Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | CELL_CYCLE_PROCESS |
| Enrichment Score (ES) | -0.48575956 |
| Normalized Enrichment Score (NES) | -1.7025044 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.06268782 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MDM4 | MDM4 Entrez, Source | Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) | 141 | 0.366 | 0.0280 | No |
| 2 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 986 | 0.146 | -0.0203 | No |
| 3 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 1137 | 0.135 | -0.0174 | No |
| 4 | NOLC1 | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 1277 | 0.125 | -0.0146 | No |
| 5 | KATNA1 | KATNA1 Entrez, Source | katanin p60 (ATPase-containing) subunit A 1 | 1345 | 0.122 | -0.0068 | No |
| 6 | MAD2L2 | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 1355 | 0.121 | 0.0053 | No |
| 7 | SUGT1 | SUGT1 Entrez, Source | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 1681 | 0.106 | -0.0081 | No |
| 8 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1748 | 0.103 | -0.0022 | No |
| 9 | TBRG4 | TBRG4 Entrez, Source | transforming growth factor beta regulator 4 | 2019 | 0.093 | -0.0127 | No |
| 10 | SPDYA | SPDYA Entrez, Source | speedy homolog A (Drosophila) | 2536 | 0.079 | -0.0433 | No |
| 11 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2746 | 0.073 | -0.0514 | No |
| 12 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2765 | 0.072 | -0.0452 | No |
| 13 | DUSP13 | DUSP13 Entrez, Source | dual specificity phosphatase 13 | 2997 | 0.067 | -0.0556 | No |
| 14 | RAD17 | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 3607 | 0.054 | -0.0959 | No |
| 15 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3744 | 0.051 | -0.1008 | No |
| 16 | CDKN3 | CDKN3 Entrez, Source | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | 4390 | 0.040 | -0.1453 | No |
| 17 | PPP6C | PPP6C Entrez, Source | protein phosphatase 6, catalytic subunit | 4715 | 0.034 | -0.1661 | No |
| 18 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 5332 | 0.024 | -0.2101 | No |
| 19 | PTPRC | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 5608 | 0.020 | -0.2287 | No |
| 20 | PPP5C | PPP5C Entrez, Source | protein phosphatase 5, catalytic subunit | 5703 | 0.019 | -0.2338 | No |
| 21 | LIG3 | LIG3 Entrez, Source | ligase III, DNA, ATP-dependent | 5865 | 0.016 | -0.2443 | No |
| 22 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 5924 | 0.015 | -0.2470 | No |
| 23 | TTN | TTN Entrez, Source | titin | 5994 | 0.014 | -0.2507 | No |
| 24 | APBB1 | APBB1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 6000 | 0.014 | -0.2496 | No |
| 25 | AKAP8 | AKAP8 Entrez, Source | A kinase (PRKA) anchor protein 8 | 6151 | 0.012 | -0.2597 | No |
| 26 | CDC16 | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 6164 | 0.012 | -0.2593 | No |
| 27 | MRE11A | MRE11A Entrez, Source | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 6221 | 0.011 | -0.2624 | No |
| 28 | GSPT1 | GSPT1 Entrez, Source | G1 to S phase transition 1 | 6717 | 0.004 | -0.2994 | No |
| 29 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | -0.3018 | No |
| 30 | NEK6 | NEK6 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 6 | 6778 | 0.003 | -0.3032 | No |
| 31 | CDK10 | CDK10 Entrez, Source | cyclin-dependent kinase (CDC2-like) 10 | 6796 | 0.003 | -0.3042 | No |
| 32 | NPM2 | NPM2 Entrez, Source | nucleophosmin/nucleoplasmin, 2 | 6828 | 0.002 | -0.3063 | No |
| 33 | CHFR | CHFR Entrez, Source | checkpoint with forkhead and ring finger domains | 6893 | 0.001 | -0.3110 | No |
| 34 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 6984 | -0.000 | -0.3178 | No |
| 35 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 7074 | -0.001 | -0.3243 | No |
| 36 | CDC2L5 | CDC2L5 Entrez, Source | cell division cycle 2-like 5 (cholinesterase-related cell division controller) | 7727 | -0.011 | -0.3724 | No |
| 37 | CUL5 | CUL5 Entrez, Source | cullin 5 | 7748 | -0.011 | -0.3727 | No |
| 38 | CD28 | CD28 Entrez, Source | CD28 molecule | 7763 | -0.011 | -0.3726 | No |
| 39 | ACVR1 | ACVR1 Entrez, Source | activin A receptor, type I | 7793 | -0.012 | -0.3735 | No |
| 40 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8216 | -0.018 | -0.4034 | No |
| 41 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.4090 | No |
| 42 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 8384 | -0.021 | -0.4116 | No |
| 43 | KPNA2 | KPNA2 Entrez, Source | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 8416 | -0.022 | -0.4116 | No |
| 44 | NBN | NBN Entrez, Source | nibrin | 8726 | -0.027 | -0.4321 | No |
| 45 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 8736 | -0.027 | -0.4300 | No |
| 46 | CETN3 | CETN3 Entrez, Source | centrin, EF-hand protein, 3 (CDC31 homolog, yeast) | 8746 | -0.027 | -0.4278 | No |
| 47 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 9043 | -0.033 | -0.4466 | No |
| 48 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 9203 | -0.036 | -0.4548 | No |
| 49 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 9229 | -0.036 | -0.4529 | No |
| 50 | ZW10 | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 9270 | -0.037 | -0.4520 | No |
| 51 | CDKN2C | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 9276 | -0.037 | -0.4484 | No |
| 52 | EREG | EREG Entrez, Source | epiregulin | 9343 | -0.039 | -0.4493 | No |
| 53 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 9358 | -0.039 | -0.4463 | No |
| 54 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 9738 | -0.046 | -0.4700 | No |
| 55 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 9909 | -0.050 | -0.4775 | No |
| 56 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10008 | -0.052 | -0.4794 | Yes |
| 57 | CETN1 | CETN1 Entrez, Source | centrin, EF-hand protein, 1 | 10032 | -0.053 | -0.4756 | Yes |
| 58 | GFI1 | GFI1 Entrez, Source | growth factor independent 1 | 10061 | -0.053 | -0.4721 | Yes |
| 59 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 10104 | -0.054 | -0.4695 | Yes |
| 60 | SC65 | SC65 Entrez, Source | - | 10286 | -0.059 | -0.4769 | Yes |
| 61 | DCTN2 | DCTN2 Entrez, Source | dynactin 2 (p50) | 10348 | -0.060 | -0.4752 | Yes |
| 62 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 10467 | -0.063 | -0.4774 | Yes |
| 63 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 10523 | -0.065 | -0.4747 | Yes |
| 64 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 10647 | -0.068 | -0.4768 | Yes |
| 65 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 10686 | -0.069 | -0.4723 | Yes |
| 66 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 10695 | -0.070 | -0.4655 | Yes |
| 67 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 10726 | -0.071 | -0.4604 | Yes |
| 68 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 10788 | -0.072 | -0.4573 | Yes |
| 69 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 10949 | -0.077 | -0.4613 | Yes |
| 70 | USH1C | USH1C Entrez, Source | Usher syndrome 1C (autosomal recessive, severe) | 11196 | -0.086 | -0.4708 | Yes |
| 71 | ZWINT | ZWINT Entrez, Source | ZW10 interactor | 11263 | -0.089 | -0.4664 | Yes |
| 72 | KHDRBS1 | KHDRBS1 Entrez, Source | KH domain containing, RNA binding, signal transduction associated 1 | 11520 | -0.100 | -0.4752 | Yes |
| 73 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 11647 | -0.106 | -0.4734 | Yes |
| 74 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 11712 | -0.110 | -0.4667 | Yes |
| 75 | CIT | CIT Entrez, Source | citron (rho-interacting, serine/threonine kinase 21) | 11752 | -0.111 | -0.4579 | Yes |
| 76 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11886 | -0.118 | -0.4554 | Yes |
| 77 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 11905 | -0.119 | -0.4443 | Yes |
| 78 | AURKA | AURKA Entrez, Source | aurora kinase A | 11917 | -0.119 | -0.4325 | Yes |
| 79 | NDE1 | NDE1 Entrez, Source | nudE nuclear distribution gene E homolog 1 (A. nidulans) | 12075 | -0.130 | -0.4307 | Yes |
| 80 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12272 | -0.146 | -0.4301 | Yes |
| 81 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.4214 | Yes |
| 82 | CDC25B | CDC25B Entrez, Source | cell division cycle 25B | 12377 | -0.156 | -0.4050 | Yes |
| 83 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 12656 | -0.196 | -0.4053 | Yes |
| 84 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12725 | -0.209 | -0.3884 | Yes |
| 85 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 12774 | -0.218 | -0.3690 | Yes |
| 86 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 12815 | -0.228 | -0.3479 | Yes |
| 87 | TIMELESS | TIMELESS Entrez, Source | timeless homolog (Drosophila) | 12940 | -0.266 | -0.3292 | Yes |
| 88 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 12969 | -0.279 | -0.3018 | Yes |
| 89 | KIF22 | KIF22 Entrez, Source | kinesin family member 22 | 12985 | -0.285 | -0.2729 | Yes |
| 90 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 13078 | -0.337 | -0.2443 | Yes |
| 91 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13160 | -0.412 | -0.2068 | Yes |
| 92 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 13181 | -0.442 | -0.1617 | Yes |
| 93 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 13302 | -0.755 | -0.0910 | Yes |
| 94 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13314 | -0.890 | 0.0021 | Yes |
