Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | SERUM_FIBROBLAST_CORE_UP |
| Enrichment Score (ES) | -0.552686 |
| Normalized Enrichment Score (NES) | -2.0353765 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.005784527 |
| FWER p-Value | 0.131 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GNG11 | GNG11 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 11 | 35 | 0.306 | 0.0332 | No |
| 2 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 151 | 0.192 | 0.0471 | No |
| 3 | PTS | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 877 | 0.104 | 0.0044 | No |
| 4 | DHFR | DHFR Entrez, Source | dihydrofolate reductase | 883 | 0.103 | 0.0162 | No |
| 5 | MTHFD1 | MTHFD1 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 1392 | 0.083 | -0.0125 | No |
| 6 | FARSLB | FARSLB Entrez, Source | phenylalanine-tRNA synthetase-like, beta subunit | 1877 | 0.070 | -0.0408 | No |
| 7 | HAS2 | HAS2 Entrez, Source | hyaluronan synthase 2 | 2122 | 0.065 | -0.0515 | No |
| 8 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 2361 | 0.061 | -0.0624 | No |
| 9 | NUP107 | NUP107 Entrez, Source | nucleoporin 107kDa | 2504 | 0.058 | -0.0662 | No |
| 10 | GPLD1 | GPLD1 Entrez, Source | glycosylphosphatidylinositol specific phospholipase D1 | 2945 | 0.051 | -0.0935 | No |
| 11 | HMGN2 | HMGN2 Entrez, Source | high-mobility group nucleosomal binding domain 2 | 3017 | 0.050 | -0.0930 | No |
| 12 | SAR1B | SAR1B Entrez, Source | SAR1 gene homolog B (S. cerevisiae) | 3157 | 0.048 | -0.0979 | No |
| 13 | EBNA1BP2 | EBNA1BP2 Entrez, Source | EBNA1 binding protein 2 | 3279 | 0.046 | -0.1017 | No |
| 14 | RPN1 | RPN1 Entrez, Source | ribophorin I | 3301 | 0.046 | -0.0979 | No |
| 15 | TOMM40 | TOMM40 Entrez, Source | translocase of outer mitochondrial membrane 40 homolog (yeast) | 3471 | 0.043 | -0.1056 | No |
| 16 | HNRPA3 | HNRPA3 Entrez, Source | heterogeneous nuclear ribonucleoprotein A3 | 3502 | 0.043 | -0.1028 | No |
| 17 | SSR3 | SSR3 Entrez, Source | signal sequence receptor, gamma (translocon-associated protein gamma) | 3557 | 0.042 | -0.1019 | No |
| 18 | SNRPA | SNRPA Entrez, Source | small nuclear ribonucleoprotein polypeptide A | 3596 | 0.042 | -0.0999 | No |
| 19 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 3670 | 0.041 | -0.1006 | No |
| 20 | SLC25A5 | SLC25A5 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 3958 | 0.037 | -0.1180 | No |
| 21 | UMPS | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 4001 | 0.036 | -0.1169 | No |
| 22 | DCLRE1B | DCLRE1B Entrez, Source | DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) | 4187 | 0.034 | -0.1269 | No |
| 23 | TDP1 | TDP1 Entrez, Source | tyrosyl-DNA phosphodiesterase 1 | 4633 | 0.028 | -0.1572 | No |
| 24 | MRPL12 | MRPL12 Entrez, Source | mitochondrial ribosomal protein L12 | 4897 | 0.025 | -0.1741 | No |
| 25 | MCTS1 | MCTS1 Entrez, Source | malignant T cell amplified sequence 1 | 5122 | 0.022 | -0.1884 | No |
| 26 | CEP78 | CEP78 Entrez, Source | centrosomal protein 78kDa | 5157 | 0.022 | -0.1884 | No |
| 27 | HNRPAB | HNRPAB Entrez, Source | heterogeneous nuclear ribonucleoprotein A/B | 5269 | 0.021 | -0.1944 | No |
| 28 | POLE3 | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 5404 | 0.019 | -0.2022 | No |
| 29 | NUP35 | NUP35 Entrez, Source | nucleoporin 35kDa | 5423 | 0.019 | -0.2014 | No |
| 30 | NCLN | NCLN Entrez, Source | nicalin homolog (zebrafish) | 5480 | 0.019 | -0.2034 | No |
| 31 | LYAR | LYAR Entrez, Source | - | 5575 | 0.017 | -0.2085 | No |
| 32 | PCSK7 | PCSK7 Entrez, Source | proprotein convertase subtilisin/kexin type 7 | 5635 | 0.017 | -0.2110 | No |
| 33 | EIF4G1 | EIF4G1 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 1 | 5763 | 0.015 | -0.2188 | No |
| 34 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 6219 | 0.011 | -0.2519 | No |
| 35 | MKKS | MKKS Entrez, Source | McKusick-Kaufman syndrome | 6268 | 0.010 | -0.2543 | No |
| 36 | MRPL37 | MRPL37 Entrez, Source | mitochondrial ribosomal protein L37 | 6494 | 0.008 | -0.2704 | No |
| 37 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 6558 | 0.007 | -0.2744 | No |
| 38 | EMP2 | EMP2 Entrez, Source | epithelial membrane protein 2 | 6612 | 0.006 | -0.2776 | No |
| 39 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 6799 | 0.004 | -0.2912 | No |
| 40 | RNF138 | RNF138 Entrez, Source | ring finger protein 138 | 6850 | 0.004 | -0.2945 | No |
| 41 | NUP93 | NUP93 Entrez, Source | nucleoporin 93kDa | 6978 | 0.002 | -0.3039 | No |
| 42 | CDCA4 | CDCA4 Entrez, Source | cell division cycle associated 4 | 7119 | 0.001 | -0.3144 | No |
| 43 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 7469 | -0.003 | -0.3403 | No |
| 44 | SFRS10 | SFRS10 Entrez, Source | splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) | 7569 | -0.005 | -0.3473 | No |
| 45 | CCT5 | CCT5 Entrez, Source | chaperonin containing TCP1, subunit 5 (epsilon) | 7574 | -0.005 | -0.3471 | No |
| 46 | PSMD12 | PSMD12 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 7695 | -0.006 | -0.3554 | No |
| 47 | NUPL1 | NUPL1 Entrez, Source | nucleoporin like 1 | 7785 | -0.007 | -0.3614 | No |
| 48 | WDR77 | WDR77 Entrez, Source | WD repeat domain 77 | 8016 | -0.010 | -0.3776 | No |
| 49 | COPB2 | COPB2 Entrez, Source | coatomer protein complex, subunit beta 2 (beta prime) | 8095 | -0.011 | -0.3822 | No |
| 50 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 8105 | -0.011 | -0.3817 | No |
| 51 | TXNL2 | TXNL2 Entrez, Source | thioredoxin-like 2 | 8255 | -0.012 | -0.3915 | No |
| 52 | CENPJ | CENPJ Entrez, Source | centromere protein J | 8301 | -0.013 | -0.3933 | No |
| 53 | EIF4EBP1 | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 8352 | -0.014 | -0.3955 | No |
| 54 | SFRS2 | SFRS2 Entrez, Source | splicing factor, arginine/serine-rich 2 | 8369 | -0.014 | -0.3951 | No |
| 55 | PSMD2 | PSMD2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 8388 | -0.014 | -0.3948 | No |
| 56 | SNRPB | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 9192 | -0.024 | -0.4526 | No |
| 57 | ST3GAL6 | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 9231 | -0.025 | -0.4526 | No |
| 58 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 9384 | -0.027 | -0.4609 | No |
| 59 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 9706 | -0.032 | -0.4813 | No |
| 60 | PSMA7 | PSMA7 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 9797 | -0.033 | -0.4842 | No |
| 61 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 9823 | -0.034 | -0.4822 | No |
| 62 | DUT | DUT Entrez, Source | dUTP pyrophosphatase | 9896 | -0.035 | -0.4835 | No |
| 63 | LYPLA2 | LYPLA2 Entrez, Source | lysophospholipase II | 9951 | -0.036 | -0.4834 | No |
| 64 | RPP40 | RPP40 Entrez, Source | ribonuclease P 40kDa subunit | 10015 | -0.037 | -0.4838 | No |
| 65 | PSMC3 | PSMC3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 10034 | -0.037 | -0.4808 | No |
| 66 | ACTL6A | ACTL6A Entrez, Source | actin-like 6A | 10097 | -0.038 | -0.4810 | No |
| 67 | TPRKB | TPRKB Entrez, Source | TP53RK binding protein | 10275 | -0.041 | -0.4896 | No |
| 68 | PFN1 | PFN1 Entrez, Source | profilin 1 | 10319 | -0.042 | -0.4879 | No |
| 69 | DCK | DCK Entrez, Source | deoxycytidine kinase | 10358 | -0.043 | -0.4858 | No |
| 70 | EPHB1 | EPHB1 Entrez, Source | EPH receptor B1 | 10916 | -0.054 | -0.5215 | No |
| 71 | MNAT1 | MNAT1 Entrez, Source | menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) | 11046 | -0.057 | -0.5246 | No |
| 72 | FABP5 | FABP5 Entrez, Source | fatty acid binding protein 5 (psoriasis-associated) | 11296 | -0.062 | -0.5361 | No |
| 73 | NLN | NLN Entrez, Source | neurolysin (metallopeptidase M3 family) | 11516 | -0.069 | -0.5446 | Yes |
| 74 | HNRPR | HNRPR Entrez, Source | heterogeneous nuclear ribonucleoprotein R | 11604 | -0.072 | -0.5427 | Yes |
| 75 | SDC1 | SDC1 Entrez, Source | syndecan 1 | 11699 | -0.075 | -0.5410 | Yes |
| 76 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 11760 | -0.077 | -0.5365 | Yes |
| 77 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 11780 | -0.078 | -0.5288 | Yes |
| 78 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 11845 | -0.081 | -0.5241 | Yes |
| 79 | RNF41 | RNF41 Entrez, Source | ring finger protein 41 | 11978 | -0.086 | -0.5240 | Yes |
| 80 | NPTN | NPTN Entrez, Source | neuroplastin | 12006 | -0.087 | -0.5158 | Yes |
| 81 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 12106 | -0.092 | -0.5125 | Yes |
| 82 | RNASEH2A | RNASEH2A Entrez, Source | ribonuclease H2, subunit A | 12160 | -0.095 | -0.5055 | Yes |
| 83 | GGH | GGH Entrez, Source | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 12243 | -0.099 | -0.5000 | Yes |
| 84 | TNFRSF12A | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 12397 | -0.111 | -0.4986 | Yes |
| 85 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 12427 | -0.112 | -0.4876 | Yes |
| 86 | DCBLD2 | DCBLD2 Entrez, Source | discoidin, CUB and LCCL domain containing 2 | 12485 | -0.117 | -0.4783 | Yes |
| 87 | WSB2 | WSB2 Entrez, Source | WD repeat and SOCS box-containing 2 | 12515 | -0.118 | -0.4666 | Yes |
| 88 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 12561 | -0.122 | -0.4557 | Yes |
| 89 | STX3 | STX3 Entrez, Source | syntaxin 3 | 12578 | -0.124 | -0.4424 | Yes |
| 90 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12631 | -0.128 | -0.4313 | Yes |
| 91 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12716 | -0.137 | -0.4216 | Yes |
| 92 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 12734 | -0.139 | -0.4066 | Yes |
| 93 | ACTC1 | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 12741 | -0.140 | -0.3906 | Yes |
| 94 | CCDC5 | CCDC5 Entrez, Source | coiled-coil domain containing 5 (spindle associated) | 12838 | -0.154 | -0.3798 | Yes |
| 95 | CLCF1 | CLCF1 Entrez, Source | cardiotrophin-like cytokine factor 1 | 12884 | -0.162 | -0.3642 | Yes |
| 96 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12915 | -0.168 | -0.3468 | Yes |
| 97 | NUDT1 | NUDT1 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 12918 | -0.169 | -0.3271 | Yes |
| 98 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13025 | -0.196 | -0.3121 | Yes |
| 99 | SMS | SMS Entrez, Source | spermine synthase | 13073 | -0.219 | -0.2899 | Yes |
| 100 | ID3 | ID3 Entrez, Source | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 13220 | -0.314 | -0.2641 | Yes |
| 101 | PDLIM7 | PDLIM7 Entrez, Source | PDZ and LIM domain 7 (enigma) | 13231 | -0.327 | -0.2265 | Yes |
| 102 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13242 | -0.345 | -0.1868 | Yes |
| 103 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13315 | -0.511 | -0.1323 | Yes |
| 104 | PFKP | PFKP Entrez, Source | phosphofructokinase, platelet | 13318 | -0.516 | -0.0720 | Yes |
| 105 | MSN | MSN Entrez, Source | moesin | 13327 | -0.629 | 0.0011 | Yes |
