Details for gene set CARBOXYLIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos
Phenotype	class.cls#double_gel_72h_versus_single_gel_72h_repos
Upregulated in class	double_gel_72h
GeneSet	CARBOXYLIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.63622004
Normalized Enrichment Score (NES)	2.5111248
Nominal p-value	0.0
FDR q-value	0.0
FWER p-Value	0.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	9	0.779	0.0360	Yes
2	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	13	0.740	0.0706	Yes
3	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	15	0.731	0.1049	Yes
4	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	33	0.554	0.1298	Yes
5	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	54	0.488	0.1512	Yes
6	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	58	0.484	0.1738	Yes
7	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	95	0.419	0.1908	Yes
8	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	110	0.403	0.2087	Yes
9	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	126	0.385	0.2257	Yes
10	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	128	0.384	0.2436	Yes
11	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	140	0.368	0.2601	Yes
12	ARG1	ARG1 Entrez, Source	arginase, liver	145	0.358	0.2767	Yes
13	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	182	0.324	0.2892	Yes
14	ASL	ASL Entrez, Source	argininosuccinate lyase	183	0.323	0.3045	Yes
15	ACLY	ACLY Entrez, Source	ATP citrate lyase	212	0.305	0.3167	Yes
16	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	219	0.299	0.3303	Yes
17	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	230	0.293	0.3434	Yes
18	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	242	0.289	0.3561	Yes
19	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	246	0.288	0.3695	Yes
20	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	284	0.273	0.3795	Yes
21	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	295	0.267	0.3913	Yes
22	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	315	0.262	0.4022	Yes
23	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	320	0.260	0.4142	Yes
24	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	341	0.252	0.4245	Yes
25	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	378	0.240	0.4331	Yes
26	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	428	0.222	0.4398	Yes
27	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	444	0.218	0.4489	Yes
28	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	445	0.217	0.4591	Yes
29	SCLY	SCLY Entrez, Source	selenocysteine lyase	454	0.214	0.4686	Yes
30	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	465	0.211	0.4778	Yes
31	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	482	0.207	0.4864	Yes
32	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	536	0.195	0.4915	Yes
33	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	553	0.192	0.4993	Yes
34	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	595	0.186	0.5050	Yes
35	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	597	0.186	0.5137	Yes
36	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	599	0.186	0.5224	Yes
37	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	612	0.184	0.5302	Yes
38	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	619	0.184	0.5384	Yes
39	PAH	PAH Entrez, Source	phenylalanine hydroxylase	628	0.182	0.5464	Yes
40	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	633	0.182	0.5546	Yes
41	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	651	0.179	0.5618	Yes
42	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	662	0.178	0.5694	Yes
43	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	776	0.165	0.5686	Yes
44	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	800	0.163	0.5745	Yes
45	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	816	0.161	0.5809	Yes
46	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	823	0.160	0.5880	Yes
47	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	868	0.156	0.5920	Yes
48	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	933	0.150	0.5943	Yes
49	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	951	0.149	0.6000	Yes
50	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	984	0.146	0.6045	Yes
51	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	1046	0.140	0.6064	Yes
52	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	1151	0.133	0.6049	Yes
53	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	1252	0.127	0.6032	Yes
54	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	1387	0.119	0.5987	Yes
55	AMT	AMT Entrez, Source	aminomethyltransferase	1397	0.119	0.6036	Yes
56	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	1471	0.115	0.6035	Yes
57	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	1480	0.114	0.6083	Yes
58	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	1494	0.114	0.6126	Yes
59	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	1495	0.114	0.6180	Yes
60	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	1524	0.112	0.6211	Yes
61	HDC	HDC Entrez, Source	histidine decarboxylase	1527	0.112	0.6263	Yes
62	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	1560	0.110	0.6290	Yes
63	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	1612	0.108	0.6303	Yes
64	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	1648	0.107	0.6326	Yes
65	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	1678	0.106	0.6354	Yes
66	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	1733	0.104	0.6362	Yes
67	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	1840	0.100	0.6329	No
68	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	1859	0.099	0.6362	No
69	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	1926	0.096	0.6357	No
70	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	2100	0.091	0.6269	No
71	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	2159	0.089	0.6267	No
72	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	2259	0.086	0.6233	No
73	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	2407	0.082	0.6160	No
74	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	2496	0.080	0.6131	No
75	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	2598	0.076	0.6091	No
76	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	2648	0.075	0.6089	No
77	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	3046	0.066	0.5820	No
78	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	3058	0.065	0.5842	No
79	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	3063	0.065	0.5870	No
80	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	3136	0.064	0.5845	No
81	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	3398	0.058	0.5675	No
82	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	3517	0.056	0.5612	No
83	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	3642	0.053	0.5543	No
84	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	3715	0.052	0.5512	No
85	GSS	GSS Entrez, Source	glutathione synthetase	4011	0.046	0.5311	No
86	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	4028	0.046	0.5320	No
87	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	4162	0.044	0.5240	No
88	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	4275	0.042	0.5175	No
89	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	4299	0.041	0.5177	No
90	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	4326	0.041	0.5177	No
91	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	4383	0.040	0.5153	No
92	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	4470	0.038	0.5106	No
93	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	4675	0.035	0.4968	No
94	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	4803	0.032	0.4887	No
95	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	4887	0.031	0.4839	No
96	ARPP-19	ARPP-19 Entrez, Source	-	5020	0.029	0.4752	No
97	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	5087	0.028	0.4715	No
98	PTGES	PTGES Entrez, Source	prostaglandin E synthase	5602	0.020	0.4336	No
99	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	5859	0.016	0.4150	No
100	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	5886	0.016	0.4138	No
101	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	5916	0.015	0.4123	No
102	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	6040	0.014	0.4036	No
103	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	6478	0.007	0.3709	No
104	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	6489	0.007	0.3704	No
105	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	6738	0.003	0.3518	No
106	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	7266	-0.004	0.3121	No
107	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	7269	-0.004	0.3122	No
108	SLC3A1	SLC3A1 Entrez, Source	1	7374	-0.006	0.3045	No
109	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	8036	-0.015	0.2552	No
110	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8089	-0.016	0.2521	No
111	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	8292	-0.020	0.2377	No
112	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	8460	-0.022	0.2261	No
113	SDS	SDS Entrez, Source	serine dehydratase	8683	-0.026	0.2105	No
114	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	9012	-0.032	0.1872	No
115	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	9114	-0.034	0.1812	No
116	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	9209	-0.036	0.1758	No
117	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	9316	-0.038	0.1696	No
118	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	9816	-0.048	0.1341	No
119	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	10430	-0.062	0.0906	No
120	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	10797	-0.072	0.0663	No
121	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	10801	-0.073	0.0695	No
122	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	11324	-0.092	0.0343	No
123	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	11580	-0.103	0.0199	No
124	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	11691	-0.109	0.0166	No
125	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	12626	-0.189	-0.0452	No
126	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	12900	-0.253	-0.0539	No
127	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	12939	-0.266	-0.0443	No
128	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	13097	-0.354	-0.0395	No
129	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	13118	-0.367	-0.0237	No
130	SMS	SMS Entrez, Source	spermine synthase	13163	-0.420	-0.0073	No
131	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	13181	-0.442	0.0122	No