Details for gene set SUBSTRATE_SPECIFIC_CHANNEL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos
Phenotype	class.cls#double_gel_48h_versus_single_gel_48h_repos
Upregulated in class	double_gel_48h
GeneSet	SUBSTRATE_SPECIFIC_CHANNEL_ACTIVITY
Enrichment Score (ES)	0.45168808
Normalized Enrichment Score (NES)	1.9402857
Nominal p-value	0.0
FDR q-value	0.011344977
FWER p-Value	0.4

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	AQP9	AQP9 Entrez, Source	aquaporin 9	57	0.272	0.0421	Yes
2	KCNA2	KCNA2 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 2	215	0.170	0.0592	Yes
3	NOX1	NOX1 Entrez, Source	NADPH oxidase 1	373	0.139	0.0709	Yes
4	TRPM2	TRPM2 Entrez, Source	transient receptor potential cation channel, subfamily M, member 2	595	0.118	0.0744	Yes
5	CACNG4	CACNG4 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 4	690	0.112	0.0864	Yes
6	CLCN1	CLCN1 Entrez, Source	chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant)	713	0.111	0.1037	Yes
7	AQP8	AQP8 Entrez, Source	aquaporin 8	728	0.110	0.1214	Yes
8	HTR3B	HTR3B Entrez, Source	5-hydroxytryptamine (serotonin) receptor 3B	774	0.108	0.1364	Yes
9	TRPV2	TRPV2 Entrez, Source	transient receptor potential cation channel, subfamily V, member 2	808	0.106	0.1520	Yes
10	KCNN3	KCNN3 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	884	0.103	0.1640	Yes
11	SCN5A	SCN5A Entrez, Source	sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)	980	0.098	0.1736	Yes
12	AQP2	AQP2 Entrez, Source	aquaporin 2 (collecting duct)	1201	0.090	0.1722	Yes
13	KCNJ10	KCNJ10 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 10	1373	0.083	0.1735	Yes
14	CACNB4	CACNB4 Entrez, Source	calcium channel, voltage-dependent, beta 4 subunit	1403	0.083	0.1854	Yes
15	KCNQ1	KCNQ1 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 1	1472	0.080	0.1939	Yes
16	PDPN	PDPN Entrez, Source	podoplanin	1510	0.079	0.2046	Yes
17	KCNK15	KCNK15 Entrez, Source	potassium channel, subfamily K, member 15	1594	0.077	0.2115	Yes
18	GLRB	GLRB Entrez, Source	glycine receptor, beta	1617	0.077	0.2229	Yes
19	KCNS1	KCNS1 Entrez, Source	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	1635	0.076	0.2346	Yes
20	TRPV1	TRPV1 Entrez, Source	transient receptor potential cation channel, subfamily V, member 1	1660	0.075	0.2456	Yes
21	TRPC5	TRPC5 Entrez, Source	transient receptor potential cation channel, subfamily C, member 5	1774	0.073	0.2495	Yes
22	BSND	BSND Entrez, Source	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	1812	0.072	0.2589	Yes
23	CACNG5	CACNG5 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 5	1827	0.072	0.2701	Yes
24	CHRNA2	CHRNA2 Entrez, Source	cholinergic receptor, nicotinic, alpha 2 (neuronal)	1828	0.071	0.2823	Yes
25	ACCN4	ACCN4 Entrez, Source	amiloride-sensitive cation channel 4, pituitary	1833	0.071	0.2941	Yes
26	SCN4A	SCN4A Entrez, Source	sodium channel, voltage-gated, type IV, alpha	1871	0.071	0.3034	Yes
27	KCNH2	KCNH2 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 2	1971	0.069	0.3076	Yes
28	AQP6	AQP6 Entrez, Source	aquaporin 6, kidney specific	2012	0.068	0.3161	Yes
29	SCN9A	SCN9A Entrez, Source	sodium channel, voltage-gated, type IX, alpha	2059	0.067	0.3240	Yes
30	CACNB1	CACNB1 Entrez, Source	calcium channel, voltage-dependent, beta 1 subunit	2156	0.065	0.3278	Yes
31	CHRNA1	CHRNA1 Entrez, Source	cholinergic receptor, nicotinic, alpha 1 (muscle)	2179	0.064	0.3371	Yes
32	KCNIP2	KCNIP2 Entrez, Source	Kv channel interacting protein 2	2194	0.064	0.3470	Yes
33	SCNN1G	SCNN1G Entrez, Source	sodium channel, nonvoltage-gated 1, gamma	2288	0.062	0.3506	Yes
34	GLRA1	GLRA1 Entrez, Source	glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)	2320	0.062	0.3587	Yes
35	KCNJ12	KCNJ12 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 12	2409	0.060	0.3623	Yes
36	CACNG2	CACNG2 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 2	2443	0.060	0.3700	Yes
37	KCNJ4	KCNJ4 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 4	2467	0.059	0.3783	Yes
38	SCNN1B	SCNN1B Entrez, Source	sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)	2473	0.059	0.3880	Yes
39	P2RX7	P2RX7 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 7	2611	0.057	0.3873	Yes
40	KCNMB4	KCNMB4 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, beta member 4	2759	0.054	0.3854	Yes
41	KCNH1	KCNH1 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 1	2922	0.051	0.3819	Yes
42	SCN7A	SCN7A Entrez, Source	sodium channel, voltage-gated, type VII, alpha	3006	0.050	0.3841	Yes
43	GLRA2	GLRA2 Entrez, Source	glycine receptor, alpha 2	3025	0.050	0.3913	Yes
44	CHRND	CHRND Entrez, Source	cholinergic receptor, nicotinic, delta	3127	0.048	0.3919	Yes
45	CACNA1S	CACNA1S Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1S subunit	3213	0.047	0.3934	Yes
46	CACNA1C	CACNA1C Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1C subunit	3252	0.046	0.3985	Yes
47	KCNH3	KCNH3 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 3	3309	0.046	0.4020	Yes
48	CACNA1A	CACNA1A Entrez, Source	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	3318	0.046	0.4092	Yes
49	KCNB2	KCNB2 Entrez, Source	potassium voltage-gated channel, Shab-related subfamily, member 2	3321	0.045	0.4168	Yes
50	AQP5	AQP5 Entrez, Source	aquaporin 5	3444	0.044	0.4150	Yes
51	KCNG2	KCNG2 Entrez, Source	potassium voltage-gated channel, subfamily G, member 2	3538	0.042	0.4152	Yes
52	KCNMB1	KCNMB1 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, beta member 1	3598	0.042	0.4179	Yes
53	HTR3A	HTR3A Entrez, Source	5-hydroxytryptamine (serotonin) receptor 3A	3637	0.041	0.4220	Yes
54	KCNJ5	KCNJ5 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 5	3690	0.041	0.4250	Yes
55	NMUR2	NMUR2 Entrez, Source	neuromedin U receptor 2	3861	0.039	0.4187	Yes
56	TRPV6	TRPV6 Entrez, Source	transient receptor potential cation channel, subfamily V, member 6	3865	0.038	0.4251	Yes
57	CUL5	CUL5 Entrez, Source	cullin 5	3868	0.038	0.4315	Yes
58	KCNQ3	KCNQ3 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 3	3973	0.037	0.4299	Yes
59	CHRNA3	CHRNA3 Entrez, Source	cholinergic receptor, nicotinic, alpha 3	4005	0.036	0.4337	Yes
60	KCNS3	KCNS3 Entrez, Source	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	4055	0.036	0.4361	Yes
61	CACNA1B	CACNA1B Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1B subunit	4117	0.035	0.4374	Yes
62	CACNB3	CACNB3 Entrez, Source	calcium channel, voltage-dependent, beta 3 subunit	4260	0.033	0.4323	Yes
63	KCNJ15	KCNJ15 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 15	4296	0.033	0.4352	Yes
64	CACNA1D	CACNA1D Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1D subunit	4301	0.033	0.4404	Yes
65	KCNA6	KCNA6 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 6	4340	0.032	0.4430	Yes
66	KCNA5	KCNA5 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 5	4364	0.032	0.4467	Yes
67	TRPV5	TRPV5 Entrez, Source	transient receptor potential cation channel, subfamily V, member 5	4500	0.030	0.4416	Yes
68	ACCN1	ACCN1 Entrez, Source	amiloride-sensitive cation channel 1, neuronal (degenerin)	4520	0.030	0.4453	Yes
69	AQP7	AQP7 Entrez, Source	aquaporin 7	4534	0.030	0.4494	Yes
70	CHRNA7	CHRNA7 Entrez, Source	cholinergic receptor, nicotinic, alpha 7	4570	0.029	0.4517	Yes
71	KCNK10	KCNK10 Entrez, Source	potassium channel, subfamily K, member 10	4698	0.028	0.4468	No
72	CHRNE	CHRNE Entrez, Source	cholinergic receptor, nicotinic, epsilon	5036	0.023	0.4253	No
73	CHRNA6	CHRNA6 Entrez, Source	cholinergic receptor, nicotinic, alpha 6	5046	0.023	0.4285	No
74	CHRNA4	CHRNA4 Entrez, Source	cholinergic receptor, nicotinic, alpha 4	5066	0.023	0.4310	No
75	TRPC3	TRPC3 Entrez, Source	transient receptor potential cation channel, subfamily C, member 3	5195	0.022	0.4250	No
76	CACNA2D1	CACNA2D1 Entrez, Source	calcium channel, voltage-dependent, alpha 2/delta subunit 1	5197	0.022	0.4286	No
77	KCNC3	KCNC3 Entrez, Source	potassium voltage-gated channel, Shaw-related subfamily, member 3	5220	0.021	0.4306	No
78	CACNA1H	CACNA1H Entrez, Source	calcium channel, voltage-dependent, alpha 1H subunit	5379	0.019	0.4219	No
79	CLCNKB	CLCNKB Entrez, Source	chloride channel Kb	5381	0.019	0.4252	No
80	KCND3	KCND3 Entrez, Source	potassium voltage-gated channel, Shal-related subfamily, member 3	5549	0.018	0.4156	No
81	TRPM1	TRPM1 Entrez, Source	transient receptor potential cation channel, subfamily M, member 1	5659	0.017	0.4101	No
82	KCNK3	KCNK3 Entrez, Source	potassium channel, subfamily K, member 3	5875	0.014	0.3963	No
83	KCNN2	KCNN2 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	5943	0.013	0.3935	No
84	SCN4B	SCN4B Entrez, Source	sodium channel, voltage-gated, type IV, beta	5970	0.013	0.3938	No
85	KCNE2	KCNE2 Entrez, Source	potassium voltage-gated channel, Isk-related family, member 2	6032	0.012	0.3913	No
86	CACNA1E	CACNA1E Entrez, Source	calcium channel, voltage-dependent, alpha 1E subunit	6182	0.011	0.3819	No
87	TRPC4	TRPC4 Entrez, Source	transient receptor potential cation channel, subfamily C, member 4	6532	0.007	0.3567	No
88	FXYD3	FXYD3 Entrez, Source	FXYD domain containing ion transport regulator 3	6555	0.007	0.3562	No
89	KCNJ1	KCNJ1 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 1	6556	0.007	0.3574	No
90	KCNA3	KCNA3 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 3	6733	0.005	0.3450	No
91	KCNJ14	KCNJ14 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 14	6768	0.005	0.3432	No
92	CLCN3	CLCN3 Entrez, Source	chloride channel 3	6913	0.003	0.3328	No
93	CACNA1G	CACNA1G Entrez, Source	calcium channel, voltage-dependent, alpha 1G subunit	6925	0.003	0.3324	No
94	CFTR	CFTR Entrez, Source	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	7051	0.001	0.3232	No
95	P2RX3	P2RX3 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 3	7082	0.001	0.3211	No
96	P2RX1	P2RX1 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 1	7136	0.001	0.3172	No
97	RYR1	RYR1 Entrez, Source	ryanodine receptor 1 (skeletal)	7158	0.000	0.3157	No
98	KCNQ2	KCNQ2 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 2	7163	0.000	0.3154	No
99	CLCN2	CLCN2 Entrez, Source	chloride channel 2	7332	-0.002	0.3030	No
100	P2RX4	P2RX4 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 4	7423	-0.003	0.2967	No
101	KCNK1	KCNK1 Entrez, Source	potassium channel, subfamily K, member 1	7451	-0.003	0.2952	No
102	CNGB1	CNGB1 Entrez, Source	cyclic nucleotide gated channel beta 1	7546	-0.004	0.2888	No
103	KCNE1	KCNE1 Entrez, Source	potassium voltage-gated channel, Isk-related family, member 1	7817	-0.007	0.2696	No
104	SCN11A	SCN11A Entrez, Source	sodium channel, voltage-gated, type XI, alpha	8007	-0.010	0.2569	No
105	CHRNB4	CHRNB4 Entrez, Source	cholinergic receptor, nicotinic, beta 4	8203	-0.012	0.2442	No
106	P2RX2	P2RX2 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 2	8229	-0.012	0.2444	No
107	KCNJ3	KCNJ3 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 3	8268	-0.013	0.2437	No
108	CACNG1	CACNG1 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 1	8393	-0.014	0.2367	No
109	KCNH4	KCNH4 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 4	8439	-0.015	0.2358	No
110	CHRNB2	CHRNB2 Entrez, Source	cholinergic receptor, nicotinic, beta 2 (neuronal)	8576	-0.016	0.2283	No
111	KCNA4	KCNA4 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 4	8735	-0.018	0.2195	No
112	KCNJ6	KCNJ6 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 6	9027	-0.022	0.2013	No
113	KCNN4	KCNN4 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	9045	-0.023	0.2038	No
114	CNGA3	CNGA3 Entrez, Source	cyclic nucleotide gated channel alpha 3	9345	-0.027	0.1858	No
115	FXYD1	FXYD1 Entrez, Source	FXYD domain containing ion transport regulator 1 (phospholemman)	9863	-0.034	0.1525	No
116	CLCA2	CLCA2 Entrez, Source	chloride channel, calcium activated, family member 2	10051	-0.038	0.1447	No
117	KCNA1	KCNA1 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	10103	-0.038	0.1474	No
118	SCN1B	SCN1B Entrez, Source	sodium channel, voltage-gated, type I, beta	10150	-0.039	0.1506	No
119	KCNC1	KCNC1 Entrez, Source	potassium voltage-gated channel, Shaw-related subfamily, member 1	10154	-0.039	0.1571	No
120	CACNB2	CACNB2 Entrez, Source	calcium channel, voltage-dependent, beta 2 subunit	10205	-0.040	0.1602	No
121	SCN2B	SCN2B Entrez, Source	sodium channel, voltage-gated, type II, beta	10782	-0.051	0.1253	No
122	MS4A2	MS4A2 Entrez, Source	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	10839	-0.052	0.1300	No
123	CHRNB3	CHRNB3 Entrez, Source	cholinergic receptor, nicotinic, beta 3	10962	-0.055	0.1302	No
124	RYR2	RYR2 Entrez, Source	ryanodine receptor 2 (cardiac)	11214	-0.061	0.1215	No
125	TRPC1	TRPC1 Entrez, Source	transient receptor potential cation channel, subfamily C, member 1	12347	-0.107	0.0541	No
126	P2RX5	P2RX5 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 5	12575	-0.124	0.0580	No