Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | VOLTAGE_GATED_CHANNEL_ACTIVITY |
| Enrichment Score (ES) | 0.50402486 |
| Normalized Enrichment Score (NES) | 1.8877791 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.017375264 |
| FWER p-Value | 0.59 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 215 | 0.170 | 0.0451 | Yes |
| 2 | NOX1 | NOX1 Entrez, Source | NADPH oxidase 1 | 373 | 0.139 | 0.0834 | Yes |
| 3 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 690 | 0.112 | 0.1002 | Yes |
| 4 | CLCN1 | CLCN1 Entrez, Source | chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) | 713 | 0.111 | 0.1386 | Yes |
| 5 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 980 | 0.098 | 0.1540 | Yes |
| 6 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 1373 | 0.083 | 0.1546 | Yes |
| 7 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 1403 | 0.083 | 0.1823 | Yes |
| 8 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 1472 | 0.080 | 0.2061 | Yes |
| 9 | KCNK15 | KCNK15 Entrez, Source | potassium channel, subfamily K, member 15 | 1594 | 0.077 | 0.2249 | Yes |
| 10 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 1635 | 0.076 | 0.2494 | Yes |
| 11 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 1827 | 0.072 | 0.2608 | Yes |
| 12 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 1871 | 0.071 | 0.2831 | Yes |
| 13 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 1971 | 0.069 | 0.3005 | Yes |
| 14 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 2059 | 0.067 | 0.3180 | Yes |
| 15 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 2156 | 0.065 | 0.3341 | Yes |
| 16 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 2194 | 0.064 | 0.3545 | Yes |
| 17 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 2409 | 0.060 | 0.3601 | Yes |
| 18 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 2443 | 0.060 | 0.3791 | Yes |
| 19 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 2467 | 0.059 | 0.3987 | Yes |
| 20 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 2922 | 0.051 | 0.3831 | Yes |
| 21 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3006 | 0.050 | 0.3949 | Yes |
| 22 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 3213 | 0.047 | 0.3963 | Yes |
| 23 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 3252 | 0.046 | 0.4102 | Yes |
| 24 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 3309 | 0.046 | 0.4225 | Yes |
| 25 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 3318 | 0.046 | 0.4383 | Yes |
| 26 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 3321 | 0.045 | 0.4546 | Yes |
| 27 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 3538 | 0.042 | 0.4536 | Yes |
| 28 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 3690 | 0.041 | 0.4569 | Yes |
| 29 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 3973 | 0.037 | 0.4490 | Yes |
| 30 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 4055 | 0.036 | 0.4557 | Yes |
| 31 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 4117 | 0.035 | 0.4637 | Yes |
| 32 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 4260 | 0.033 | 0.4649 | Yes |
| 33 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 4296 | 0.033 | 0.4741 | Yes |
| 34 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 4301 | 0.033 | 0.4855 | Yes |
| 35 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 4340 | 0.032 | 0.4943 | Yes |
| 36 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 4364 | 0.032 | 0.5040 | Yes |
| 37 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 5197 | 0.022 | 0.4491 | No |
| 38 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 5220 | 0.021 | 0.4551 | No |
| 39 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 5379 | 0.019 | 0.4503 | No |
| 40 | CLCNKB | CLCNKB Entrez, Source | chloride channel Kb | 5381 | 0.019 | 0.4572 | No |
| 41 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 5549 | 0.018 | 0.4511 | No |
| 42 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 5970 | 0.013 | 0.4241 | No |
| 43 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 6032 | 0.012 | 0.4241 | No |
| 44 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 6182 | 0.011 | 0.4168 | No |
| 45 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 6556 | 0.007 | 0.3913 | No |
| 46 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 6733 | 0.005 | 0.3798 | No |
| 47 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 6768 | 0.005 | 0.3789 | No |
| 48 | CLCN3 | CLCN3 Entrez, Source | chloride channel 3 | 6913 | 0.003 | 0.3691 | No |
| 49 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 6925 | 0.003 | 0.3693 | No |
| 50 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 7163 | 0.000 | 0.3515 | No |
| 51 | CLCN2 | CLCN2 Entrez, Source | chloride channel 2 | 7332 | -0.002 | 0.3395 | No |
| 52 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 7451 | -0.003 | 0.3317 | No |
| 53 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 7817 | -0.007 | 0.3069 | No |
| 54 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 8007 | -0.010 | 0.2961 | No |
| 55 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 8268 | -0.013 | 0.2811 | No |
| 56 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 8393 | -0.014 | 0.2768 | No |
| 57 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 8439 | -0.015 | 0.2788 | No |
| 58 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 8735 | -0.018 | 0.2633 | No |
| 59 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 9027 | -0.022 | 0.2494 | No |
| 60 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 10103 | -0.038 | 0.1823 | No |
| 61 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 10150 | -0.039 | 0.1930 | No |
| 62 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 10154 | -0.039 | 0.2070 | No |
| 63 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 10205 | -0.040 | 0.2177 | No |
| 64 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 10782 | -0.051 | 0.1928 | No |
