Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | SHEPARD_CRASH_AND_BURN_MUT_VS_WT_UP |
| Enrichment Score (ES) | 0.36623168 |
| Normalized Enrichment Score (NES) | 1.4401805 |
| Nominal p-value | 0.034188036 |
| FDR q-value | 0.18370575 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOS | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 0 | 1.012 | 0.1490 | Yes |
| 2 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 56 | 0.277 | 0.1856 | Yes |
| 3 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 329 | 0.145 | 0.1865 | Yes |
| 4 | RBP4 | RBP4 Entrez, Source | retinol binding protein 4, plasma | 409 | 0.134 | 0.2003 | Yes |
| 5 | IGFBP1 | IGFBP1 Entrez, Source | insulin-like growth factor binding protein 1 | 459 | 0.129 | 0.2156 | Yes |
| 6 | PLK3 | PLK3 Entrez, Source | polo-like kinase 3 (Drosophila) | 527 | 0.123 | 0.2287 | Yes |
| 7 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 546 | 0.122 | 0.2453 | Yes |
| 8 | GPD1 | GPD1 Entrez, Source | glycerol-3-phosphate dehydrogenase 1 (soluble) | 555 | 0.121 | 0.2625 | Yes |
| 9 | AKR7A2 | AKR7A2 Entrez, Source | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 712 | 0.111 | 0.2671 | Yes |
| 10 | CEBPB | CEBPB Entrez, Source | CCAAT/enhancer binding protein (C/EBP), beta | 732 | 0.110 | 0.2819 | Yes |
| 11 | C6 | C6 Entrez, Source | complement component 6 | 786 | 0.107 | 0.2937 | Yes |
| 12 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 825 | 0.106 | 0.3064 | Yes |
| 13 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 886 | 0.103 | 0.3171 | Yes |
| 14 | SSR1 | SSR1 Entrez, Source | signal sequence receptor, alpha (translocon-associated protein alpha) | 1133 | 0.092 | 0.3121 | Yes |
| 15 | WDR12 | WDR12 Entrez, Source | WD repeat domain 12 | 1134 | 0.092 | 0.3256 | Yes |
| 16 | DUSP4 | DUSP4 Entrez, Source | dual specificity phosphatase 4 | 1225 | 0.089 | 0.3319 | Yes |
| 17 | BOP1 | BOP1 Entrez, Source | block of proliferation 1 | 1230 | 0.089 | 0.3446 | Yes |
| 18 | PIM1 | PIM1 Entrez, Source | pim-1 oncogene | 1264 | 0.087 | 0.3549 | Yes |
| 19 | CTH | CTH Entrez, Source | cystathionase (cystathionine gamma-lyase) | 1284 | 0.086 | 0.3662 | Yes |
| 20 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 1586 | 0.077 | 0.3549 | No |
| 21 | DNAJA3 | DNAJA3 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 3 | 1753 | 0.073 | 0.3532 | No |
| 22 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 2033 | 0.067 | 0.3420 | No |
| 23 | TOB1 | TOB1 Entrez, Source | transducer of ERBB2, 1 | 2158 | 0.065 | 0.3422 | No |
| 24 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 2192 | 0.064 | 0.3492 | No |
| 25 | MYBBP1A | MYBBP1A Entrez, Source | MYB binding protein (P160) 1a | 2193 | 0.064 | 0.3586 | No |
| 26 | CIRH1A | CIRH1A Entrez, Source | cirrhosis, autosomal recessive 1A (cirhin) | 2279 | 0.063 | 0.3614 | No |
| 27 | AK3L1 | AK3L1 Entrez, Source | adenylate kinase 3-like 1 | 2337 | 0.061 | 0.3661 | No |
| 28 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 2777 | 0.054 | 0.3409 | No |
| 29 | IMP4 | IMP4 Entrez, Source | IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) | 2835 | 0.053 | 0.3444 | No |
| 30 | HES1 | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 3122 | 0.048 | 0.3299 | No |
| 31 | SLC16A6 | SLC16A6 Entrez, Source | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | 3332 | 0.045 | 0.3209 | No |
| 32 | ETF1 | ETF1 Entrez, Source | eukaryotic translation termination factor 1 | 3680 | 0.041 | 0.3007 | No |
| 33 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 3927 | 0.037 | 0.2876 | No |
| 34 | FBL | FBL Entrez, Source | fibrillarin | 4004 | 0.036 | 0.2873 | No |
| 35 | MRPS18B | MRPS18B Entrez, Source | mitochondrial ribosomal protein S18B | 4053 | 0.036 | 0.2889 | No |
| 36 | FTSJ3 | FTSJ3 Entrez, Source | FtsJ homolog 3 (E. coli) | 4361 | 0.032 | 0.2704 | No |
| 37 | PFKFB3 | PFKFB3 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 4397 | 0.031 | 0.2724 | No |
| 38 | SHMT1 | SHMT1 Entrez, Source | serine hydroxymethyltransferase 1 (soluble) | 4738 | 0.027 | 0.2508 | No |
| 39 | CYP26A1 | CYP26A1 Entrez, Source | cytochrome P450, family 26, subfamily A, polypeptide 1 | 4758 | 0.027 | 0.2533 | No |
| 40 | MKNK2 | MKNK2 Entrez, Source | MAP kinase interacting serine/threonine kinase 2 | 4889 | 0.025 | 0.2472 | No |
| 41 | MRPL12 | MRPL12 Entrez, Source | mitochondrial ribosomal protein L12 | 4897 | 0.025 | 0.2504 | No |
| 42 | NOG | NOG Entrez, Source | noggin | 4913 | 0.025 | 0.2529 | No |
| 43 | PPAN | PPAN Entrez, Source | peter pan homolog (Drosophila) | 5016 | 0.024 | 0.2487 | No |
| 44 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 5075 | 0.023 | 0.2477 | No |
| 45 | SLC12A3 | SLC12A3 Entrez, Source | solute carrier family 12 (sodium/chloride transporters), member 3 | 5641 | 0.017 | 0.2075 | No |
| 46 | EIF4E | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 5790 | 0.015 | 0.1986 | No |
| 47 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 6296 | 0.010 | 0.1619 | No |
| 48 | ATPIF1 | ATPIF1 Entrez, Source | ATPase inhibitory factor 1 | 6365 | 0.009 | 0.1581 | No |
| 49 | FN1 | FN1 Entrez, Source | fibronectin 1 | 7215 | -0.000 | 0.0941 | No |
| 50 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 7252 | -0.001 | 0.0916 | No |
| 51 | ODC1 | ODC1 Entrez, Source | ornithine decarboxylase 1 | 7596 | -0.005 | 0.0664 | No |
| 52 | TOMM20 | TOMM20 Entrez, Source | translocase of outer mitochondrial membrane 20 homolog (yeast) | 7655 | -0.005 | 0.0628 | No |
| 53 | CORT | CORT Entrez, Source | cortistatin | 7765 | -0.007 | 0.0556 | No |
| 54 | SRPRB | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 7795 | -0.007 | 0.0544 | No |
| 55 | IGF2 | IGF2 Entrez, Source | insulin-like growth factor 2 (somatomedin A) | 8017 | -0.010 | 0.0392 | No |
| 56 | JUN | JUN Entrez, Source | jun oncogene | 8081 | -0.010 | 0.0360 | No |
| 57 | POP4 | POP4 Entrez, Source | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) | 8189 | -0.012 | 0.0296 | No |
| 58 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 8238 | -0.012 | 0.0278 | No |
| 59 | DUSP5 | DUSP5 Entrez, Source | dual specificity phosphatase 5 | 8419 | -0.014 | 0.0163 | No |
| 60 | RGC32 | RGC32 Entrez, Source | - | 8939 | -0.021 | -0.0197 | No |
| 61 | TAF9 | TAF9 Entrez, Source | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa | 9217 | -0.025 | -0.0370 | No |
| 62 | PPP1R14A | PPP1R14A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 14A | 9344 | -0.027 | -0.0425 | No |
| 63 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 9384 | -0.027 | -0.0415 | No |
| 64 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.0542 | No |
| 65 | ITGB4BP | ITGB4BP Entrez, Source | integrin beta 4 binding protein | 9616 | -0.031 | -0.0498 | No |
| 66 | AP3M1 | AP3M1 Entrez, Source | adaptor-related protein complex 3, mu 1 subunit | 9671 | -0.032 | -0.0492 | No |
| 67 | MYOG | MYOG Entrez, Source | myogenin (myogenic factor 4) | 10152 | -0.039 | -0.0796 | No |
| 68 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 10280 | -0.041 | -0.0832 | No |
| 69 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10281 | -0.041 | -0.0771 | No |
| 70 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 10614 | -0.047 | -0.0952 | No |
| 71 | ADAM10 | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 11154 | -0.059 | -0.1271 | No |
| 72 | MRPS18A | MRPS18A Entrez, Source | mitochondrial ribosomal protein S18A | 11364 | -0.064 | -0.1334 | No |
| 73 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 11387 | -0.065 | -0.1256 | No |
| 74 | SLC12A7 | SLC12A7 Entrez, Source | solute carrier family 12 (potassium/chloride transporters), member 7 | 11942 | -0.085 | -0.1549 | No |
| 75 | DSCR1 | DSCR1 Entrez, Source | Down syndrome critical region gene 1 | 12190 | -0.096 | -0.1593 | No |
| 76 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 12473 | -0.116 | -0.1635 | No |
| 77 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 12557 | -0.122 | -0.1518 | No |
| 78 | RASL11B | RASL11B Entrez, Source | RAS-like, family 11, member B | 12573 | -0.123 | -0.1349 | No |
| 79 | BMP2 | BMP2 Entrez, Source | bone morphogenetic protein 2 | 12648 | -0.130 | -0.1213 | No |
| 80 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 12969 | -0.181 | -0.1189 | No |
| 81 | HSPA4 | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 13162 | -0.265 | -0.0943 | No |
| 82 | FST | FST Entrez, Source | follistatin | 13176 | -0.277 | -0.0544 | No |
| 83 | SERPINH1 | SERPINH1 Entrez, Source | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 13296 | -0.454 | 0.0035 | No |
