Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | AGEING_KIDNEY_SPECIFIC_DN |
| Enrichment Score (ES) | 0.41263255 |
| Normalized Enrichment Score (NES) | 1.4738649 |
| Nominal p-value | 0.014814815 |
| FDR q-value | 0.13784595 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DHTKD1 | DHTKD1 Entrez, Source | dehydrogenase E1 and transketolase domain containing 1 | 74 | 0.447 | 0.0553 | Yes |
| 2 | SULT1C1 | SULT1C1 Entrez, Source | sulfotransferase family, cytosolic, 1C, member 1 | 148 | 0.356 | 0.0984 | Yes |
| 3 | GHR | GHR Entrez, Source | growth hormone receptor | 250 | 0.287 | 0.1300 | Yes |
| 4 | SRR | SRR Entrez, Source | serine racemase | 268 | 0.279 | 0.1668 | Yes |
| 5 | ALDH6A1 | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 445 | 0.217 | 0.1831 | Yes |
| 6 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 651 | 0.179 | 0.1921 | Yes |
| 7 | LRPPRC | LRPPRC Entrez, Source | leucine-rich PPR-motif containing | 838 | 0.159 | 0.1997 | Yes |
| 8 | OAT | OAT Entrez, Source | ornithine aminotransferase (gyrate atrophy) | 893 | 0.154 | 0.2166 | Yes |
| 9 | LTB4DH | LTB4DH Entrez, Source | leukotriene B4 12-hydroxydehydrogenase | 931 | 0.151 | 0.2344 | Yes |
| 10 | HBLD2 | HBLD2 Entrez, Source | HESB like domain containing 2 | 1036 | 0.141 | 0.2458 | Yes |
| 11 | PECI | PECI Entrez, Source | peroxisomal D3,D2-enoyl-CoA isomerase | 1151 | 0.133 | 0.2554 | Yes |
| 12 | PALM | PALM Entrez, Source | paralemmin | 1230 | 0.128 | 0.2669 | Yes |
| 13 | MTR | MTR Entrez, Source | 5-methyltetrahydrofolate-homocysteine methyltransferase | 1239 | 0.127 | 0.2837 | Yes |
| 14 | HIBADH | HIBADH Entrez, Source | 3-hydroxyisobutyrate dehydrogenase | 1384 | 0.120 | 0.2892 | Yes |
| 15 | AMT | AMT Entrez, Source | aminomethyltransferase | 1397 | 0.119 | 0.3044 | Yes |
| 16 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 1556 | 0.110 | 0.3076 | Yes |
| 17 | TMEM80 | TMEM80 Entrez, Source | transmembrane protein 80 | 1706 | 0.105 | 0.3107 | Yes |
| 18 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1748 | 0.103 | 0.3216 | Yes |
| 19 | NDUFS1 | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 1817 | 0.101 | 0.3302 | Yes |
| 20 | PHYH | PHYH Entrez, Source | phytanoyl-CoA 2-hydroxylase | 2036 | 0.093 | 0.3265 | Yes |
| 21 | COX7B | COX7B Entrez, Source | cytochrome c oxidase subunit VIIb | 2157 | 0.089 | 0.3296 | Yes |
| 22 | CYB5A | CYB5A Entrez, Source | cytochrome b5 type A (microsomal) | 2179 | 0.089 | 0.3402 | Yes |
| 23 | ITPR1 | ITPR1 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 1 | 2186 | 0.089 | 0.3518 | Yes |
| 24 | ISOC1 | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 2314 | 0.085 | 0.3538 | Yes |
| 25 | THRB | THRB Entrez, Source | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | 2315 | 0.085 | 0.3653 | Yes |
| 26 | CLDN8 | CLDN8 Entrez, Source | claudin 8 | 2374 | 0.083 | 0.3723 | Yes |
| 27 | PTPRO | PTPRO Entrez, Source | protein tyrosine phosphatase, receptor type, O | 2417 | 0.082 | 0.3803 | Yes |
| 28 | AK2 | AK2 Entrez, Source | adenylate kinase 2 | 2453 | 0.081 | 0.3887 | Yes |
| 29 | NEDD4L | NEDD4L Entrez, Source | neural precursor cell expressed, developmentally down-regulated 4-like | 2471 | 0.081 | 0.3984 | Yes |
| 30 | BCAN | BCAN Entrez, Source | brevican | 2679 | 0.074 | 0.3929 | Yes |
| 31 | TMPRSS2 | TMPRSS2 Entrez, Source | transmembrane protease, serine 2 | 2687 | 0.074 | 0.4024 | Yes |
| 32 | APLP2 | APLP2 Entrez, Source | amyloid beta (A4) precursor-like protein 2 | 2711 | 0.073 | 0.4107 | Yes |
| 33 | GNAS | GNAS Entrez, Source | GNAS complex locus | 2815 | 0.071 | 0.4126 | Yes |
| 34 | IGF1R | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 3241 | 0.061 | 0.3890 | No |
| 35 | COX8A | COX8A Entrez, Source | cytochrome c oxidase subunit 8A (ubiquitous) | 3448 | 0.057 | 0.3812 | No |
| 36 | ATP5A1 | ATP5A1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 3850 | 0.049 | 0.3577 | No |
| 37 | DBT | DBT Entrez, Source | dihydrolipoamide branched chain transacylase E2 | 3912 | 0.048 | 0.3597 | No |
| 38 | BRP44L | BRP44L Entrez, Source | brain protein 44-like | 3994 | 0.046 | 0.3599 | No |
| 39 | PRKAA2 | PRKAA2 Entrez, Source | protein kinase, AMP-activated, alpha 2 catalytic subunit | 4141 | 0.044 | 0.3549 | No |
| 40 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 4162 | 0.044 | 0.3593 | No |
| 41 | ATP5G3 | ATP5G3 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) | 4222 | 0.043 | 0.3607 | No |
| 42 | PRDX3 | PRDX3 Entrez, Source | peroxiredoxin 3 | 4271 | 0.042 | 0.3628 | No |
| 43 | HADHB | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 4675 | 0.035 | 0.3371 | No |
| 44 | COX6C | COX6C Entrez, Source | cytochrome c oxidase subunit VIc | 5036 | 0.029 | 0.3139 | No |
| 45 | PEBP1 | PEBP1 Entrez, Source | phosphatidylethanolamine binding protein 1 | 5190 | 0.026 | 0.3060 | No |
| 46 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 5916 | 0.015 | 0.2535 | No |
| 47 | WDR61 | WDR61 Entrez, Source | WD repeat domain 61 | 5970 | 0.015 | 0.2515 | No |
| 48 | PCLO | PCLO Entrez, Source | piccolo (presynaptic cytomatrix protein) | 6297 | 0.010 | 0.2282 | No |
| 49 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6707 | 0.004 | 0.1979 | No |
| 50 | FMO5 | FMO5 Entrez, Source | flavin containing monooxygenase 5 | 7369 | -0.006 | 0.1489 | No |
| 51 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 8665 | -0.026 | 0.0549 | No |
| 52 | GPHN | GPHN Entrez, Source | gephyrin | 9059 | -0.033 | 0.0298 | No |
| 53 | ESRRG | ESRRG Entrez, Source | estrogen-related receptor gamma | 9512 | -0.042 | 0.0015 | No |
| 54 | PCBP2 | PCBP2 Entrez, Source | poly(rC) binding protein 2 | 10047 | -0.053 | -0.0315 | No |
| 55 | SHANK2 | SHANK2 Entrez, Source | SH3 and multiple ankyrin repeat domains 2 | 10101 | -0.054 | -0.0281 | No |
| 56 | GSTM4 | GSTM4 Entrez, Source | glutathione S-transferase M4 | 10178 | -0.056 | -0.0262 | No |
| 57 | RAB40C | RAB40C Entrez, Source | RAB40C, member RAS oncogene family | 10326 | -0.060 | -0.0291 | No |
| 58 | LPL | LPL Entrez, Source | lipoprotein lipase | 10988 | -0.078 | -0.0682 | No |
| 59 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 10995 | -0.078 | -0.0580 | No |
| 60 | PPP2R1B | PPP2R1B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | 11399 | -0.095 | -0.0754 | No |
| 61 | CLASP2 | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 11749 | -0.111 | -0.0865 | No |
| 62 | GSTA4 | GSTA4 Entrez, Source | glutathione S-transferase A4 | 11757 | -0.112 | -0.0718 | No |
| 63 | ABCA5 | ABCA5 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 5 | 12067 | -0.129 | -0.0775 | No |
| 64 | IMPACT | IMPACT Entrez, Source | Impact homolog (mouse) | 12240 | -0.143 | -0.0710 | No |
| 65 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 13034 | -0.309 | -0.0885 | No |
| 66 | KLHL24 | KLHL24 Entrez, Source | kelch-like 24 (Drosophila) | 13056 | -0.323 | -0.0460 | No |
| 67 | RTN4 | RTN4 Entrez, Source | reticulon 4 | 13219 | -0.495 | 0.0093 | No |
