Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | ANDROGEN_GENES |
| Enrichment Score (ES) | 0.5248652 |
| Normalized Enrichment Score (NES) | 1.5915245 |
| Nominal p-value | 0.024229076 |
| FDR q-value | 0.07148774 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NR1I3 | NR1I3 Entrez, Source | nuclear receptor subfamily 1, group I, member 3 | 73 | 0.449 | 0.1698 | Yes |
| 2 | HSD11B1 | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 370 | 0.242 | 0.2420 | Yes |
| 3 | FKBP5 | FKBP5 Entrez, Source | FK506 binding protein 5 | 406 | 0.229 | 0.3287 | Yes |
| 4 | SRD5A2 | SRD5A2 Entrez, Source | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 681 | 0.176 | 0.3767 | Yes |
| 5 | AKR1B10 | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 1044 | 0.141 | 0.4044 | Yes |
| 6 | ARSE | ARSE Entrez, Source | arylsulfatase E (chondrodysplasia punctata 1) | 1768 | 0.102 | 0.3899 | Yes |
| 7 | CYP11B1 | CYP11B1 Entrez, Source | cytochrome P450, family 11, subfamily B, polypeptide 1 | 1789 | 0.102 | 0.4281 | Yes |
| 8 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 1859 | 0.099 | 0.4616 | Yes |
| 9 | RDH11 | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 2069 | 0.092 | 0.4817 | Yes |
| 10 | SRD5A1 | SRD5A1 Entrez, Source | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 2561 | 0.078 | 0.4753 | Yes |
| 11 | HSD17B2 | HSD17B2 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 2 | 2586 | 0.077 | 0.5035 | Yes |
| 12 | TMPRSS2 | TMPRSS2 Entrez, Source | transmembrane protease, serine 2 | 2687 | 0.074 | 0.5249 | Yes |
| 13 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 3384 | 0.058 | 0.4954 | No |
| 14 | FGF8 | FGF8 Entrez, Source | fibroblast growth factor 8 (androgen-induced) | 3478 | 0.056 | 0.5104 | No |
| 15 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 4542 | 0.037 | 0.4451 | No |
| 16 | RWDD1 | RWDD1 Entrez, Source | RWD domain containing 1 | 4687 | 0.034 | 0.4477 | No |
| 17 | HSD3B1 | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 4997 | 0.029 | 0.4359 | No |
| 18 | HSD17B8 | HSD17B8 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 8 | 5000 | 0.029 | 0.4471 | No |
| 19 | CRISP1 | CRISP1 Entrez, Source | cysteine-rich secretory protein 1 | 5133 | 0.027 | 0.4478 | No |
| 20 | NR3C1 | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5252 | 0.025 | 0.4488 | No |
| 21 | CRSP6 | CRSP6 Entrez, Source | cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa | 5759 | 0.018 | 0.4178 | No |
| 22 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 6596 | 0.005 | 0.3571 | No |
| 23 | NR3C2 | NR3C2 Entrez, Source | nuclear receptor subfamily 3, group C, member 2 | 6857 | 0.002 | 0.3383 | No |
| 24 | SHBG | SHBG Entrez, Source | sex hormone-binding globulin | 7230 | -0.003 | 0.3118 | No |
| 25 | SULT2A1 | SULT2A1 Entrez, Source | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 8105 | -0.016 | 0.2525 | No |
| 26 | PPAP2A | PPAP2A Entrez, Source | phosphatidic acid phosphatase type 2A | 8226 | -0.018 | 0.2507 | No |
| 27 | HSD17B3 | HSD17B3 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 3 | 8751 | -0.027 | 0.2220 | No |
| 28 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 9203 | -0.036 | 0.2021 | No |
| 29 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 10940 | -0.077 | 0.1016 | No |
| 30 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 11277 | -0.089 | 0.1113 | No |
| 31 | TGFB1I1 | TGFB1I1 Entrez, Source | transforming growth factor beta 1 induced transcript 1 | 11764 | -0.112 | 0.1185 | No |
