Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | P53_SIGNALING |
| Enrichment Score (ES) | -0.5554136 |
| Normalized Enrichment Score (NES) | -1.8456755 |
| Nominal p-value | 0.001572327 |
| FDR q-value | 0.031864002 |
| FWER p-Value | 0.883 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 928 | 0.101 | -0.0473 | No |
| 2 | TEAD1 | TEAD1 Entrez, Source | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 1343 | 0.085 | -0.0596 | No |
| 3 | NDRG2 | NDRG2 Entrez, Source | NDRG family member 2 | 1456 | 0.081 | -0.0500 | No |
| 4 | MAPK8IP2 | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 1589 | 0.077 | -0.0426 | No |
| 5 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 1674 | 0.075 | -0.0322 | No |
| 6 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1896 | 0.070 | -0.0332 | No |
| 7 | NDRG4 | NDRG4 Entrez, Source | NDRG family member 4 | 2272 | 0.063 | -0.0474 | No |
| 8 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 3519 | 0.043 | -0.1316 | No |
| 9 | THRA | THRA Entrez, Source | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | 3546 | 0.042 | -0.1241 | No |
| 10 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 4028 | 0.036 | -0.1523 | No |
| 11 | CCNH | CCNH Entrez, Source | cyclin H | 4088 | 0.035 | -0.1489 | No |
| 12 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 4328 | 0.032 | -0.1597 | No |
| 13 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 4579 | 0.029 | -0.1720 | No |
| 14 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 5178 | 0.022 | -0.2122 | No |
| 15 | SP1 | SP1 Entrez, Source | Sp1 transcription factor | 5193 | 0.022 | -0.2084 | No |
| 16 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 5394 | 0.019 | -0.2191 | No |
| 17 | TBP | TBP Entrez, Source | TATA box binding protein | 5773 | 0.015 | -0.2442 | No |
| 18 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.2430 | No |
| 19 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 6449 | 0.008 | -0.2898 | No |
| 20 | PMP22 | PMP22 Entrez, Source | peripheral myelin protein 22 | 6574 | 0.007 | -0.2976 | No |
| 21 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6778 | 0.004 | -0.3119 | No |
| 22 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 6997 | 0.002 | -0.3279 | No |
| 23 | CSNK2B | CSNK2B Entrez, Source | casein kinase 2, beta polypeptide | 7077 | 0.001 | -0.3336 | No |
| 24 | PPIA | PPIA Entrez, Source | peptidylprolyl isomerase A (cyclophilin A) | 7249 | -0.001 | -0.3463 | No |
| 25 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 7310 | -0.002 | -0.3505 | No |
| 26 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 7431 | -0.003 | -0.3588 | No |
| 27 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 7619 | -0.005 | -0.3718 | No |
| 28 | RPL13A | RPL13A Entrez, Source | ribosomal protein L13a | 7679 | -0.006 | -0.3750 | No |
| 29 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 8442 | -0.015 | -0.4290 | No |
| 30 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 8500 | -0.016 | -0.4298 | No |
| 31 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 8639 | -0.017 | -0.4364 | No |
| 32 | DAXX | DAXX Entrez, Source | death-associated protein 6 | 8710 | -0.018 | -0.4376 | No |
| 33 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8982 | -0.022 | -0.4532 | No |
| 34 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 9024 | -0.022 | -0.4513 | No |
| 35 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.4887 | No |
| 36 | PCAF | PCAF Entrez, Source | p300/CBP-associated factor | 9640 | -0.031 | -0.4837 | No |
| 37 | NUMB | NUMB Entrez, Source | numb homolog (Drosophila) | 9714 | -0.032 | -0.4820 | No |
| 38 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 9720 | -0.032 | -0.4751 | No |
| 39 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 10020 | -0.037 | -0.4894 | No |
| 40 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 10107 | -0.038 | -0.4872 | No |
| 41 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10281 | -0.041 | -0.4911 | No |
| 42 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 10315 | -0.042 | -0.4843 | No |
| 43 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 10437 | -0.044 | -0.4836 | No |
| 44 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 11138 | -0.059 | -0.5231 | Yes |
| 45 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 11170 | -0.060 | -0.5121 | Yes |
| 46 | ACTB | ACTB Entrez, Source | actin, beta | 11264 | -0.061 | -0.5054 | Yes |
| 47 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 11349 | -0.064 | -0.4975 | Yes |
| 48 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 11401 | -0.065 | -0.4867 | Yes |
| 49 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.4795 | Yes |
| 50 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 12064 | -0.090 | -0.5011 | Yes |
| 51 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 12787 | -0.146 | -0.5228 | Yes |
| 52 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12915 | -0.168 | -0.4948 | Yes |
| 53 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 13022 | -0.195 | -0.4591 | Yes |
| 54 | HSPA4 | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 13162 | -0.265 | -0.4103 | Yes |
| 55 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13242 | -0.345 | -0.3392 | Yes |
| 56 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13256 | -0.365 | -0.2587 | Yes |
| 57 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13342 | -1.187 | 0.0000 | Yes |
