Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | TGFBETA_ALL_UP |
| Enrichment Score (ES) | -0.5684784 |
| Normalized Enrichment Score (NES) | -1.8692272 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.02760665 |
| FWER p-Value | 0.779 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 351 | 0.142 | -0.0009 | No |
| 2 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 406 | 0.135 | 0.0193 | No |
| 3 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 1194 | 0.090 | -0.0237 | No |
| 4 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 1632 | 0.076 | -0.0429 | No |
| 5 | CDH6 | CDH6 Entrez, Source | cadherin 6, type 2, K-cadherin (fetal kidney) | 1638 | 0.076 | -0.0295 | No |
| 6 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 1657 | 0.075 | -0.0173 | No |
| 7 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 1840 | 0.071 | -0.0181 | No |
| 8 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 2001 | 0.068 | -0.0179 | No |
| 9 | ITGB2 | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 2233 | 0.063 | -0.0238 | No |
| 10 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 2407 | 0.060 | -0.0260 | No |
| 11 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 2588 | 0.057 | -0.0293 | No |
| 12 | IGFBP5 | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 2629 | 0.056 | -0.0221 | No |
| 13 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 2994 | 0.050 | -0.0405 | No |
| 14 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 3303 | 0.046 | -0.0554 | No |
| 15 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 3652 | 0.041 | -0.0742 | No |
| 16 | MTA1 | MTA1 Entrez, Source | metastasis associated 1 | 3816 | 0.039 | -0.0794 | No |
| 17 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 4709 | 0.027 | -0.1416 | No |
| 18 | DVL1 | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 5003 | 0.024 | -0.1594 | No |
| 19 | NID1 | NID1 Entrez, Source | nidogen 1 | 6040 | 0.012 | -0.2351 | No |
| 20 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 6296 | 0.010 | -0.2525 | No |
| 21 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 6323 | 0.009 | -0.2528 | No |
| 22 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 6389 | 0.009 | -0.2561 | No |
| 23 | FN1 | FN1 Entrez, Source | fibronectin 1 | 7215 | -0.000 | -0.3181 | No |
| 24 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 8158 | -0.011 | -0.3870 | No |
| 25 | SMO | SMO Entrez, Source | smoothened homolog (Drosophila) | 8225 | -0.012 | -0.3898 | No |
| 26 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 8686 | -0.018 | -0.4212 | No |
| 27 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8921 | -0.021 | -0.4350 | No |
| 28 | BSG | BSG Entrez, Source | basigin (Ok blood group) | 9210 | -0.025 | -0.4523 | No |
| 29 | EFNA5 | EFNA5 Entrez, Source | ephrin-A5 | 9580 | -0.030 | -0.4746 | No |
| 30 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 9608 | -0.031 | -0.4711 | No |
| 31 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 9751 | -0.033 | -0.4759 | No |
| 32 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 10584 | -0.047 | -0.5301 | No |
| 33 | JUP | JUP Entrez, Source | junction plakoglobin | 10892 | -0.053 | -0.5435 | No |
| 34 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10939 | -0.055 | -0.5372 | No |
| 35 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 11055 | -0.057 | -0.5355 | No |
| 36 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 11206 | -0.060 | -0.5359 | No |
| 37 | WNT2B | WNT2B Entrez, Source | wingless-type MMTV integration site family, member 2B | 11418 | -0.066 | -0.5400 | No |
| 38 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 11798 | -0.079 | -0.5543 | Yes |
| 39 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 11895 | -0.083 | -0.5465 | Yes |
| 40 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 12118 | -0.092 | -0.5466 | Yes |
| 41 | RHOG | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 12212 | -0.097 | -0.5360 | Yes |
| 42 | DSP | DSP Entrez, Source | desmoplakin | 12225 | -0.098 | -0.5192 | Yes |
| 43 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 12353 | -0.107 | -0.5094 | Yes |
| 44 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 12385 | -0.110 | -0.4919 | Yes |
| 45 | PXN | PXN Entrez, Source | paxillin | 12950 | -0.176 | -0.5027 | Yes |
| 46 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 12977 | -0.184 | -0.4715 | Yes |
| 47 | RHOQ | RHOQ Entrez, Source | ras homolog gene family, member Q | 13049 | -0.206 | -0.4397 | Yes |
| 48 | ZYX | ZYX Entrez, Source | zyxin | 13115 | -0.238 | -0.4016 | Yes |
| 49 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 13187 | -0.286 | -0.3555 | Yes |
| 50 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13241 | -0.343 | -0.2976 | Yes |
| 51 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13286 | -0.422 | -0.2249 | Yes |
| 52 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13308 | -0.484 | -0.1392 | Yes |
| 53 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 13335 | -0.786 | 0.0005 | Yes |
