Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | SANA_TNFA_ENDOTHELIAL_DN |
| Enrichment Score (ES) | -0.55602 |
| Normalized Enrichment Score (NES) | -1.8327706 |
| Nominal p-value | 0.0016750419 |
| FDR q-value | 0.035324078 |
| FWER p-Value | 0.912 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ACE | ACE Entrez, Source | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 281 | 0.152 | 0.0084 | No |
| 2 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 406 | 0.135 | 0.0252 | No |
| 3 | EMCN | EMCN Entrez, Source | endomucin | 874 | 0.104 | 0.0103 | No |
| 4 | DNAH11 | DNAH11 Entrez, Source | dynein, axonemal, heavy chain 11 | 923 | 0.101 | 0.0263 | No |
| 5 | ARL5A | ARL5A Entrez, Source | ADP-ribosylation factor-like 5A | 1239 | 0.088 | 0.0197 | No |
| 6 | CRIP2 | CRIP2 Entrez, Source | cysteine-rich protein 2 | 1464 | 0.080 | 0.0185 | No |
| 7 | ALDH1A1 | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 1653 | 0.076 | 0.0191 | No |
| 8 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 1971 | 0.069 | 0.0086 | No |
| 9 | CALCRL | CALCRL Entrez, Source | calcitonin receptor-like | 1986 | 0.069 | 0.0209 | No |
| 10 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 2016 | 0.068 | 0.0319 | No |
| 11 | KDR | KDR Entrez, Source | kinase insert domain receptor (a type III receptor tyrosine kinase) | 2505 | 0.058 | 0.0065 | No |
| 12 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 2672 | 0.056 | 0.0048 | No |
| 13 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 2780 | 0.054 | 0.0072 | No |
| 14 | PHLDA1 | PHLDA1 Entrez, Source | pleckstrin homology-like domain, family A, member 1 | 2920 | 0.051 | 0.0067 | No |
| 15 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 3166 | 0.048 | -0.0024 | No |
| 16 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 3630 | 0.041 | -0.0292 | No |
| 17 | PRKCH | PRKCH Entrez, Source | protein kinase C, eta | 3971 | 0.037 | -0.0476 | No |
| 18 | JAG2 | JAG2 Entrez, Source | jagged 2 | 4098 | 0.035 | -0.0503 | No |
| 19 | APLN | APLN Entrez, Source | apelin, AGTRL1 ligand | 4276 | 0.033 | -0.0572 | No |
| 20 | PALMD | PALMD Entrez, Source | palmdelphin | 4443 | 0.031 | -0.0638 | No |
| 21 | ATP5A1 | ATP5A1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 5149 | 0.022 | -0.1125 | No |
| 22 | VWF | VWF Entrez, Source | von Willebrand factor | 5296 | 0.020 | -0.1196 | No |
| 23 | SFRS7 | SFRS7 Entrez, Source | splicing factor, arginine/serine-rich 7, 35kDa | 5474 | 0.019 | -0.1293 | No |
| 24 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 6019 | 0.013 | -0.1678 | No |
| 25 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 6080 | 0.012 | -0.1699 | No |
| 26 | RPS3A | RPS3A Entrez, Source | ribosomal protein S3A | 6170 | 0.011 | -0.1744 | No |
| 27 | TPT1 | TPT1 Entrez, Source | tumor protein, translationally-controlled 1 | 6276 | 0.010 | -0.1804 | No |
| 28 | SDPR | SDPR Entrez, Source | serum deprivation response (phosphatidylserine binding protein) | 6834 | 0.004 | -0.2216 | No |
| 29 | BGN | BGN Entrez, Source | biglycan | 7068 | 0.001 | -0.2389 | No |
| 30 | PCTP | PCTP Entrez, Source | phosphatidylcholine transfer protein | 7897 | -0.008 | -0.2996 | No |
| 31 | ARL6IP1 | ARL6IP1 Entrez, Source | ADP-ribosylation factor-like 6 interacting protein 1 | 7958 | -0.009 | -0.3023 | No |
| 32 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 7988 | -0.009 | -0.3027 | No |
| 33 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 8020 | -0.010 | -0.3032 | No |
| 34 | NT5E | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 8154 | -0.011 | -0.3110 | No |
| 35 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 8238 | -0.012 | -0.3149 | No |
| 36 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 8726 | -0.018 | -0.3480 | No |
| 37 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 9039 | -0.022 | -0.3671 | No |
| 38 | PGAM2 | PGAM2 Entrez, Source | phosphoglycerate mutase 2 (muscle) | 9063 | -0.023 | -0.3644 | No |
| 39 | ATP1B3 | ATP1B3 Entrez, Source | ATPase, Na+/K+ transporting, beta 3 polypeptide | 9618 | -0.031 | -0.4001 | No |
| 40 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 9887 | -0.035 | -0.4135 | No |
| 41 | HTR1B | HTR1B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 1B | 10922 | -0.054 | -0.4808 | No |
| 42 | SMYD2 | SMYD2 Entrez, Source | SET and MYND domain containing 2 | 11041 | -0.057 | -0.4787 | No |
| 43 | NFIB | NFIB Entrez, Source | nuclear factor I/B | 11596 | -0.072 | -0.5065 | No |
| 44 | CLU | CLU Entrez, Source | clusterin | 11686 | -0.075 | -0.4986 | No |
| 45 | CAPNS1 | CAPNS1 Entrez, Source | calpain, small subunit 1 | 12082 | -0.091 | -0.5106 | No |
| 46 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 12686 | -0.133 | -0.5301 | Yes |
| 47 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12716 | -0.137 | -0.5057 | Yes |
| 48 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 12783 | -0.145 | -0.4824 | Yes |
| 49 | TMSB4X | TMSB4X Entrez, Source | thymosin, beta 4, X-linked | 13134 | -0.249 | -0.4604 | Yes |
| 50 | DNAJB4 | DNAJB4 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 4 | 13193 | -0.289 | -0.4085 | Yes |
| 51 | DDR1 | DDR1 Entrez, Source | discoidin domain receptor family, member 1 | 13240 | -0.338 | -0.3462 | Yes |
| 52 | FHL2 | FHL2 Entrez, Source | four and a half LIM domains 2 | 13281 | -0.405 | -0.2705 | Yes |
| 53 | PEA15 | PEA15 Entrez, Source | phosphoprotein enriched in astrocytes 15 | 13282 | -0.412 | -0.1903 | Yes |
| 54 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13312 | -0.498 | -0.0956 | Yes |
| 55 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 13313 | -0.503 | 0.0022 | Yes |
