531 | -0.120 | -0.0905 | No |
| 56 | ABCC1 | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 12872 | -0.160 | -0.0875 | No |
| 57 | HBEGF | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 12974 | -0.182 | -0.0626 | No |
| 58 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 12977 | -0.184 | -0.0300 | No |
| 59 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 13226 | -0.322 | 0.0087 | No |
