Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | REOVIRUS_HEK293_UP |
| Enrichment Score (ES) | -0.46434572 |
| Normalized Enrichment Score (NES) | -1.7370449 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.052483864 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 148 | 0.193 | 0.0108 | No |
| 2 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 269 | 0.155 | 0.0194 | No |
| 3 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 329 | 0.145 | 0.0315 | No |
| 4 | HIST2H2AA3 | HIST2H2AA3 Entrez, Source | histone cluster 2, H2aa3 | 699 | 0.112 | 0.0164 | No |
| 5 | PPAT | PPAT Entrez, Source | phosphoribosyl pyrophosphate amidotransferase | 709 | 0.111 | 0.0284 | No |
| 6 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 766 | 0.108 | 0.0365 | No |
| 7 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 940 | 0.100 | 0.0349 | No |
| 8 | CCL5 | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 1050 | 0.095 | 0.0375 | No |
| 9 | IFRD1 | IFRD1 Entrez, Source | interferon-related developmental regulator 1 | 1285 | 0.086 | 0.0297 | No |
| 10 | PRKAA1 | PRKAA1 Entrez, Source | protein kinase, AMP-activated, alpha 1 catalytic subunit | 1569 | 0.078 | 0.0171 | No |
| 11 | DNAJB9 | DNAJB9 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 9 | 1749 | 0.073 | 0.0120 | No |
| 12 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 1803 | 0.072 | 0.0162 | No |
| 13 | UBE2V2 | UBE2V2 Entrez, Source | ubiquitin-conjugating enzyme E2 variant 2 | 1845 | 0.071 | 0.0212 | No |
| 14 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 2046 | 0.067 | 0.0137 | No |
| 15 | PPM1A | PPM1A Entrez, Source | protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | 2267 | 0.063 | 0.0042 | No |
| 16 | PREI3 | PREI3 Entrez, Source | preimplantation protein 3 | 2552 | 0.058 | -0.0107 | No |
| 17 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 2777 | 0.054 | -0.0215 | No |
| 18 | SHOX2 | SHOX2 Entrez, Source | short stature homeobox 2 | 2822 | 0.053 | -0.0188 | No |
| 19 | SIP1 | SIP1 Entrez, Source | survival of motor neuron protein interacting protein 1 | 2894 | 0.052 | -0.0182 | No |
| 20 | TAC1 | TAC1 Entrez, Source | tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) | 2930 | 0.051 | -0.0150 | No |
| 21 | RBM13 | RBM13 Entrez, Source | RNA binding motif protein 13 | 3249 | 0.046 | -0.0337 | No |
| 22 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 3307 | 0.046 | -0.0328 | No |
| 23 | OAS1 | OAS1 Entrez, Source | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 3313 | 0.046 | -0.0280 | No |
| 24 | FGF9 | FGF9 Entrez, Source | fibroblast growth factor 9 (glia-activating factor) | 3315 | 0.046 | -0.0229 | No |
| 25 | CREM | CREM Entrez, Source | cAMP responsive element modulator | 3406 | 0.044 | -0.0246 | No |
| 26 | IREB2 | IREB2 Entrez, Source | iron-responsive element binding protein 2 | 3451 | 0.044 | -0.0230 | No |
| 27 | AK2 | AK2 Entrez, Source | adenylate kinase 2 | 3549 | 0.042 | -0.0255 | No |
| 28 | ARHGAP5 | ARHGAP5 Entrez, Source | Rho GTPase activating protein 5 | 3833 | 0.039 | -0.0425 | No |
| 29 | SMNDC1 | SMNDC1 Entrez, Source | survival motor neuron domain containing 1 | 4014 | 0.036 | -0.0519 | No |
| 30 | BET1 | BET1 Entrez, Source | BET1 homolog (S. cerevisiae) | 4110 | 0.035 | -0.0551 | No |
| 31 | ZRF1 | ZRF1 Entrez, Source | zuotin related factor 1 | 4254 | 0.033 | -0.0622 | No |
| 32 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 4408 | 0.031 | -0.0702 | No |
| 33 | RAB5A | RAB5A Entrez, Source | RAB5A, member RAS oncogene family | 4533 | 0.030 | -0.0761 | No |
| 34 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 4607 | 0.029 | -0.0784 | No |
| 35 | NR1D2 | NR1D2 Entrez, Source | nuclear receptor subfamily 1, group D, member 2 | 4748 | 0.027 | -0.0859 | No |
| 36 | THUMPD1 | THUMPD1 Entrez, Source | THUMP domain containing 1 | 5017 | 0.024 | -0.1035 | No |
| 37 | DUSP1 | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 5117 | 0.022 | -0.1084 | No |
| 38 | BNIP1 | BNIP1 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 1 | 5150 | 0.022 | -0.1083 | No |
| 39 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 5178 | 0.022 | -0.1079 | No |
| 40 | SP1 | SP1 Entrez, Source | Sp1 transcription factor | 5193 | 0.022 | -0.1065 | No |
| 41 | EIF2B5 | EIF2B5 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa | 5244 | 0.021 | -0.1079 | No |
| 42 | ZFHX1B | ZFHX1B Entrez, Source | zinc finger homeobox 1b | 5318 | 0.020 | -0.1111 | No |
| 43 | PITPNB | PITPNB Entrez, Source | phosphatidylinositol transfer protein, beta | 5729 | 0.016 | -0.1403 | No |
| 44 | EIF4E | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 5790 | 0.015 | -0.1431 | No |
| 45 | CETN3 | CETN3 Entrez, Source | centrin, EF-hand protein, 3 (CDC31 homolog, yeast) | 5986 | 0.013 | -0.1564 | No |
| 46 | NUP98 | NUP98 Entrez, Source | nucleoporin 98kDa | 6428 | 0.008 | -0.1888 | No |
| 47 | HTATIP | HTATIP Entrez, Source | HIV-1 Tat interacting protein, 60kDa | 6539 | 0.007 | -0.1963 | No |
| 48 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 6706 | 0.005 | -0.2083 | No |
| 49 | DNAJB6 | DNAJB6 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 6 | 6710 | 0.005 | -0.2079 | No |
| 50 | NR4A2 | NR4A2 Entrez, Source | nuclear receptor subfamily 4, group A, member 2 | 6791 | 0.004 | -0.2134 | No |
| 51 | STK17B | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 6841 | 0.004 | -0.2167 | No |
| 52 | CLK3 | CLK3 Entrez, Source | CDC-like kinase 3 | 6845 | 0.004 | -0.2165 | No |
| 53 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 6964 | 0.002 | -0.2252 | No |
| 54 | CLK1 | CLK1 Entrez, Source | CDC-like kinase 1 | 7055 | 0.001 | -0.2318 | No |
| 55 | YTHDC1 | YTHDC1 Entrez, Source | YTH domain containing 1 | 7152 | 0.000 | -0.2391 | No |
| 56 | RNMT | RNMT Entrez, Source | RNA (guanine-7-) methyltransferase | 7197 | -0.000 | -0.2424 | No |
| 57 | TADA2L | TADA2L Entrez, Source | transcriptional adaptor 2 (ADA2 homolog, yeast)-like | 7227 | -0.001 | -0.2445 | No |
| 58 | PIR | PIR Entrez, Source | pirin (iron-binding nuclear protein) | 7426 | -0.003 | -0.2591 | No |
| 59 | KLF6 | KLF6 Entrez, Source | Kruppel-like factor 6 | 7545 | -0.004 | -0.2676 | No |
| 60 | EGR3 | EGR3 Entrez, Source | early growth response 3 | 7547 | -0.004 | -0.2671 | No |
| 61 | MKLN1 | MKLN1 Entrez, Source | muskelin 1, intracellular mediator containing kelch motifs | 7647 | -0.005 | -0.2740 | No |
| 62 | COPS2 | COPS2 Entrez, Source | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 7649 | -0.005 | -0.2735 | No |
| 63 | PRPF4B | PRPF4B Entrez, Source | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | 7657 | -0.005 | -0.2734 | No |
| 64 | NUPL1 | NUPL1 Entrez, Source | nucleoporin like 1 | 7785 | -0.007 | -0.2822 | No |
| 65 | SNRK | SNRK Entrez, Source | SNF related kinase | 7964 | -0.009 | -0.2947 | No |
| 66 | GULP1 | GULP1 Entrez, Source | GULP, engulfment adaptor PTB domain containing 1 | 8014 | -0.010 | -0.2973 | No |
| 67 | FUS | FUS Entrez, Source | fusion (involved in t(12;16) in malignant liposarcoma) | 8068 | -0.010 | -0.3001 | No |
| 68 | BCL10 | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 8361 | -0.014 | -0.3206 | No |
| 69 | UBE1C | UBE1C Entrez, Source | ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) | 8552 | -0.016 | -0.3331 | No |
| 70 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 8567 | -0.016 | -0.3323 | No |
| 71 | PDE4D | PDE4D Entrez, Source | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | 8922 | -0.021 | -0.3567 | No |
| 72 | ARPP-19 | ARPP-19 Entrez, Source | - | 8985 | -0.022 | -0.3589 | No |
| 73 | GNAQ | GNAQ Entrez, Source | guanine nucleotide binding protein (G protein), q polypeptide | 9017 | -0.022 | -0.3588 | No |
| 74 | BST2 | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 9025 | -0.022 | -0.3568 | No |
| 75 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 9067 | -0.023 | -0.3573 | No |
| 76 | MX2 | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 9715 | -0.032 | -0.4025 | No |
| 77 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 9751 | -0.033 | -0.4014 | No |
| 78 | PGAM1 | PGAM1 Entrez, Source | phosphoglycerate mutase 1 (brain) | 9850 | -0.034 | -0.4049 | No |
| 79 | RAB21 | RAB21 Entrez, Source | RAB21, member RAS oncogene family | 10253 | -0.041 | -0.4307 | No |
| 80 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 10315 | -0.042 | -0.4305 | No |
| 81 | IFITM3 | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 10326 | -0.042 | -0.4265 | No |
| 82 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10388 | -0.043 | -0.4262 | No |
| 83 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 10643 | -0.048 | -0.4399 | No |
| 84 | CAPZA2 | CAPZA2 Entrez, Source | capping protein (actin filament) muscle Z-line, alpha 2 | 10967 | -0.055 | -0.4581 | Yes |
| 85 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 10979 | -0.055 | -0.4526 | Yes |
| 86 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 11093 | -0.058 | -0.4545 | Yes |
| 87 | BTG3 | BTG3 Entrez, Source | BTG family, member 3 | 11098 | -0.058 | -0.4482 | Yes |
| 88 | STRN3 | STRN3 Entrez, Source | striatin, calmodulin binding protein 3 | 11105 | -0.058 | -0.4420 | Yes |
| 89 | TDRD7 | TDRD7 Entrez, Source | tudor domain containing 7 | 11201 | -0.060 | -0.4423 | Yes |
| 90 | OGFR | OGFR Entrez, Source | opioid growth factor receptor | 11306 | -0.063 | -0.4431 | Yes |
| 91 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 11527 | -0.069 | -0.4518 | Yes |
| 92 | ZNF292 | ZNF292 Entrez, Source | zinc finger protein 292 | 11534 | -0.070 | -0.4443 | Yes |
| 93 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 11584 | -0.071 | -0.4398 | Yes |
| 94 | FGF2 | FGF2 Entrez, Source | fibroblast growth factor 2 (basic) | 11687 | -0.075 | -0.4390 | Yes |
| 95 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 11892 | -0.083 | -0.4450 | Yes |
| 96 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 12003 | -0.087 | -0.4434 | Yes |
| 97 | PAWR | PAWR Entrez, Source | PRKC, apoptosis, WT1, regulator | 12073 | -0.090 | -0.4383 | Yes |
| 98 | PCTK2 | PCTK2 Entrez, Source | PCTAIRE protein kinase 2 | 12079 | -0.091 | -0.4283 | Yes |
| 99 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12153 | -0.094 | -0.4230 | Yes |
| 100 | DSCR1 | DSCR1 Entrez, Source | Down syndrome critical region gene 1 | 12190 | -0.096 | -0.4148 | Yes |
| 101 | TIMM17A | TIMM17A Entrez, Source | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 12312 | -0.104 | -0.4120 | Yes |
| 102 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 12347 | -0.107 | -0.4024 | Yes |
| 103 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 12557 | -0.122 | -0.4043 | Yes |
| 104 | STX3 | STX3 Entrez, Source | syntaxin 3 | 12578 | -0.124 | -0.3916 | Yes |
| 105 | PSMB9 | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 12661 | -0.131 | -0.3829 | Yes |
| 106 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 12691 | -0.134 | -0.3698 | Yes |
| 107 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 12774 | -0.145 | -0.3595 | Yes |
| 108 | PLSCR1 | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 12879 | -0.161 | -0.3490 | Yes |
| 109 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12915 | -0.168 | -0.3324 | Yes |
| 110 | ABI2 | ABI2 Entrez, Source | abl interactor 2 | 13075 | -0.221 | -0.3192 | Yes |
| 111 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 13105 | -0.234 | -0.2947 | Yes |
| 112 | RRAS2 | RRAS2 Entrez, Source | related RAS viral (r-ras) oncogene homolog 2 | 13125 | -0.244 | -0.2683 | Yes |
| 113 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13239 | -0.335 | -0.2386 | Yes |
| 114 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 13254 | -0.355 | -0.1991 | Yes |
| 115 | ADM | ADM Entrez, Source | adrenomedullin | 13274 | -0.393 | -0.1556 | Yes |
| 116 | FHL2 | FHL2 Entrez, Source | four and a half LIM domains 2 | 13281 | -0.405 | -0.1098 | Yes |
| 117 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13312 | -0.498 | -0.0552 | Yes |
| 118 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 13313 | -0.503 | 0.0022 | Yes |
