Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | ACTIN_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS |
| Enrichment Score (ES) | -0.5711428 |
| Normalized Enrichment Score (NES) | -1.807921 |
| Nominal p-value | 0.0017271157 |
| FDR q-value | 0.036202364 |
| FWER p-Value | 0.947 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 50 | 0.500 | 0.0624 | No |
| 2 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 1137 | 0.135 | -0.0015 | No |
| 3 | SCIN | SCIN Entrez, Source | scinderin | 1491 | 0.114 | -0.0130 | No |
| 4 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 2131 | 0.090 | -0.0492 | No |
| 5 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 2178 | 0.089 | -0.0409 | No |
| 6 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 2338 | 0.084 | -0.0418 | No |
| 7 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 2783 | 0.072 | -0.0657 | No |
| 8 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 2930 | 0.068 | -0.0677 | No |
| 9 | NUAK2 | NUAK2 Entrez, Source | NUAK family, SNF1-like kinase, 2 | 3483 | 0.056 | -0.1018 | No |
| 10 | TESK2 | TESK2 Entrez, Source | testis-specific kinase 2 | 3813 | 0.050 | -0.1200 | No |
| 11 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 4951 | 0.030 | -0.2017 | No |
| 12 | TSC1 | TSC1 Entrez, Source | tuberous sclerosis 1 | 4962 | 0.030 | -0.1985 | No |
| 13 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 5321 | 0.024 | -0.2222 | No |
| 14 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5854 | 0.016 | -0.2601 | No |
| 15 | TTN | TTN Entrez, Source | titin | 5994 | 0.014 | -0.2687 | No |
| 16 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 6018 | 0.014 | -0.2686 | No |
| 17 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 6233 | 0.011 | -0.2832 | No |
| 18 | PACSIN2 | PACSIN2 Entrez, Source | protein kinase C and casein kinase substrate in neurons 2 | 6347 | 0.009 | -0.2906 | No |
| 19 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 6721 | 0.004 | -0.3182 | No |
| 20 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 6958 | 0.000 | -0.3359 | No |
| 21 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 7002 | -0.000 | -0.3391 | No |
| 22 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 7143 | -0.002 | -0.3493 | No |
| 23 | GHRL | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 7982 | -0.015 | -0.4105 | No |
| 24 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 8191 | -0.018 | -0.4238 | No |
| 25 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 8576 | -0.024 | -0.4495 | No |
| 26 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8581 | -0.024 | -0.4465 | No |
| 27 | PLA2G1B | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 8831 | -0.029 | -0.4615 | No |
| 28 | GHSR | GHSR Entrez, Source | growth hormone secretagogue receptor | 8872 | -0.029 | -0.4606 | No |
| 29 | LIMK1 | LIMK1 Entrez, Source | LIM domain kinase 1 | 9254 | -0.037 | -0.4844 | No |
| 30 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 9266 | -0.037 | -0.4803 | No |
| 31 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9430 | -0.040 | -0.4873 | No |
| 32 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 9556 | -0.043 | -0.4910 | No |
| 33 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 10116 | -0.055 | -0.5259 | No |
| 34 | TAOK2 | TAOK2 Entrez, Source | TAO kinase 2 | 10217 | -0.057 | -0.5258 | No |
| 35 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 10349 | -0.060 | -0.5277 | No |
| 36 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10733 | -0.071 | -0.5472 | No |
| 37 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 10829 | -0.073 | -0.5447 | No |
| 38 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 10847 | -0.074 | -0.5362 | No |
| 39 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 11231 | -0.087 | -0.5535 | No |
| 40 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11466 | -0.098 | -0.5582 | Yes |
| 41 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 11553 | -0.102 | -0.5512 | Yes |
| 42 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 11799 | -0.114 | -0.5546 | Yes |
| 43 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 11882 | -0.118 | -0.5451 | Yes |
| 44 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 11988 | -0.124 | -0.5367 | Yes |
| 45 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 12011 | -0.126 | -0.5217 | Yes |
| 46 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 12086 | -0.130 | -0.5100 | Yes |
| 47 | PSCD2 | PSCD2 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) | 12232 | -0.142 | -0.5021 | Yes |
| 48 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12398 | -0.157 | -0.4937 | Yes |
| 49 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12456 | -0.165 | -0.4762 | Yes |
| 50 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 12492 | -0.169 | -0.4565 | Yes |
| 51 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 12675 | -0.199 | -0.4438 | Yes |
| 52 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12715 | -0.208 | -0.4192 | Yes |
| 53 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12779 | -0.218 | -0.3951 | Yes |
| 54 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 12803 | -0.226 | -0.3670 | Yes |
| 55 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 12818 | -0.229 | -0.3378 | Yes |
| 56 | CDC42EP2 | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 13063 | -0.326 | -0.3131 | Yes |
| 57 | DBN1 | DBN1 Entrez, Source | drebrin 1 | 13318 | -0.939 | -0.2080 | Yes |
| 58 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.586 | 0.0002 | Yes |
