Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_72h_versus_single_gel_72h.class.cls
#double_gel_72h_versus_single_gel_72h_repos
Phenotypeclass.cls#double_gel_72h_versus_single_gel_72h_repos
Upregulated in classdouble_gel_72h
GeneSetCELLULAR_BIOSYNTHETIC_PROCESS
Enrichment Score (ES)0.38698712
Normalized Enrichment Score (NES)1.5956475
Nominal p-value0.0
FDR q-value0.07045351
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: CELLULAR_BIOSYNTHETIC_PROCESS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1BBOX1BBOX1
Entrez,  Source
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1130.7400.0441Yes
2APOA2APOA2
Entrez,  Source
apolipoprotein A-II220.6010.0800Yes
3LTBLTB
Entrez,  Source
lymphotoxin beta (TNF superfamily, member 3)350.5390.1119Yes
4CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I580.4840.1397Yes
5GCKGCK
Entrez,  Source
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)1400.3680.1559Yes
6FADS2FADS2
Entrez,  Source
fatty acid desaturase 21820.3240.1726Yes
7PFKFB1PFKFB1
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 12300.2930.1868Yes
8GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)2430.2890.2035Yes
9ACN9ACN9
Entrez,  Source
ACN9 homolog (S. cerevisiae)2840.2730.2171Yes
10GAMTGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase2950.2670.2326Yes
11MOCS2MOCS2
Entrez,  Source
molybdenum cofactor synthesis 23520.2480.2434Yes
12ABCA1ABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 13550.2480.2584Yes
13SLC25A10SLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 103780.2400.2713Yes
14ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 14190.2240.2819Yes
15DGAT2DGAT2
Entrez,  Source
diacylglycerol O-acyltransferase homolog 2 (mouse)5030.2010.2879Yes
16HRSP12HRSP12
Entrez,  Source
heat-responsive protein 125190.1980.2988Yes
17SIGIRRSIGIRR
Entrez,  Source
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain5440.1940.3088Yes
18GCHFRGCHFR
Entrez,  Source
GTP cyclohydrolase I feedback regulator5580.1910.3194Yes
19PAHPAH
Entrez,  Source
phenylalanine hydroxylase6280.1820.3252Yes
20DMDDMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)6860.1750.3316Yes
21ME1ME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic8000.1630.3329Yes
22GCLCGCLC
Entrez,  Source
glutamate-cysteine ligase, catalytic subunit8230.1600.3410Yes
23ALADALAD
Entrez,  Source
aminolevulinate, delta-, dehydratase8260.1600.3506Yes
24EIF1EIF1
Entrez,  Source
eukaryotic translation initiation factor 18760.1550.3563Yes
25UGDHUGDH
Entrez,  Source
UDP-glucose dehydrogenase9510.1490.3597Yes
26RPL39RPL39
Entrez,  Source
ribosomal protein L399600.1480.3681Yes
27YARSYARS
Entrez,  Source
tyrosyl-tRNA synthetase9840.1460.3753Yes
28DHPSDHPS
Entrez,  Source
deoxyhypusine synthase9960.1450.3833Yes
29UCN2UCN2
Entrez,  Source
urocortin 210970.1370.3840Yes
30INHAINHA
Entrez,  Source
inhibin, alpha12700.1260.3786Yes
31COQ3COQ3
Entrez,  Source
coenzyme Q3 homolog, methyltransferase (S. cerevisiae)14060.1180.3756Yes
32FADS1FADS1
Entrez,  Source
fatty acid desaturase 114950.1140.3758Yes
33CD74CD74
Entrez,  Source
CD74 molecule, major histocompatibility complex, class II invariant chain15240.1120.3805Yes
34NQO1NQO1
Entrez,  Source
NAD(P)H dehydrogenase, quinone 115320.1120.3868Yes
35MTIF2MTIF2
Entrez,  Source
mitochondrial translational initiation factor 217970.1010.3728Yes
36GCLMGCLM
Entrez,  Source
glutamate-cysteine ligase, modifier subunit18400.1000.3757Yes
37AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)18590.0990.3804Yes
38BMP6BMP6
Entrez,  Source
bone morphogenetic protein 618770.0980.3851Yes
39MRPS7MRPS7
Entrez,  Source
mitochondrial ribosomal protein S719300.0960.3870Yes
40COQ7COQ7
Entrez,  Source
coenzyme Q7 homolog, ubiquinone (yeast)20160.0930.3862No
41ADKADK
Entrez,  Source
adenosine kinase20820.0910.3868No
42EIF2B1EIF2B1
Entrez,  Source
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa23030.0850.3753No
43PTSPTS
Entrez,  Source
6-pyruvoyltetrahydropterin synthase24070.0820.3725No
44ABCF1ABCF1
Entrez,  Source
ATP-binding cassette, sub-family F (GCN20), member 124120.0820.3772No
45PPATPPAT
Entrez,  Source
phosphoribosyl pyrophosphate amidotransferase26130.0760.3666No
46NDST1NDST1
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 126450.0750.3688No
47CHST12CHST12
Entrez,  Source
carbohydrate (chondroitin 4) sulfotransferase 1227210.0730.3675No
48SPNSPN
Entrez,  Source
sialophorin (leukosialin, CD43)27410.0730.3705No
49COASYCOASY
Entrez,  Source
Coenzyme A synthase28610.0700.3657No
50SFTPDSFTPD
Entrez,  Source
surfactant, pulmonary-associated protein D28830.0690.3684No
51CPOXCPOX
Entrez,  Source
coproporphyrinogen oxidase29460.0680.3678No
52PEX7PEX7
Entrez,  Source
peroxisomal biogenesis factor 730290.0660.3656No
53UMPSUMPS
Entrez,  Source
uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)30350.0660.3692No
54ATF4ATF4
Entrez,  Source
activating transcription factor 4 (tax-responsive enhancer element B67)30580.0650.3715No
55CHST3CHST3
Entrez,  Source
carbohydrate (chondroitin 6) sulfotransferase 332390.0610.3615No
56EIF2B3EIF2B3
Entrez,  Source
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa32770.0610.3624No
57GMPSGMPS
Entrez,  Source
guanine monphosphate synthetase35950.0540.3416No
58UROSUROS
Entrez,  Source
uroporphyrinogen III synthase (congenital erythropoietic porphyria)38200.0490.3276No
59AGPAT1AGPAT1
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)40280.0460.3146No
60EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)40790.0450.3136No
61CYP27B1CYP27B1
Entrez,  Source
cytochrome P450, family 27, subfamily B, polypeptide 142180.0430.3057No
62AARSAARS
Entrez,  Source
alanyl-tRNA synthetase42750.0420.3039No
63TLR4TLR4
Entrez,  Source
toll-like receptor 443080.0410.3040No
64BRCA1BRCA1
Entrez,  Source
breast cancer 1, early onset43260.0410.3052No
65MRPL23MRPL23
Entrez,  Source
mitochondrial ribosomal protein L2343520.0400.3057No
66IL10IL10
Entrez,  Source
interleukin 1043860.0400.3056No
67ETF1ETF1
Entrez,  Source
eukaryotic translation termination factor 144200.0390.3055No
68ADORA2AADORA2A
Entrez,  Source
adenosine A2a receptor44390.0390.3065No
69HSD11B2HSD11B2
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 245420.0370.3010No
70EIF2B4EIF2B4
Entrez,  Source
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa45580.0370.3021No
71HPGDHPGD
Entrez,  Source
hydroxyprostaglandin dehydrogenase 15-(NAD)48030.0320.2856No
72RPL35RPL35
Entrez,  Source
ribosomal protein L3548210.0320.2862No
73EIF2B5EIF2B5
Entrez,  Source
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa48270.0320.2878No
74DHRS9DHRS9
Entrez,  Source
dehydrogenase/reductase (SDR family) member 948650.0310.2869No
75PTGS1PTGS1
Entrez,  Source
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)48870.0310.2872No
76MRPL41MRPL41
Entrez,  Source
mitochondrial ribosomal protein L4149210.0300.2865No
77TSC1TSC1
Entrez,  Source
tuberous sclerosis 149620.0300.2853No
78HSD3B1HSD3B1
Entrez,  Source
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 149970.0290.2845No
79ARPP-19ARPP-19
Entrez,  Source
-50200.0290.2846No
80COPS5COPS5
Entrez,  Source
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)50280.0290.2858No
81RPL21RPL21
Entrez,  Source
ribosomal protein L2151250.0270.2801No
82GRM8GRM8
Entrez,  Source
glutamate receptor, metabotropic 855250.0210.2511No
83ALAS2ALAS2
Entrez,  Source
aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)56060.0200.2463No
84HBS1LHBS1L
Entrez,  Source
HBS1-like (S. cerevisiae)57470.0180.2367No
85RPL4RPL4
Entrez,  Source
ribosomal protein L457690.0180.2362No
86RPL13RPL13
Entrez,  Source
ribosomal protein L1358210.0170.2334No
87APBB1APBB1
Entrez,  Source
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)60000.0140.2207No
88IL12BIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)60030.0140.2214No
89SCYE1SCYE1
Entrez,  Source
small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)60400.0140.2195No
90RPL41RPL41
Entrez,  Source
ribosomal protein L4160660.0130.2184No
91RPL14RPL14
Entrez,  Source
ribosomal protein L1462530.0100.2049No
92EIF5EIF5
Entrez,  Source
eukaryotic translation initiation factor 563110.0090.2012No
93RPS3ARPS3A
Entrez,  Source
ribosomal protein S3A63200.0090.2011No
94RPL24RPL24
Entrez,  Source
ribosomal protein L2463830.0080.1969No
95RPL37RPL37
Entrez,  Source
ribosomal protein L3764040.0080.1958No
96RPS9RPS9
Entrez,  Source
ribosomal protein S964480.0070.1930No
97IL4IL4
Entrez,  Source
interleukin 464660.0070.1921No
98RPS12RPS12
Entrez,  Source
ribosomal protein S1264670.0070.1925No
99BCL10BCL10
Entrez,  Source
B-cell CLL/lymphoma 1064710.0070.1927No
100DARSDARS
Entrez,  Source
aspartyl-tRNA synthetase64780.0070.1927No
101RPL29RPL29
Entrez,  Source
ribosomal protein L2964800.0070.1930No
102RPS17RPS17
Entrez,  Source
ribosomal protein S1764950.0060.1923No
103ASMTASMT
Entrez,  Source
acetylserotonin O-methyltransferase65180.0060.1910No
104RPL18RPL18
Entrez,  Source
ribosomal protein L1865330.0060.1903No
105RPS3RPS3
Entrez,  Source
ribosomal protein S365460.0060.1898No
106RPL28RPL28
Entrez,  Source
ribosomal protein L2865660.0060.1887No
107RPL7RPL7
Entrez,  Source
ribosomal protein L766160.0050.1853No
108RPL31RPL31
Entrez,  Source
ribosomal protein L3166410.0050.1837No
109TRSPAP1TRSPAP1
Entrez,  Source
tRNA selenocysteine associated protein 166440.0050.1839No
110GUK1GUK1
Entrez,  Source
guanylate kinase 167150.0040.1788No
111PTGDSPTGDS
Entrez,  Source
prostaglandin D2 synthase 21kDa (brain)67380.0030.1773No
112RPS11RPS11
Entrez,  Source
ribosomal protein S1168740.0020.1671No
113RPL3RPL3
Entrez,  Source
ribosomal protein L369560.0000.1610No
114INHBAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)6984-0.0000.1589No
115RPL30RPL30
Entrez,  Source
ribosomal protein L306985-0.0000.1590No
116RPL8RPL8
Entrez,  Source
ribosomal protein L87041-0.0010.1548No
117RPS10RPS10
Entrez,  Source
ribosomal protein S107076-0.0010.1523No
118RPL26RPL26
Entrez,  Source
ribosomal protein L267117-0.0020.1494No
119TNFRSF8TNFRSF8
Entrez,  Source
tumor necrosis factor receptor superfamily, member 87122-0.0020.1492No
120RPS2RPS2
Entrez,  Source
ribosomal protein S27135-0.0020.1485No
121PABPC4PABPC4
Entrez,  Source
poly(A) binding protein, cytoplasmic 4 (inducible form)7148-0.0020.1477No
122RPL9RPL9
Entrez,  Source
ribosomal protein L97163-0.0030.1468No
123GLMNGLMN
Entrez,  Source
glomulin, FKBP associated protein7210-0.0030.1435No
124RPL6RPL6
Entrez,  Source
ribosomal protein L67233-0.0030.1420No
125IL6IL6
Entrez,  Source
interleukin 6 (interferon, beta 2)7239-0.0040.1419No
126KARSKARS
Entrez,  Source
lysyl-tRNA synthetase7266-0.0040.1401No
127EEF1A1EEF1A1
Entrez,  Source
eukaryotic translation elongation factor 1 alpha 17318-0.0050.1365No
128RPS27RPS27
Entrez,  Source
ribosomal protein S27 (metallopanstimulin 1)7325-0.0050.1364No
129RPL15RPL15
Entrez,  Source
ribosomal protein L157353-0.0050.1347No
130RPS5RPS5
Entrez,  Source
ribosomal protein S57405-0.0060.1311No
131DEFB103ADEFB103A
Entrez,  Source
defensin, beta 103A7483-0.0070.1257No
132RPL5RPL5
Entrez,  Source
ribosomal protein L57524-0.0080.1232No
133RPL22RPL22
Entrez,  Source
ribosomal protein L227541-0.0080.1224No
134RPS19RPS19
Entrez,  Source
ribosomal protein S197575-0.0090.1205No
135CMPKCMPK
Entrez,  Source
cytidylate kinase7736-0.0110.1090No
136CD28CD28
Entrez,  Source
CD28 molecule7763-0.0110.1077No
137DDX25DDX25
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 257853-0.0130.1017No
138SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7883-0.0130.1003No
139RPL19RPL19
Entrez,  Source
ribosomal protein L197963-0.0140.0952No
140GHRLGHRL
Entrez,  Source
ghrelin/obestatin preprohormone7982-0.0150.0947No
141PPARGC1APPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha8036-0.0150.0916No
142HSD3B7HSD3B7
Entrez,  Source
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 78089-0.0160.0887No
143RPL11RPL11
Entrez,  Source
ribosomal protein L118243-0.0190.0782No
144PAICSPAICS
Entrez,  Source
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase8385-0.0210.0687No
145EIF5AEIF5A
Entrez,  Source
eukaryotic translation initiation factor 5A8430-0.0220.0667No
146EIF4BEIF4B
Entrez,  Source
eukaryotic translation initiation factor 4B8550-0.0240.0591No
147EIF4A2EIF4A2
Entrez,  Source
eukaryotic translation initiation factor 4A, isoform 28760-0.0270.0449No
148EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 18817-0.0280.0424No
149GHSRGHSR
Entrez,  Source
growth hormone secretagogue receptor8872-0.0290.0401No
150EIF4G2EIF4G2
Entrez,  Source
eukaryotic translation initiation factor 4 gamma, 28954-0.0310.0358No
151CYP7B1CYP7B1
Entrez,  Source
cytochrome P450, family 7, subfamily B, polypeptide 19114-0.0340.0258No
152OAZ1OAZ1
Entrez,  Source
ornithine decarboxylase antizyme 19198-0.0360.0217No
153FARS2FARS2
Entrez,  Source
phenylalanine-tRNA synthetase 2 (mitochondrial)9209-0.0360.0231No
154SPRSPR
Entrez,  Source
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)9268-0.0370.0210No
155MIFMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)9316-0.0380.0197No
156EREGEREG
Entrez,  Source
epiregulin9343-0.0390.0201No
157HSP90AB1HSP90AB1
Entrez,  Source
heat shock protein 90kDa alpha (cytosolic), class B member 19570-0.0430.0055No
158GMDSGMDS
Entrez,  Source
GDP-mannose 4,6-dehydratase9847-0.049-0.0125No
159SLC5A7SLC5A7
Entrez,  Source
solute carrier family 5 (choline transporter), member 79983-0.052-0.0196No
160CYP11A1CYP11A1
Entrez,  Source
cytochrome P450, family 11, subfamily A, polypeptide 110102-0.054-0.0253No
161EIF2B2EIF2B2
Entrez,  Source
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa10173-0.056-0.0272No
162COX15COX15
Entrez,  Source
COX15 homolog, cytochrome c oxidase assembly protein (yeast)10424-0.062-0.0424No
163ELA2ELA2
Entrez,  Source
elastase 2, neutrophil10427-0.062-0.0388No
164LTA4HLTA4H
Entrez,  Source
leukotriene A4 hydrolase10430-0.062-0.0351No
165AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 110634-0.068-0.0464No
166ALDH9A1ALDH9A1
Entrez,  Source
aldehyde dehydrogenase 9 family, member A110674-0.069-0.0452No
167HSP90AA1HSP90AA1
Entrez,  Source
heat shock protein 90kDa alpha (cytosolic), class A member 110705-0.070-0.0432No
168HPRT1HPRT1
Entrez,  Source
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)10730-0.071-0.0407No
169WARSWARS
Entrez,  Source
tryptophanyl-tRNA synthetase10801-0.073-0.0416No
170AP3D1AP3D1
Entrez,  Source
adaptor-related protein complex 3, delta 1 subunit10841-0.074-0.0401No
171BACE2BACE2
Entrez,  Source
beta-site APP-cleaving enzyme 210980-0.078-0.0459No
172TSPOTSPO
Entrez,  Source
translocator protein (18kDa)11004-0.079-0.0428No
173DEGS1DEGS1
Entrez,  Source
degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)11324-0.092-0.0615No
174GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)11580-0.103-0.0746No
175IL17FIL17F
Entrez,  Source
interleukin 17F11826-0.115-0.0862No
176TGFB2TGFB2
Entrez,  Source
transforming growth factor, beta 212112-0.132-0.0998No
177AGPAT6AGPAT6
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)12308-0.149-0.1056No
178EEF2KEEF2K
Entrez,  Source
eukaryotic elongation factor-2 kinase12382-0.156-0.1016No
179EIF2AK3EIF2AK3
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 312512-0.172-0.1010No
180TYMSTYMS
Entrez,  Source
thymidylate synthetase12607-0.185-0.0968No
181PLOD1PLOD1
Entrez,  Source
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 112626-0.189-0.0867No
182HSPB1HSPB1
Entrez,  Source
heat shock 27kDa protein 112847-0.236-0.0891No
183DDAH2DDAH2
Entrez,  Source
dimethylarginine dimethylaminohydrolase 212900-0.253-0.0776No
184CD276CD276
Entrez,  Source
CD276 molecule13052-0.320-0.0696No
185PLCE1PLCE1
Entrez,  Source
phospholipase C, epsilon 113110-0.363-0.0518No
186BCAT1BCAT1
Entrez,  Source
branched chain aminotransferase 1, cytosolic13181-0.442-0.0303No
187ADMADM
Entrez,  Source
adrenomedullin13287-0.6970.0042No
Table: GSEA details [plain text format]



Fig 2: CELLULAR_BIOSYNTHETIC_PROCESS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CELLULAR_BIOSYNTHETIC_PROCESS: Random ES distribution   
Gene set null distribution of ES for CELLULAR_BIOSYNTHETIC_PROCESS