Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | VERHAAK_AML_NPM1_MUT_VS_WT_DN |
| Enrichment Score (ES) | -0.45026743 |
| Normalized Enrichment Score (NES) | -1.6896513 |
| Nominal p-value | 0.0014992504 |
| FDR q-value | 0.071173824 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 176 | 0.182 | 0.0073 | No |
| 2 | H1F0 | H1F0 Entrez, Source | H1 histone family, member 0 | 274 | 0.154 | 0.0173 | No |
| 3 | RAMP1 | RAMP1 Entrez, Source | receptor (calcitonin) activity modifying protein 1 | 530 | 0.123 | 0.0119 | No |
| 4 | ROBO1 | ROBO1 Entrez, Source | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 737 | 0.109 | 0.0087 | No |
| 5 | LRP3 | LRP3 Entrez, Source | low density lipoprotein receptor-related protein 3 | 744 | 0.109 | 0.0206 | No |
| 6 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 827 | 0.106 | 0.0264 | No |
| 7 | FGFR1 | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 873 | 0.104 | 0.0347 | No |
| 8 | POU4F1 | POU4F1 Entrez, Source | POU domain, class 4, transcription factor 1 | 968 | 0.099 | 0.0388 | No |
| 9 | CD2 | CD2 Entrez, Source | CD2 molecule | 1336 | 0.085 | 0.0206 | No |
| 10 | ADCY3 | ADCY3 Entrez, Source | adenylate cyclase 3 | 1611 | 0.077 | 0.0085 | No |
| 11 | TPSAB1 | TPSAB1 Entrez, Source | tryptase alpha/beta 1 | 1806 | 0.072 | 0.0020 | No |
| 12 | ELA2 | ELA2 Entrez, Source | elastase 2, neutrophil | 1838 | 0.071 | 0.0077 | No |
| 13 | ST18 | ST18 Entrez, Source | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) | 1852 | 0.071 | 0.0147 | No |
| 14 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 1883 | 0.070 | 0.0204 | No |
| 15 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 1951 | 0.069 | 0.0232 | No |
| 16 | PALM | PALM Entrez, Source | paralemmin | 1966 | 0.069 | 0.0299 | No |
| 17 | DPYSL2 | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 2027 | 0.067 | 0.0330 | No |
| 18 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 2175 | 0.064 | 0.0291 | No |
| 19 | AK3L1 | AK3L1 Entrez, Source | adenylate kinase 3-like 1 | 2337 | 0.061 | 0.0239 | No |
| 20 | NRXN2 | NRXN2 Entrez, Source | neurexin 2 | 2567 | 0.057 | 0.0131 | No |
| 21 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 2588 | 0.057 | 0.0180 | No |
| 22 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 2696 | 0.055 | 0.0161 | No |
| 23 | CD3D | CD3D Entrez, Source | CD3d molecule, delta (CD3-TCR complex) | 2816 | 0.053 | 0.0131 | No |
| 24 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 2878 | 0.052 | 0.0144 | No |
| 25 | ASS1 | ASS1 Entrez, Source | argininosuccinate synthetase 1 | 3063 | 0.049 | 0.0060 | No |
| 26 | TMEM158 | TMEM158 Entrez, Source | transmembrane protein 158 | 3086 | 0.049 | 0.0099 | No |
| 27 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 3226 | 0.047 | 0.0047 | No |
| 28 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3232 | 0.047 | 0.0096 | No |
| 29 | GPM6B | GPM6B Entrez, Source | glycoprotein M6B | 3271 | 0.046 | 0.0119 | No |
| 30 | FCER1A | FCER1A Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 3426 | 0.044 | 0.0053 | No |
| 31 | NPR3 | NPR3 Entrez, Source | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | 3545 | 0.042 | 0.0011 | No |
| 32 | RUNX3 | RUNX3 Entrez, Source | runt-related transcription factor 3 | 3587 | 0.042 | 0.0027 | No |
| 33 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 3627 | 0.041 | 0.0045 | No |
| 34 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3843 | 0.039 | -0.0074 | No |
| 35 | BLNK | BLNK Entrez, Source | B-cell linker | 3887 | 0.038 | -0.0063 | No |
| 36 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 3898 | 0.038 | -0.0028 | No |
| 37 | HPGD | HPGD Entrez, Source | hydroxyprostaglandin dehydrogenase 15-(NAD) | 3915 | 0.038 | 0.0002 | No |
| 38 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 4024 | 0.036 | -0.0039 | No |
| 39 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 4134 | 0.035 | -0.0082 | No |
| 40 | PRODH | PRODH Entrez, Source | proline dehydrogenase (oxidase) 1 | 4210 | 0.034 | -0.0101 | No |
| 41 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 4229 | 0.033 | -0.0077 | No |
| 42 | GNG7 | GNG7 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 7 | 4266 | 0.033 | -0.0067 | No |
| 43 | CD200 | CD200 Entrez, Source | CD200 molecule | 4766 | 0.027 | -0.0414 | No |
| 44 | MST1 | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 4770 | 0.027 | -0.0386 | No |
| 45 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 4783 | 0.027 | -0.0365 | No |
| 46 | CIITA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 4792 | 0.026 | -0.0341 | No |
| 47 | FZD6 | FZD6 Entrez, Source | frizzled homolog 6 (Drosophila) | 4814 | 0.026 | -0.0328 | No |
| 48 | MLLT3 | MLLT3 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 5005 | 0.024 | -0.0445 | No |
| 49 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 5075 | 0.023 | -0.0471 | No |
| 50 | DLK1 | DLK1 Entrez, Source | delta-like 1 homolog (Drosophila) | 5246 | 0.021 | -0.0576 | No |
| 51 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 5398 | 0.019 | -0.0668 | No |
| 52 | BAALC | BAALC Entrez, Source | brain and acute leukemia, cytoplasmic | 5452 | 0.019 | -0.0687 | No |
| 53 | SLC38A1 | SLC38A1 Entrez, Source | solute carrier family 38, member 1 | 5607 | 0.017 | -0.0785 | No |
| 54 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 5622 | 0.017 | -0.0776 | No |
| 55 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 5771 | 0.015 | -0.0871 | No |
| 56 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5897 | 0.014 | -0.0950 | No |
| 57 | BZRAP1 | BZRAP1 Entrez, Source | benzodiazapine receptor (peripheral) associated protein 1 | 5900 | 0.014 | -0.0935 | No |
| 58 | ARHGEF12 | ARHGEF12 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 12 | 5956 | 0.013 | -0.0962 | No |
| 59 | C1ORF24 | C1ORF24 Entrez, Source | chromosome 1 open reading frame 24 | 6174 | 0.011 | -0.1114 | No |
| 60 | ERG | ERG Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 6202 | 0.011 | -0.1122 | No |
| 61 | CD38 | CD38 Entrez, Source | CD38 molecule | 6335 | 0.009 | -0.1211 | No |
| 62 | SCCPDH | SCCPDH Entrez, Source | saccharopine dehydrogenase (putative) | 6412 | 0.008 | -0.1259 | No |
| 63 | LMO4 | LMO4 Entrez, Source | LIM domain only 4 | 6509 | 0.007 | -0.1323 | No |
| 64 | RAP2A | RAP2A Entrez, Source | RAP2A, member of RAS oncogene family | 6666 | 0.006 | -0.1435 | No |
| 65 | EHD3 | EHD3 Entrez, Source | EH-domain containing 3 | 7093 | 0.001 | -0.1756 | No |
| 66 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 7114 | 0.001 | -0.1770 | No |
| 67 | TGFB1I1 | TGFB1I1 Entrez, Source | transforming growth factor beta 1 induced transcript 1 | 7121 | 0.001 | -0.1774 | No |
| 68 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 7134 | 0.001 | -0.1782 | No |
| 69 | FGF13 | FGF13 Entrez, Source | fibroblast growth factor 13 | 7212 | -0.000 | -0.1840 | No |
| 70 | BPGM | BPGM Entrez, Source | 2,3-bisphosphoglycerate mutase | 7240 | -0.001 | -0.1860 | No |
| 71 | IL5RA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 7277 | -0.001 | -0.1886 | No |
| 72 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 7586 | -0.005 | -0.2114 | No |
| 73 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 7644 | -0.005 | -0.2151 | No |
| 74 | TRH | TRH Entrez, Source | thyrotropin-releasing hormone | 7651 | -0.005 | -0.2149 | No |
| 75 | TRPM4 | TRPM4 Entrez, Source | transient receptor potential cation channel, subfamily M, member 4 | 7661 | -0.005 | -0.2150 | No |
| 76 | NARFL | NARFL Entrez, Source | nuclear prelamin A recognition factor-like | 7803 | -0.007 | -0.2249 | No |
| 77 | MSLN | MSLN Entrez, Source | mesothelin | 7901 | -0.008 | -0.2313 | No |
| 78 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 8082 | -0.010 | -0.2437 | No |
| 79 | NT5E | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 8154 | -0.011 | -0.2478 | No |
| 80 | SYNGR1 | SYNGR1 Entrez, Source | synaptogyrin 1 | 8181 | -0.012 | -0.2485 | No |
| 81 | NCAM1 | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 8309 | -0.013 | -0.2566 | No |
| 82 | EGFL7 | EGFL7 Entrez, Source | EGF-like-domain, multiple 7 | 8451 | -0.015 | -0.2656 | No |
| 83 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 8630 | -0.017 | -0.2771 | No |
| 84 | OPTN | OPTN Entrez, Source | optineurin | 8689 | -0.018 | -0.2795 | No |
| 85 | ALAS2 | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 8816 | -0.019 | -0.2868 | No |
| 86 | PTPRM | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 8923 | -0.021 | -0.2925 | No |
| 87 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 8929 | -0.021 | -0.2905 | No |
| 88 | GMPR | GMPR Entrez, Source | guanosine monophosphate reductase | 8980 | -0.022 | -0.2918 | No |
| 89 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 9974 | -0.036 | -0.3628 | No |
| 90 | CYP2E1 | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 10268 | -0.041 | -0.3804 | No |
| 91 | SNRPN /// SNURF | 10327 | -0.042 | -0.3800 | No | ||
| 92 | ADIPOR1 | ADIPOR1 Entrez, Source | adiponectin receptor 1 | 10701 | -0.049 | -0.4027 | No |
| 93 | CD48 | CD48 Entrez, Source | CD48 molecule | 10831 | -0.052 | -0.4065 | No |
| 94 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 10868 | -0.053 | -0.4033 | No |
| 95 | JUP | JUP Entrez, Source | junction plakoglobin | 10892 | -0.053 | -0.3990 | No |
| 96 | CCR2 | CCR2 Entrez, Source | chemokine (C-C motif) receptor 2 | 11014 | -0.056 | -0.4018 | No |
| 97 | FZD2 | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 11656 | -0.074 | -0.4419 | Yes |
| 98 | B4GALT6 | B4GALT6 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 11749 | -0.077 | -0.4401 | Yes |
| 99 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 11831 | -0.081 | -0.4372 | Yes |
| 100 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 11932 | -0.084 | -0.4352 | Yes |
| 101 | PDE3B | PDE3B Entrez, Source | phosphodiesterase 3B, cGMP-inhibited | 12115 | -0.092 | -0.4385 | Yes |
| 102 | PROM1 | PROM1 Entrez, Source | prominin 1 | 12141 | -0.094 | -0.4298 | Yes |
| 103 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12230 | -0.098 | -0.4254 | Yes |
| 104 | F2RL1 | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 12440 | -0.114 | -0.4283 | Yes |
| 105 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 12519 | -0.119 | -0.4208 | Yes |
| 106 | PTGER4 | PTGER4 Entrez, Source | prostaglandin E receptor 4 (subtype EP4) | 12537 | -0.120 | -0.4085 | Yes |
| 107 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 12575 | -0.124 | -0.3973 | Yes |
| 108 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 12691 | -0.134 | -0.3909 | Yes |
| 109 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12716 | -0.137 | -0.3772 | Yes |
| 110 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 12808 | -0.149 | -0.3673 | Yes |
| 111 | NBL1 | NBL1 Entrez, Source | neuroblastoma, suppression of tumorigenicity 1 | 12818 | -0.150 | -0.3510 | Yes |
| 112 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 12821 | -0.151 | -0.3341 | Yes |
| 113 | PDE4B | PDE4B Entrez, Source | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | 12954 | -0.177 | -0.3241 | Yes |
| 114 | TMOD1 | TMOD1 Entrez, Source | tropomodulin 1 | 12990 | -0.186 | -0.3057 | Yes |
| 115 | SCRN1 | SCRN1 Entrez, Source | secernin 1 | 12993 | -0.186 | -0.2848 | Yes |
| 116 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13024 | -0.196 | -0.2649 | Yes |
| 117 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13025 | -0.196 | -0.2427 | Yes |
| 118 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 13105 | -0.234 | -0.2222 | Yes |
| 119 | VLDLR | VLDLR Entrez, Source | very low density lipoprotein receptor | 13129 | -0.246 | -0.1962 | Yes |
| 120 | SERINC5 | SERINC5 Entrez, Source | serine incorporator 5 | 13209 | -0.303 | -0.1679 | Yes |
| 121 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13213 | -0.306 | -0.1336 | Yes |
| 122 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13239 | -0.335 | -0.0976 | Yes |
| 123 | CD69 | CD69 Entrez, Source | CD69 molecule | 13297 | -0.457 | -0.0503 | Yes |
| 124 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 13304 | -0.474 | 0.0029 | Yes |
