Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | BREAST_CANCER_ESTROGEN_SIGNALING |
| Enrichment Score (ES) | -0.52146643 |
| Normalized Enrichment Score (NES) | -1.7355082 |
| Nominal p-value | 0.006688963 |
| FDR q-value | 0.051564634 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IL6R | IL6R Entrez, Source | interleukin 6 receptor | 264 | 0.281 | 0.0152 | No |
| 2 | AZGP1 | AZGP1 Entrez, Source | alpha-2-glycoprotein 1, zinc | 293 | 0.268 | 0.0466 | No |
| 3 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 473 | 0.209 | 0.0592 | No |
| 4 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 901 | 0.153 | 0.0461 | No |
| 5 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 986 | 0.146 | 0.0581 | No |
| 6 | C3 | C3 Entrez, Source | complement component 3 | 1475 | 0.114 | 0.0356 | No |
| 7 | DLC1 | DLC1 Entrez, Source | deleted in liver cancer 1 | 1483 | 0.114 | 0.0493 | No |
| 8 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 1781 | 0.102 | 0.0397 | No |
| 9 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 2436 | 0.082 | 0.0006 | No |
| 10 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 2560 | 0.078 | 0.0011 | No |
| 11 | NME1 | NME1 Entrez, Source | non-metastatic cells 1, protein (NM23A) expressed in | 2764 | 0.072 | -0.0052 | No |
| 12 | GNAS | GNAS Entrez, Source | GNAS complex locus | 2815 | 0.071 | -0.0001 | No |
| 13 | NGFR | NGFR Entrez, Source | nerve growth factor receptor (TNFR superfamily, member 16) | 3208 | 0.062 | -0.0219 | No |
| 14 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 3721 | 0.052 | -0.0540 | No |
| 15 | IL6ST | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 3732 | 0.051 | -0.0484 | No |
| 16 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3781 | 0.050 | -0.0458 | No |
| 17 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 4079 | 0.045 | -0.0625 | No |
| 18 | SLC7A5 | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 4470 | 0.038 | -0.0872 | No |
| 19 | ESR2 | ESR2 Entrez, Source | estrogen receptor 2 (ER beta) | 4553 | 0.037 | -0.0887 | No |
| 20 | TFF3 | TFF3 Entrez, Source | trefoil factor 3 (intestinal) | 4555 | 0.037 | -0.0842 | No |
| 21 | MUC1 | MUC1 Entrez, Source | mucin 1, cell surface associated | 5222 | 0.026 | -0.1311 | No |
| 22 | CDH1 | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 5315 | 0.024 | -0.1350 | No |
| 23 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5720 | 0.018 | -0.1631 | No |
| 24 | BCL2L2 | BCL2L2 Entrez, Source | BCL2-like 2 | 6022 | 0.014 | -0.1841 | No |
| 25 | NFYB | NFYB Entrez, Source | nuclear transcription factor Y, beta | 6139 | 0.012 | -0.1913 | No |
| 26 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.1912 | No |
| 27 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 6332 | 0.009 | -0.2031 | No |
| 28 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 6596 | 0.005 | -0.2222 | No |
| 29 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 6709 | 0.004 | -0.2302 | No |
| 30 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | -0.2332 | No |
| 31 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 6773 | 0.003 | -0.2341 | No |
| 32 | TFF1 | TFF1 Entrez, Source | trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) | 6791 | 0.003 | -0.2351 | No |
| 33 | THBS4 | THBS4 Entrez, Source | thrombospondin 4 | 6884 | 0.002 | -0.2418 | No |
| 34 | RPL27 | RPL27 Entrez, Source | ribosomal protein L27 | 6890 | 0.001 | -0.2420 | No |
| 35 | SCGB1D2 | SCGB1D2 Entrez, Source | secretoglobin, family 1D, member 2 | 7177 | -0.003 | -0.2632 | No |
| 36 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 7239 | -0.004 | -0.2674 | No |
| 37 | RPL13A | RPL13A Entrez, Source | ribosomal protein L13a | 7446 | -0.007 | -0.2821 | No |
| 38 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 7492 | -0.007 | -0.2845 | No |
| 39 | PGR | PGR Entrez, Source | progesterone receptor | 7642 | -0.010 | -0.2946 | No |
| 40 | PPIA | PPIA Entrez, Source | peptidylprolyl isomerase A (cyclophilin A) | 8225 | -0.018 | -0.3361 | No |
| 41 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 8231 | -0.019 | -0.3342 | No |
| 42 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8312 | -0.020 | -0.3377 | No |
| 43 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.3357 | No |
| 44 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 8384 | -0.021 | -0.3378 | No |
| 45 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 8508 | -0.023 | -0.3442 | No |
| 46 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 8727 | -0.027 | -0.3573 | No |
| 47 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 8887 | -0.030 | -0.3655 | No |
| 48 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 9097 | -0.034 | -0.3770 | No |
| 49 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9129 | -0.035 | -0.3751 | No |
| 50 | IL2RA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 9245 | -0.037 | -0.3791 | No |
| 51 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 9769 | -0.047 | -0.4127 | No |
| 52 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 9961 | -0.051 | -0.4206 | No |
| 53 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 10940 | -0.077 | -0.4848 | No |
| 54 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 11428 | -0.096 | -0.5094 | Yes |
| 55 | ACTB | ACTB Entrez, Source | actin, beta | 11552 | -0.102 | -0.5060 | Yes |
| 56 | JUN | JUN Entrez, Source | jun oncogene | 11756 | -0.111 | -0.5074 | Yes |
| 57 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11886 | -0.118 | -0.5023 | Yes |
| 58 | CTSB | CTSB Entrez, Source | cathepsin B | 11943 | -0.121 | -0.4914 | Yes |
| 59 | CLU | CLU Entrez, Source | clusterin | 12046 | -0.128 | -0.4831 | Yes |
| 60 | KLF5 | KLF5 Entrez, Source | Kruppel-like factor 5 (intestinal) | 12107 | -0.132 | -0.4711 | Yes |
| 61 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 12233 | -0.142 | -0.4628 | Yes |
| 62 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 12348 | -0.153 | -0.4523 | Yes |
| 63 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 12355 | -0.153 | -0.4336 | Yes |
| 64 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12398 | -0.157 | -0.4171 | Yes |
| 65 | FGF1 | FGF1 Entrez, Source | fibroblast growth factor 1 (acidic) | 12527 | -0.175 | -0.4048 | Yes |
| 66 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 12546 | -0.178 | -0.3839 | Yes |
| 67 | FOSL1 | FOSL1 Entrez, Source | FOS-like antigen 1 | 12828 | -0.232 | -0.3762 | Yes |
| 68 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 12847 | -0.236 | -0.3480 | Yes |
| 69 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12855 | -0.239 | -0.3187 | Yes |
| 70 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13085 | -0.343 | -0.2932 | Yes |
| 71 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13125 | -0.378 | -0.2489 | Yes |
| 72 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 13174 | -0.431 | -0.1986 | Yes |
| 73 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13308 | -0.800 | -0.1087 | Yes |
| 74 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13314 | -0.890 | 0.0021 | Yes |
