Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | CATABOLIC_PROCESS |
| Enrichment Score (ES) | 0.42819768 |
| Normalized Enrichment Score (NES) | 1.7049608 |
| Nominal p-value | 0.002754821 |
| FDR q-value | 0.03547139 |
| FWER p-Value | 0.998 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HACL1 | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 54 | 0.488 | 0.0324 | Yes |
| 2 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 110 | 0.403 | 0.0584 | Yes |
| 3 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 126 | 0.385 | 0.0860 | Yes |
| 4 | MDM4 | MDM4 Entrez, Source | Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) | 141 | 0.366 | 0.1123 | Yes |
| 5 | ARG1 | ARG1 Entrez, Source | arginase, liver | 145 | 0.358 | 0.1389 | Yes |
| 6 | ASL | ASL Entrez, Source | argininosuccinate lyase | 183 | 0.323 | 0.1603 | Yes |
| 7 | ACLY | ACLY Entrez, Source | ATP citrate lyase | 212 | 0.305 | 0.1810 | Yes |
| 8 | FAH | FAH Entrez, Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 219 | 0.299 | 0.2029 | Yes |
| 9 | PFKFB1 | PFKFB1 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 230 | 0.293 | 0.2241 | Yes |
| 10 | MIOX | MIOX Entrez, Source | myo-inositol oxygenase | 234 | 0.291 | 0.2456 | Yes |
| 11 | ZFP36 | ZFP36 Entrez, Source | zinc finger protein 36, C3H type, homolog (mouse) | 368 | 0.242 | 0.2537 | Yes |
| 12 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 388 | 0.235 | 0.2698 | Yes |
| 13 | ALDH1L1 | ALDH1L1 Entrez, Source | aldehyde dehydrogenase 1 family, member L1 | 465 | 0.211 | 0.2799 | Yes |
| 14 | ACADVL | ACADVL Entrez, Source | acyl-Coenzyme A dehydrogenase, very long chain | 482 | 0.207 | 0.2942 | Yes |
| 15 | HAO2 | HAO2 Entrez, Source | hydroxyacid oxidase 2 (long chain) | 536 | 0.195 | 0.3047 | Yes |
| 16 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 563 | 0.190 | 0.3170 | Yes |
| 17 | ALDH5A1 | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 612 | 0.184 | 0.3271 | Yes |
| 18 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 633 | 0.182 | 0.3392 | Yes |
| 19 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 651 | 0.179 | 0.3513 | Yes |
| 20 | BCKDHA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 662 | 0.178 | 0.3639 | Yes |
| 21 | GCSH | GCSH Entrez, Source | glycine cleavage system protein H (aminomethyl carrier) | 816 | 0.161 | 0.3644 | Yes |
| 22 | PRSS2 | PRSS2 Entrez, Source | protease, serine, 2 (trypsin 2) | 818 | 0.161 | 0.3763 | Yes |
| 23 | BCKDK | BCKDK Entrez, Source | branched chain ketoacid dehydrogenase kinase | 868 | 0.156 | 0.3842 | Yes |
| 24 | DHPS | DHPS Entrez, Source | deoxyhypusine synthase | 996 | 0.145 | 0.3855 | Yes |
| 25 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 1007 | 0.144 | 0.3955 | Yes |
| 26 | CPT1A | CPT1A Entrez, Source | carnitine palmitoyltransferase 1A (liver) | 1046 | 0.140 | 0.4031 | Yes |
| 27 | SMPD3 | SMPD3 Entrez, Source | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | 1232 | 0.128 | 0.3986 | Yes |
| 28 | PPARA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 1252 | 0.127 | 0.4067 | Yes |
| 29 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 1307 | 0.124 | 0.4118 | Yes |
| 30 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 1387 | 0.119 | 0.4148 | Yes |
| 31 | AMT | AMT Entrez, Source | aminomethyltransferase | 1397 | 0.119 | 0.4230 | Yes |
| 32 | ASRGL1 | ASRGL1 Entrez, Source | asparaginase like 1 | 1612 | 0.108 | 0.4149 | Yes |
| 33 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 1733 | 0.104 | 0.4136 | Yes |
| 34 | PARK2 | PARK2 Entrez, Source | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 1812 | 0.101 | 0.4152 | Yes |
| 35 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 1859 | 0.099 | 0.4191 | Yes |
| 36 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 1864 | 0.099 | 0.4262 | Yes |
| 37 | APOA4 | APOA4 Entrez, Source | apolipoprotein A-IV | 1934 | 0.096 | 0.4282 | Yes |
| 38 | SYVN1 | SYVN1 Entrez, Source | synovial apoptosis inhibitor 1, synoviolin | 2057 | 0.092 | 0.4259 | No |
| 39 | FBXO7 | FBXO7 Entrez, Source | F-box protein 7 | 2304 | 0.085 | 0.4136 | No |
| 40 | CPT1B | CPT1B Entrez, Source | carnitine palmitoyltransferase 1B (muscle) | 2496 | 0.080 | 0.4051 | No |
| 41 | SDHD | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 2529 | 0.079 | 0.4086 | No |
| 42 | SDHA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 2780 | 0.072 | 0.3950 | No |
| 43 | ABCE1 | ABCE1 Entrez, Source | ATP-binding cassette, sub-family E (OABP), member 1 | 2923 | 0.068 | 0.3894 | No |
| 44 | UBE2N | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 2977 | 0.067 | 0.3904 | No |
| 45 | ACO2 | ACO2 Entrez, Source | aconitase 2, mitochondrial | 3136 | 0.064 | 0.3832 | No |
| 46 | MCCC2 | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 3517 | 0.056 | 0.3586 | No |
| 47 | UBE2V2 | UBE2V2 Entrez, Source | ubiquitin-conjugating enzyme E2 variant 2 | 3602 | 0.054 | 0.3562 | No |
| 48 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 3706 | 0.052 | 0.3523 | No |
| 49 | UFD1L | UFD1L Entrez, Source | ubiquitin fusion degradation 1 like (yeast) | 3750 | 0.051 | 0.3528 | No |
| 50 | UBE4A | UBE4A Entrez, Source | ubiquitination factor E4A (UFD2 homolog, yeast) | 3826 | 0.049 | 0.3509 | No |
| 51 | MPST | MPST Entrez, Source | mercaptopyruvate sulfurtransferase | 3883 | 0.049 | 0.3503 | No |
| 52 | FBXO22 | FBXO22 Entrez, Source | F-box protein 22 | 3983 | 0.047 | 0.3463 | No |
| 53 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 4162 | 0.044 | 0.3360 | No |
| 54 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 4299 | 0.041 | 0.3288 | No |
| 55 | BLVRA | BLVRA Entrez, Source | biliverdin reductase A | 4380 | 0.040 | 0.3258 | No |
| 56 | HPD | HPD Entrez, Source | 4-hydroxyphenylpyruvate dioxygenase | 4383 | 0.040 | 0.3286 | No |
| 57 | BTRC | BTRC Entrez, Source | beta-transducin repeat containing | 4551 | 0.037 | 0.3187 | No |
| 58 | HADHB | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 4675 | 0.035 | 0.3120 | No |
| 59 | GLUD1 | GLUD1 Entrez, Source | glutamate dehydrogenase 1 | 5087 | 0.028 | 0.2830 | No |
| 60 | PSMC5 | PSMC5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 5269 | 0.025 | 0.2711 | No |
| 61 | EGLN2 | EGLN2 Entrez, Source | egl nine homolog 2 (C. elegans) | 5283 | 0.025 | 0.2720 | No |
| 62 | CES2 | CES2 Entrez, Source | carboxylesterase 2 (intestine, liver) | 5418 | 0.023 | 0.2636 | No |
| 63 | COLQ | COLQ Entrez, Source | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 5644 | 0.020 | 0.2480 | No |
| 64 | SDHC | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 5789 | 0.018 | 0.2385 | No |
| 65 | APOA5 | APOA5 Entrez, Source | apolipoprotein A-V | 5815 | 0.017 | 0.2378 | No |
| 66 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 5859 | 0.016 | 0.2358 | No |
| 67 | ACADS | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 5886 | 0.016 | 0.2350 | No |
| 68 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 5916 | 0.015 | 0.2340 | No |
| 69 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 5927 | 0.015 | 0.2344 | No |
| 70 | SQSTM1 | SQSTM1 Entrez, Source | sequestosome 1 | 6130 | 0.012 | 0.2200 | No |
| 71 | SIAH2 | SIAH2 Entrez, Source | seven in absentia homolog 2 (Drosophila) | 6351 | 0.009 | 0.2040 | No |
| 72 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6707 | 0.004 | 0.1774 | No |
| 73 | GSPT1 | GSPT1 Entrez, Source | G1 to S phase transition 1 | 6717 | 0.004 | 0.1770 | No |
| 74 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | 0.1744 | No |
| 75 | PRDX6 | PRDX6 Entrez, Source | peroxiredoxin 6 | 6768 | 0.003 | 0.1738 | No |
| 76 | TSG101 | TSG101 Entrez, Source | tumor susceptibility gene 101 | 6868 | 0.002 | 0.1664 | No |
| 77 | GAPDHS | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 6929 | 0.001 | 0.1619 | No |
| 78 | NUDT3 | NUDT3 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 6981 | 0.000 | 0.1581 | No |
| 79 | NUDT5 | NUDT5 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 5 | 7094 | -0.002 | 0.1497 | No |
| 80 | PABPC4 | PABPC4 Entrez, Source | poly(A) binding protein, cytoplasmic 4 (inducible form) | 7148 | -0.002 | 0.1459 | No |
| 81 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 7269 | -0.004 | 0.1371 | No |
| 82 | USP33 | USP33 Entrez, Source | ubiquitin specific peptidase 33 | 7270 | -0.004 | 0.1374 | No |
| 83 | NEU3 | NEU3 Entrez, Source | sialidase 3 (membrane sialidase) | 7444 | -0.007 | 0.1248 | No |
| 84 | UBE2A | UBE2A Entrez, Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 7458 | -0.007 | 0.1243 | No |
| 85 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 7556 | -0.008 | 0.1176 | No |
| 86 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 7875 | -0.013 | 0.0945 | No |
| 87 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7883 | -0.013 | 0.0950 | No |
| 88 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 8101 | -0.016 | 0.0798 | No |
| 89 | UBE2B | UBE2B Entrez, Source | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 8205 | -0.018 | 0.0733 | No |
| 90 | NPLOC4 | NPLOC4 Entrez, Source | nuclear protein localization 4 homolog (S. cerevisiae) | 8271 | -0.019 | 0.0699 | No |
| 91 | RNASE6 | RNASE6 Entrez, Source | ribonuclease, RNase A family, k6 | 8373 | -0.021 | 0.0638 | No |
| 92 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 8392 | -0.021 | 0.0640 | No |
| 93 | UBE2G1 | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 8500 | -0.023 | 0.0577 | No |
| 94 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 8548 | -0.024 | 0.0559 | No |
| 95 | NEDD8 | NEDD8 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 8 | 8682 | -0.026 | 0.0478 | No |
| 96 | UBB | UBB Entrez, Source | ubiquitin B | 8839 | -0.029 | 0.0381 | No |
| 97 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 8916 | -0.030 | 0.0346 | No |
| 98 | INDO | INDO Entrez, Source | indoleamine-pyrrole 2,3 dioxygenase | 9012 | -0.032 | 0.0299 | No |
| 99 | RNASEH1 | RNASEH1 Entrez, Source | ribonuclease H1 | 9069 | -0.033 | 0.0281 | No |
| 100 | VCP | VCP Entrez, Source | valosin-containing protein | 9139 | -0.035 | 0.0255 | No |
| 101 | TREH | TREH Entrez, Source | trehalase (brush-border membrane glycoprotein) | 9359 | -0.039 | 0.0118 | No |
| 102 | PPT1 | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 9419 | -0.040 | 0.0104 | No |
| 103 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 9513 | -0.042 | 0.0065 | No |
| 104 | ARIH1 | ARIH1 Entrez, Source | ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) | 9532 | -0.042 | 0.0083 | No |
| 105 | RNASEH2A | RNASEH2A Entrez, Source | ribonuclease H2, subunit A | 9648 | -0.045 | 0.0029 | No |
| 106 | BAX | BAX Entrez, Source | BCL2-associated X protein | 9773 | -0.047 | -0.0030 | No |
| 107 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 9779 | -0.047 | 0.0002 | No |
| 108 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 9802 | -0.048 | 0.0021 | No |
| 109 | HGS | HGS Entrez, Source | hepatocyte growth factor-regulated tyrosine kinase substrate | 10367 | -0.061 | -0.0360 | No |
| 110 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 10467 | -0.063 | -0.0388 | No |
| 111 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 10523 | -0.065 | -0.0381 | No |
| 112 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 10756 | -0.071 | -0.0503 | No |
| 113 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 10797 | -0.072 | -0.0479 | No |
| 114 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 10808 | -0.073 | -0.0433 | No |
| 115 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 10999 | -0.079 | -0.0518 | No |
| 116 | GAA | GAA Entrez, Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 11007 | -0.079 | -0.0464 | No |
| 117 | GUSB | GUSB Entrez, Source | glucuronidase, beta | 11065 | -0.081 | -0.0447 | No |
| 118 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 11277 | -0.089 | -0.0540 | No |
| 119 | ANAPC2 | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 11844 | -0.116 | -0.0881 | No |
| 120 | HK1 | HK1 Entrez, Source | hexokinase 1 | 12060 | -0.129 | -0.0948 | No |
| 121 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 12256 | -0.144 | -0.0988 | No |
| 122 | TPP1 | TPP1 Entrez, Source | tripeptidyl peptidase I | 12262 | -0.145 | -0.0883 | No |
| 123 | PYGB | PYGB Entrez, Source | phosphorylase, glycogen; brain | 12718 | -0.208 | -0.1072 | No |
| 124 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 12804 | -0.226 | -0.0967 | No |
| 125 | DDAH2 | DDAH2 Entrez, Source | dimethylarginine dimethylaminohydrolase 2 | 12900 | -0.253 | -0.0850 | No |
| 126 | LYPLA3 | LYPLA3 Entrez, Source | lysophospholipase 3 (lysosomal phospholipase A2) | 12939 | -0.266 | -0.0680 | No |
| 127 | AMPD3 | AMPD3 Entrez, Source | adenosine monophosphate deaminase (isoform E) | 12958 | -0.275 | -0.0488 | No |
| 128 | HNRPD | HNRPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 13048 | -0.319 | -0.0316 | No |
| 129 | GPX3 | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 13095 | -0.352 | -0.0088 | No |
| 130 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 13118 | -0.367 | 0.0170 | No |
