Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | AGEING_KIDNEY_SPECIFIC_UP |
| Enrichment Score (ES) | -0.49558643 |
| Normalized Enrichment Score (NES) | -1.7593508 |
| Nominal p-value | 0.0016207455 |
| FDR q-value | 0.04449778 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 49 | 0.501 | 0.0238 | No |
| 2 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 58 | 0.484 | 0.0498 | No |
| 3 | CFB | CFB Entrez, Source | complement factor B | 107 | 0.413 | 0.0689 | No |
| 4 | RARRES1 | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 239 | 0.290 | 0.0750 | No |
| 5 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 253 | 0.286 | 0.0897 | No |
| 6 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 383 | 0.238 | 0.0931 | No |
| 7 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 557 | 0.191 | 0.0905 | No |
| 8 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 754 | 0.167 | 0.0849 | No |
| 9 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 834 | 0.159 | 0.0877 | No |
| 10 | CRELD2 | CRELD2 Entrez, Source | cysteine-rich with EGF-like domains 2 | 1096 | 0.137 | 0.0755 | No |
| 11 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 1194 | 0.130 | 0.0753 | No |
| 12 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 1197 | 0.130 | 0.0823 | No |
| 13 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1340 | 0.122 | 0.0783 | No |
| 14 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 1390 | 0.119 | 0.0812 | No |
| 15 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 1401 | 0.119 | 0.0870 | No |
| 16 | C3 | C3 Entrez, Source | complement component 3 | 1475 | 0.114 | 0.0877 | No |
| 17 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 1605 | 0.109 | 0.0840 | No |
| 18 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 1619 | 0.108 | 0.0889 | No |
| 19 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 2125 | 0.090 | 0.0557 | No |
| 20 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 2208 | 0.088 | 0.0544 | No |
| 21 | UBD | UBD Entrez, Source | ubiquitin D | 2423 | 0.082 | 0.0427 | No |
| 22 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 2717 | 0.073 | 0.0246 | No |
| 23 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 2826 | 0.071 | 0.0203 | No |
| 24 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3307 | 0.060 | -0.0127 | No |
| 25 | CXCL14 | CXCL14 Entrez, Source | chemokine (C-X-C motif) ligand 14 | 3372 | 0.059 | -0.0143 | No |
| 26 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 3443 | 0.057 | -0.0165 | No |
| 27 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 3450 | 0.057 | -0.0138 | No |
| 28 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 3536 | 0.055 | -0.0172 | No |
| 29 | TMED3 | TMED3 Entrez, Source | transmembrane emp24 protein transport domain containing 3 | 3590 | 0.054 | -0.0182 | No |
| 30 | CTHRC1 | CTHRC1 Entrez, Source | collagen triple helix repeat containing 1 | 3598 | 0.054 | -0.0158 | No |
| 31 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 3644 | 0.053 | -0.0163 | No |
| 32 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 3715 | 0.052 | -0.0187 | No |
| 33 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 3828 | 0.049 | -0.0245 | No |
| 34 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3864 | 0.049 | -0.0244 | No |
| 35 | RPN1 | RPN1 Entrez, Source | ribophorin I | 4101 | 0.045 | -0.0398 | No |
| 36 | ASNS | ASNS Entrez, Source | asparagine synthetase | 4245 | 0.042 | -0.0483 | No |
| 37 | RPN2 | RPN2 Entrez, Source | ribophorin II | 4397 | 0.040 | -0.0575 | No |
| 38 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 4616 | 0.036 | -0.0720 | No |
| 39 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 4821 | 0.032 | -0.0857 | No |
| 40 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 4974 | 0.030 | -0.0955 | No |
| 41 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 5022 | 0.029 | -0.0975 | No |
| 42 | EBF1 | EBF1 Entrez, Source | early B-cell factor 1 | 5224 | 0.026 | -0.1113 | No |
| 43 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 5241 | 0.026 | -0.1111 | No |
| 44 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 5918 | 0.015 | -0.1613 | No |
| 45 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 5999 | 0.014 | -0.1666 | No |
| 46 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 6099 | 0.013 | -0.1734 | No |
| 47 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 6368 | 0.008 | -0.1932 | No |
| 48 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 7132 | -0.002 | -0.2507 | No |
| 49 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 8051 | -0.016 | -0.3192 | No |
| 50 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 8175 | -0.018 | -0.3275 | No |
| 51 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 8404 | -0.021 | -0.3436 | No |
| 52 | SPARCL1 | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 8609 | -0.025 | -0.3577 | No |
| 53 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 8840 | -0.029 | -0.3734 | No |
| 54 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 8857 | -0.029 | -0.3731 | No |
| 55 | SYMPK | SYMPK Entrez, Source | symplekin | 8892 | -0.030 | -0.3740 | No |
| 56 | MOXD1 | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 9001 | -0.032 | -0.3804 | No |
| 57 | VTCN1 | VTCN1 Entrez, Source | V-set domain containing T cell activation inhibitor 1 | 9232 | -0.036 | -0.3958 | No |
| 58 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 9367 | -0.039 | -0.4037 | No |
| 59 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 9756 | -0.047 | -0.4305 | No |
| 60 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 9787 | -0.048 | -0.4301 | No |
| 61 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 9955 | -0.051 | -0.4399 | No |
| 62 | FEZ2 | FEZ2 Entrez, Source | fasciculation and elongation protein zeta 2 (zygin II) | 9964 | -0.051 | -0.4377 | No |
| 63 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 10011 | -0.052 | -0.4383 | No |
| 64 | FN1 | FN1 Entrez, Source | fibronectin 1 | 10062 | -0.053 | -0.4392 | No |
| 65 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 10094 | -0.054 | -0.4385 | No |
| 66 | PLOD3 | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 10122 | -0.055 | -0.4375 | No |
| 67 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 10349 | -0.060 | -0.4513 | No |
| 68 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 10633 | -0.068 | -0.4690 | No |
| 69 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 10829 | -0.073 | -0.4797 | No |
| 70 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 10850 | -0.074 | -0.4771 | No |
| 71 | COL27A1 | COL27A1 Entrez, Source | collagen, type XXVII, alpha 1 | 11003 | -0.079 | -0.4843 | No |
| 72 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 11055 | -0.080 | -0.4837 | No |
| 73 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 11213 | -0.086 | -0.4908 | Yes |
| 74 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 11218 | -0.087 | -0.4864 | Yes |
| 75 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 11277 | -0.089 | -0.4859 | Yes |
| 76 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 11324 | -0.092 | -0.4843 | Yes |
| 77 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 11428 | -0.096 | -0.4868 | Yes |
| 78 | GGA2 | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 11432 | -0.097 | -0.4817 | Yes |
| 79 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 11480 | -0.099 | -0.4798 | Yes |
| 80 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 11650 | -0.107 | -0.4867 | Yes |
| 81 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 11671 | -0.108 | -0.4823 | Yes |
| 82 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 11708 | -0.110 | -0.4790 | Yes |
| 83 | LUM | LUM Entrez, Source | lumican | 11773 | -0.112 | -0.4777 | Yes |
| 84 | DPP3 | DPP3 Entrez, Source | dipeptidyl-peptidase 3 | 11822 | -0.115 | -0.4750 | Yes |
| 85 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11896 | -0.118 | -0.4740 | Yes |
| 86 | HEXB | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 11974 | -0.123 | -0.4730 | Yes |
| 87 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 12002 | -0.125 | -0.4682 | Yes |
| 88 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 12153 | -0.135 | -0.4721 | Yes |
| 89 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 12319 | -0.150 | -0.4763 | Yes |
| 90 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 12465 | -0.166 | -0.4782 | Yes |
| 91 | RAB34 | RAB34 Entrez, Source | RAB34, member RAS oncogene family | 12488 | -0.169 | -0.4706 | Yes |
| 92 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12541 | -0.177 | -0.4647 | Yes |
| 93 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 12556 | -0.179 | -0.4559 | Yes |
| 94 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 12661 | -0.197 | -0.4530 | Yes |
| 95 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12697 | -0.204 | -0.4444 | Yes |
| 96 | WFDC2 | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 12832 | -0.233 | -0.4417 | Yes |
| 97 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 12881 | -0.245 | -0.4319 | Yes |
| 98 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 13011 | -0.297 | -0.4253 | Yes |
| 99 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 13031 | -0.307 | -0.4099 | Yes |
| 100 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 13090 | -0.347 | -0.3952 | Yes |
| 101 | PROM1 | PROM1 Entrez, Source | prominin 1 | 13138 | -0.389 | -0.3773 | Yes |
| 102 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13160 | -0.412 | -0.3562 | Yes |
| 103 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 13193 | -0.458 | -0.3334 | Yes |
| 104 | TPBG | TPBG Entrez, Source | trophoblast glycoprotein | 13238 | -0.524 | -0.3079 | Yes |
| 105 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13271 | -0.644 | -0.2749 | Yes |
| 106 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 13273 | -0.645 | -0.2395 | Yes |
| 107 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13317 | -0.925 | -0.1919 | Yes |
| 108 | PKIB | PKIB Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 13324 | -0.997 | -0.1376 | Yes |
| 109 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 13335 | -1.251 | -0.0695 | Yes |
| 110 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13336 | -1.272 | 0.0005 | Yes |
