Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | CELL_CYCLE_KEGG |
| Enrichment Score (ES) | -0.6475904 |
| Normalized Enrichment Score (NES) | -2.029313 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004392351 |
| FWER p-Value | 0.097 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAD2L2 | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 1355 | 0.121 | -0.0828 | No |
| 2 | CCNH | CCNH Entrez, Source | cyclin H | 1938 | 0.096 | -0.1114 | No |
| 3 | CDC25A | CDC25A Entrez, Source | cell division cycle 25A | 2527 | 0.079 | -0.1431 | No |
| 4 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 2560 | 0.078 | -0.1332 | No |
| 5 | MPEG1 | MPEG1 Entrez, Source | - | 2724 | 0.073 | -0.1339 | No |
| 6 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2765 | 0.072 | -0.1255 | No |
| 7 | ORC4L | ORC4L Entrez, Source | origin recognition complex, subunit 4-like (yeast) | 4185 | 0.043 | -0.2254 | No |
| 8 | DTX4 | DTX4 Entrez, Source | deltex 4 homolog (Drosophila) | 4922 | 0.030 | -0.2760 | No |
| 9 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4948 | 0.030 | -0.2731 | No |
| 10 | CDH1 | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 5315 | 0.024 | -0.2968 | No |
| 11 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 5968 | 0.015 | -0.3435 | No |
| 12 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.3558 | No |
| 13 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | -0.4002 | No |
| 14 | HDAC3 | HDAC3 Entrez, Source | histone deacetylase 3 | 6844 | 0.002 | -0.4065 | No |
| 15 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8216 | -0.018 | -0.5067 | No |
| 16 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.5112 | No |
| 17 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 8384 | -0.021 | -0.5126 | No |
| 18 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 8736 | -0.027 | -0.5348 | No |
| 19 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 8998 | -0.032 | -0.5493 | No |
| 20 | ORC1L | ORC1L Entrez, Source | origin recognition complex, subunit 1-like (yeast) | 9519 | -0.042 | -0.5818 | No |
| 21 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 9869 | -0.049 | -0.6003 | No |
| 22 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9946 | -0.051 | -0.5979 | No |
| 23 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 10068 | -0.053 | -0.5986 | No |
| 24 | ORC3L | ORC3L Entrez, Source | origin recognition complex, subunit 3-like (yeast) | 10375 | -0.061 | -0.6120 | No |
| 25 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 10788 | -0.072 | -0.6316 | No |
| 26 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 11002 | -0.079 | -0.6352 | Yes |
| 27 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 11091 | -0.082 | -0.6289 | Yes |
| 28 | HDAC6 | HDAC6 Entrez, Source | histone deacetylase 6 | 11173 | -0.085 | -0.6216 | Yes |
| 29 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 11317 | -0.091 | -0.6179 | Yes |
| 30 | HDAC5 | HDAC5 Entrez, Source | histone deacetylase 5 | 11330 | -0.092 | -0.6043 | Yes |
| 31 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 11474 | -0.098 | -0.5994 | Yes |
| 32 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 11568 | -0.103 | -0.5902 | Yes |
| 33 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 12256 | -0.144 | -0.6191 | Yes |
| 34 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12272 | -0.146 | -0.5972 | Yes |
| 35 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.5804 | Yes |
| 36 | CDC25B | CDC25B Entrez, Source | cell division cycle 25B | 12377 | -0.156 | -0.5558 | Yes |
| 37 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 12413 | -0.160 | -0.5332 | Yes |
| 38 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 12445 | -0.163 | -0.5097 | Yes |
| 39 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12725 | -0.209 | -0.4977 | Yes |
| 40 | PTTG1 | PTTG1 Entrez, Source | pituitary tumor-transforming 1 | 12752 | -0.214 | -0.4658 | Yes |
| 41 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 12774 | -0.218 | -0.4330 | Yes |
| 42 | HDAC7A | HDAC7A Entrez, Source | histone deacetylase 7A | 12873 | -0.243 | -0.4019 | Yes |
| 43 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 12929 | -0.262 | -0.3647 | Yes |
| 44 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12949 | -0.272 | -0.3231 | Yes |
| 45 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13080 | -0.340 | -0.2791 | Yes |
| 46 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 13131 | -0.385 | -0.2220 | Yes |
| 47 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13267 | -0.614 | -0.1351 | Yes |
| 48 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13314 | -0.890 | 0.0021 | Yes |
