Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | ANTI_APOPTOSIS |
| Enrichment Score (ES) | -0.508822 |
| Normalized Enrichment Score (NES) | -1.7214533 |
| Nominal p-value | 0.0016806723 |
| FDR q-value | 0.055566836 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | BCL2A1 | BCL2A1 Entrez, Source | BCL2-related protein A1 | 67 | 0.459 | 0.0447 | No |
| 2 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 685 | 0.175 | 0.0172 | No |
| 3 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 717 | 0.171 | 0.0334 | No |
| 4 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 823 | 0.160 | 0.0429 | No |
| 5 | BCL2L10 | BCL2L10 Entrez, Source | BCL2-like 10 (apoptosis facilitator) | 975 | 0.147 | 0.0475 | No |
| 6 | SOCS2 | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 1150 | 0.133 | 0.0488 | No |
| 7 | IL2 | IL2 Entrez, Source | interleukin 2 | 1260 | 0.126 | 0.0543 | No |
| 8 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1520 | 0.112 | 0.0469 | No |
| 9 | BNIP1 | BNIP1 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 1 | 1865 | 0.099 | 0.0317 | No |
| 10 | CIAPIN1 | CIAPIN1 Entrez, Source | cytokine induced apoptosis inhibitor 1 | 2181 | 0.089 | 0.0176 | No |
| 11 | CD40LG | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 2885 | 0.069 | -0.0279 | No |
| 12 | IGF1R | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 3241 | 0.061 | -0.0480 | No |
| 13 | SFRP1 | SFRP1 Entrez, Source | secreted frizzled-related protein 1 | 3641 | 0.053 | -0.0723 | No |
| 14 | IL1A | IL1A Entrez, Source | interleukin 1, alpha | 3710 | 0.052 | -0.0719 | No |
| 15 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 3989 | 0.047 | -0.0878 | No |
| 16 | PRKCZ | PRKCZ Entrez, Source | protein kinase C, zeta | 4083 | 0.045 | -0.0899 | No |
| 17 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 4378 | 0.040 | -0.1078 | No |
| 18 | BAG4 | BAG4 Entrez, Source | BCL2-associated athanogene 4 | 4703 | 0.034 | -0.1285 | No |
| 19 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 5011 | 0.029 | -0.1485 | No |
| 20 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 5022 | 0.029 | -0.1461 | No |
| 21 | IL3 | IL3 Entrez, Source | interleukin 3 (colony-stimulating factor, multiple) | 5080 | 0.028 | -0.1474 | No |
| 22 | IL2RB | IL2RB Entrez, Source | interleukin 2 receptor, beta | 5178 | 0.027 | -0.1518 | No |
| 23 | GDNF | GDNF Entrez, Source | glial cell derived neurotrophic factor | 5229 | 0.026 | -0.1528 | No |
| 24 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 5266 | 0.025 | -0.1528 | No |
| 25 | DAD1 | DAD1 Entrez, Source | defender against cell death 1 | 5314 | 0.024 | -0.1537 | No |
| 26 | OPA1 | OPA1 Entrez, Source | optic atrophy 1 (autosomal dominant) | 5620 | 0.020 | -0.1745 | No |
| 27 | SON | SON Entrez, Source | SON DNA binding protein | 5809 | 0.017 | -0.1868 | No |
| 28 | BCL2L2 | BCL2L2 Entrez, Source | BCL2-like 2 | 6022 | 0.014 | -0.2013 | No |
| 29 | GLO1 | GLO1 Entrez, Source | glyoxalase I | 6031 | 0.014 | -0.2004 | No |
| 30 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 6099 | 0.013 | -0.2041 | No |
| 31 | TPT1 | TPT1 Entrez, Source | tumor protein, translationally-controlled 1 | 6352 | 0.009 | -0.2222 | No |
| 32 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6361 | 0.009 | -0.2218 | No |
| 33 | CRYAA | CRYAA Entrez, Source | crystallin, alpha A | 6379 | 0.008 | -0.2222 | No |
| 34 | TBX3 | TBX3 Entrez, Source | T-box 3 (ulnar mammary syndrome) | 6476 | 0.007 | -0.2287 | No |
| 35 | BECN1 | BECN1 Entrez, Source | beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) | 6675 | 0.004 | -0.2432 | No |
| 36 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6739 | 0.003 | -0.2476 | No |
| 37 | TAX1BP1 | TAX1BP1 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 6803 | 0.003 | -0.2521 | No |
| 38 | HDAC3 | HDAC3 Entrez, Source | histone deacetylase 3 | 6844 | 0.002 | -0.2548 | No |
| 39 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 7074 | -0.001 | -0.2720 | No |
| 40 | HIPK3 | HIPK3 Entrez, Source | homeodomain interacting protein kinase 3 | 7248 | -0.004 | -0.2846 | No |
| 41 | PSEN1 | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 7574 | -0.009 | -0.3082 | No |
| 42 | CD28 | CD28 Entrez, Source | CD28 molecule | 7763 | -0.011 | -0.3211 | No |
| 43 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 7875 | -0.013 | -0.3280 | No |
| 44 | BFAR | BFAR Entrez, Source | bifunctional apoptosis regulator | 8254 | -0.019 | -0.3545 | No |
| 45 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 8508 | -0.023 | -0.3710 | No |
| 46 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 8656 | -0.026 | -0.3793 | No |
| 47 | BRE | BRE Entrez, Source | brain and reproductive organ-expressed (TNFRSF1A modulator) | 8672 | -0.026 | -0.3777 | No |
| 48 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 8887 | -0.030 | -0.3906 | No |
| 49 | PRDX2 | PRDX2 Entrez, Source | peroxiredoxin 2 | 9109 | -0.034 | -0.4035 | No |
| 50 | MCL1 | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 9244 | -0.037 | -0.4096 | No |
| 51 | IER3 | IER3 Entrez, Source | immediate early response 3 | 9311 | -0.038 | -0.4105 | No |
| 52 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 9335 | -0.038 | -0.4081 | No |
| 53 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 9372 | -0.039 | -0.4065 | No |
| 54 | RTKN | RTKN Entrez, Source | rhotekin | 9437 | -0.040 | -0.4070 | No |
| 55 | BAX | BAX Entrez, Source | BCL2-associated X protein | 9773 | -0.047 | -0.4271 | No |
| 56 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 10137 | -0.055 | -0.4485 | No |
| 57 | TXNDC1 | TXNDC1 Entrez, Source | thioredoxin domain containing 1 | 10781 | -0.072 | -0.4892 | No |
| 58 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 10828 | -0.073 | -0.4847 | No |
| 59 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 10949 | -0.077 | -0.4854 | No |
| 60 | SH3GLB1 | SH3GLB1 Entrez, Source | SH3-domain GRB2-like endophilin B1 | 10950 | -0.077 | -0.4771 | No |
| 61 | GPX1 | GPX1 Entrez, Source | glutathione peroxidase 1 | 11279 | -0.089 | -0.4921 | No |
| 62 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 11360 | -0.093 | -0.4880 | No |
| 63 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 11637 | -0.106 | -0.4973 | Yes |
| 64 | NOL3 | NOL3 Entrez, Source | nucleolar protein 3 (apoptosis repressor with CARD domain) | 11695 | -0.109 | -0.4898 | Yes |
| 65 | YWHAZ | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 11724 | -0.110 | -0.4800 | Yes |
| 66 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 11988 | -0.124 | -0.4863 | Yes |
| 67 | ANXA4 | ANXA4 Entrez, Source | annexin A4 | 12040 | -0.127 | -0.4764 | Yes |
| 68 | PROK2 | PROK2 Entrez, Source | prokineticin 2 | 12439 | -0.162 | -0.4888 | Yes |
| 69 | SPHK1 | SPHK1 Entrez, Source | sphingosine kinase 1 | 12507 | -0.172 | -0.4752 | Yes |
| 70 | CDH13 | CDH13 Entrez, Source | cadherin 13, H-cadherin (heart) | 12630 | -0.190 | -0.4638 | Yes |
| 71 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 12656 | -0.196 | -0.4445 | Yes |
| 72 | ANXA5 | ANXA5 Entrez, Source | annexin A5 | 12706 | -0.206 | -0.4259 | Yes |
| 73 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12779 | -0.218 | -0.4077 | Yes |
| 74 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 12847 | -0.236 | -0.3871 | Yes |
| 75 | DDAH2 | DDAH2 Entrez, Source | dimethylarginine dimethylaminohydrolase 2 | 12900 | -0.253 | -0.3636 | Yes |
| 76 | CRYAB | CRYAB Entrez, Source | crystallin, alpha B | 13153 | -0.404 | -0.3388 | Yes |
| 77 | RTN4 | RTN4 Entrez, Source | reticulon 4 | 13219 | -0.495 | -0.2900 | Yes |
| 78 | PEA15 | PEA15 Entrez, Source | phosphoprotein enriched in astrocytes 15 | 13253 | -0.561 | -0.2317 | Yes |
| 79 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13317 | -0.925 | -0.1361 | Yes |
| 80 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13336 | -1.272 | 0.0005 | Yes |
