Details for gene set ORGANIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos
Phenotype	class.cls#double_gel_48h_versus_single_gel_48h_repos
Upregulated in class	double_gel_48h
GeneSet	ORGANIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.5218259
Normalized Enrichment Score (NES)	2.2203963
Nominal p-value	0.0
FDR q-value	4.5362228E-4
FWER p-Value	0.0080

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	12	0.395	0.0358	Yes
2	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	27	0.336	0.0659	Yes
3	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	37	0.303	0.0933	Yes
4	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	54	0.279	0.1180	Yes
5	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	90	0.236	0.1373	Yes
6	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	94	0.229	0.1583	Yes
7	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	102	0.225	0.1786	Yes
8	ARG1	ARG1 Entrez, Source	arginase, liver	117	0.209	0.1969	Yes
9	ACLY	ACLY Entrez, Source	ATP citrate lyase	127	0.202	0.2150	Yes
10	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	155	0.190	0.2307	Yes
11	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	197	0.173	0.2437	Yes
12	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	218	0.170	0.2579	Yes
13	ASL	ASL Entrez, Source	argininosuccinate lyase	273	0.154	0.2681	Yes
14	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	314	0.148	0.2788	Yes
15	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	323	0.146	0.2917	Yes
16	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	362	0.140	0.3019	Yes
17	HDC	HDC Entrez, Source	histidine decarboxylase	383	0.138	0.3132	Yes
18	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	390	0.137	0.3254	Yes
19	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	442	0.130	0.3337	Yes
20	TST	TST Entrez, Source	thiosulfate sulfurtransferase (rhodanese)	446	0.130	0.3455	Yes
21	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	457	0.129	0.3568	Yes
22	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	469	0.128	0.3678	Yes
23	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	476	0.127	0.3792	Yes
24	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	480	0.127	0.3907	Yes
25	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	489	0.126	0.4018	Yes
26	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	494	0.125	0.4131	Yes
27	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	502	0.125	0.4242	Yes
28	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	526	0.123	0.4339	Yes
29	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	591	0.118	0.4400	Yes
30	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	790	0.107	0.4350	Yes
31	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	866	0.104	0.4390	Yes
32	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	877	0.104	0.4478	Yes
33	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	910	0.102	0.4549	Yes
34	SCLY	SCLY Entrez, Source	selenocysteine lyase	1056	0.095	0.4527	Yes
35	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	1097	0.093	0.4584	Yes
36	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	1184	0.090	0.4602	Yes
37	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	1212	0.089	0.4665	Yes
38	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	1237	0.088	0.4729	Yes
39	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	1404	0.082	0.4679	Yes
40	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	1441	0.081	0.4728	Yes
41	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	1493	0.080	0.4763	Yes
42	PAH	PAH Entrez, Source	phenylalanine hydroxylase	1513	0.079	0.4822	Yes
43	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	1528	0.079	0.4884	Yes
44	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	1562	0.078	0.4932	Yes
45	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	1584	0.077	0.4988	Yes
46	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	1625	0.077	0.5028	Yes
47	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	1668	0.075	0.5066	Yes
48	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	1743	0.073	0.5078	Yes
49	PTGES	PTGES Entrez, Source	prostaglandin E synthase	1797	0.072	0.5105	Yes
50	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	1907	0.070	0.5087	Yes
51	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	1932	0.070	0.5134	Yes
52	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	1967	0.069	0.5172	Yes
53	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	2098	0.066	0.5135	Yes
54	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	2116	0.066	0.5183	Yes
55	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	2252	0.063	0.5139	Yes
56	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	2291	0.062	0.5168	Yes
57	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	2302	0.062	0.5218	Yes
58	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	2396	0.060	0.5204	No
59	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	2558	0.058	0.5135	No
60	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	2861	0.052	0.4955	No
61	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	2994	0.050	0.4902	No
62	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	3007	0.050	0.4939	No
63	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	3123	0.048	0.4897	No
64	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	3126	0.048	0.4940	No
65	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	3435	0.044	0.4748	No
66	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	3526	0.043	0.4719	No
67	AMT	AMT Entrez, Source	aminomethyltransferase	3552	0.042	0.4739	No
68	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	3555	0.042	0.4777	No
69	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	3579	0.042	0.4798	No
70	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	3630	0.041	0.4799	No
71	SDS	SDS Entrez, Source	serine dehydratase	3684	0.041	0.4797	No
72	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	3783	0.039	0.4759	No
73	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	3799	0.039	0.4784	No
74	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	3912	0.038	0.4734	No
75	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	3915	0.038	0.4768	No
76	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	3953	0.037	0.4774	No
77	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	4114	0.035	0.4686	No
78	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	4229	0.033	0.4630	No
79	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	4265	0.033	0.4634	No
80	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	4313	0.032	0.4629	No
81	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	4345	0.032	0.4635	No
82	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	4600	0.029	0.4470	No
83	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	4645	0.028	0.4462	No
84	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	4655	0.028	0.4482	No
85	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	4732	0.027	0.4449	No
86	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	4751	0.027	0.4461	No
87	GSS	GSS Entrez, Source	glutathione synthetase	4963	0.024	0.4323	No
88	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	4991	0.024	0.4325	No
89	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	5455	0.019	0.3992	No
90	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	5638	0.017	0.3870	No
91	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	5674	0.016	0.3858	No
92	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	5845	0.014	0.3743	No
93	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	6039	0.012	0.3609	No
94	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	6092	0.012	0.3580	No
95	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	6355	0.009	0.3390	No
96	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	6376	0.009	0.3383	No
97	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	6429	0.008	0.3352	No
98	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	6549	0.007	0.3268	No
99	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	6812	0.004	0.3074	No
100	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	6885	0.003	0.3022	No
101	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	6985	0.002	0.2949	No
102	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	7084	0.001	0.2876	No
103	SLC3A1	SLC3A1 Entrez, Source	1	7608	-0.005	0.2485	No
104	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	7714	-0.006	0.2411	No
105	MPST	MPST Entrez, Source	mercaptopyruvate sulfurtransferase	7835	-0.008	0.2327	No
106	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	7919	-0.009	0.2272	No
107	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	7949	-0.009	0.2258	No
108	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	7995	-0.009	0.2233	No
109	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	8150	-0.011	0.2127	No
110	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	8248	-0.012	0.2065	No
111	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	8367	-0.014	0.1988	No
112	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8545	-0.016	0.1869	No
113	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	8723	-0.018	0.1752	No
114	ARPP-19	ARPP-19 Entrez, Source	-	8985	-0.022	0.1574	No
115	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	9047	-0.023	0.1549	No
116	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	9474	-0.029	0.1253	No
117	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	9724	-0.032	0.1095	No
118	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	9753	-0.033	0.1104	No
119	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	9803	-0.033	0.1098	No
120	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	9958	-0.036	0.1015	No
121	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	10245	-0.041	0.0836	No
122	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	10701	-0.049	0.0537	No
123	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11278	-0.062	0.0158	No
124	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	11526	-0.069	0.0036	No
125	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	12413	-0.112	-0.0531	No
126	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	12539	-0.121	-0.0514	No
127	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	12676	-0.132	-0.0495	No
128	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	12787	-0.146	-0.0442	No
129	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	12793	-0.147	-0.0310	No
130	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	12847	-0.155	-0.0206	No
131	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	12970	-0.181	-0.0131	No
132	SMS	SMS Entrez, Source	spermine synthase	13073	-0.219	-0.0005	No
133	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	13084	-0.224	0.0195	No