Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | CELL_CYCLE |
| Enrichment Score (ES) | -0.6726768 |
| Normalized Enrichment Score (NES) | -2.0314784 |
| Nominal p-value | 0.0017513135 |
| FDR q-value | 0.0044613355 |
| FWER p-Value | 0.095 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAD2L2 | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 1355 | 0.121 | -0.0827 | No |
| 2 | CCNH | CCNH Entrez, Source | cyclin H | 1938 | 0.096 | -0.1112 | No |
| 3 | CDC25A | CDC25A Entrez, Source | cell division cycle 25A | 2527 | 0.079 | -0.1429 | No |
| 4 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 2560 | 0.078 | -0.1329 | No |
| 5 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2746 | 0.073 | -0.1353 | No |
| 6 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2765 | 0.072 | -0.1251 | No |
| 7 | ORC4L | ORC4L Entrez, Source | origin recognition complex, subunit 4-like (yeast) | 4185 | 0.043 | -0.2250 | No |
| 8 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4948 | 0.030 | -0.2775 | No |
| 9 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 5968 | 0.015 | -0.3518 | No |
| 10 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.3641 | No |
| 11 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | -0.4085 | No |
| 12 | HDAC3 | HDAC3 Entrez, Source | histone deacetylase 3 | 6844 | 0.002 | -0.4147 | No |
| 13 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8216 | -0.018 | -0.5149 | No |
| 14 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.5194 | No |
| 15 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 8384 | -0.021 | -0.5209 | No |
| 16 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 8998 | -0.032 | -0.5619 | No |
| 17 | ORC1L | ORC1L Entrez, Source | origin recognition complex, subunit 1-like (yeast) | 9519 | -0.042 | -0.5943 | No |
| 18 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 9869 | -0.049 | -0.6127 | No |
| 19 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9946 | -0.051 | -0.6103 | No |
| 20 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 10068 | -0.053 | -0.6110 | No |
| 21 | ORC3L | ORC3L Entrez, Source | origin recognition complex, subunit 3-like (yeast) | 10375 | -0.061 | -0.6243 | No |
| 22 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 10788 | -0.072 | -0.6438 | No |
| 23 | HDAC6 | HDAC6 Entrez, Source | histone deacetylase 6 | 11173 | -0.085 | -0.6592 | Yes |
| 24 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 11317 | -0.091 | -0.6555 | Yes |
| 25 | HDAC5 | HDAC5 Entrez, Source | histone deacetylase 5 | 11330 | -0.092 | -0.6418 | Yes |
| 26 | YWHAG | YWHAG Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 11367 | -0.093 | -0.6296 | Yes |
| 27 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 11474 | -0.098 | -0.6220 | Yes |
| 28 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 11568 | -0.103 | -0.6127 | Yes |
| 29 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11886 | -0.118 | -0.6178 | Yes |
| 30 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 12256 | -0.144 | -0.6226 | Yes |
| 31 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12272 | -0.146 | -0.6006 | Yes |
| 32 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.5836 | Yes |
| 33 | CDC25B | CDC25B Entrez, Source | cell division cycle 25B | 12377 | -0.156 | -0.5589 | Yes |
| 34 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 12413 | -0.160 | -0.5362 | Yes |
| 35 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 12445 | -0.163 | -0.5126 | Yes |
| 36 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12725 | -0.209 | -0.5004 | Yes |
| 37 | PTTG1 | PTTG1 Entrez, Source | pituitary tumor-transforming 1 | 12752 | -0.214 | -0.4683 | Yes |
| 38 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 12774 | -0.218 | -0.4353 | Yes |
| 39 | HDAC7A | HDAC7A Entrez, Source | histone deacetylase 7A | 12873 | -0.243 | -0.4041 | Yes |
| 40 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 12929 | -0.262 | -0.3666 | Yes |
| 41 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12949 | -0.272 | -0.3248 | Yes |
| 42 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13080 | -0.340 | -0.2806 | Yes |
| 43 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 13131 | -0.385 | -0.2232 | Yes |
| 44 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13267 | -0.614 | -0.1358 | Yes |
| 45 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13314 | -0.890 | 0.0021 | Yes |
