Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.9182949 |
| Normalized Enrichment Score (NES) | 2.3548224 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 91 | 0.425 | 0.1014 | Yes |
| 2 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 136 | 0.372 | 0.1929 | Yes |
| 3 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 158 | 0.346 | 0.2793 | Yes |
| 4 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 174 | 0.334 | 0.3631 | Yes |
| 5 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 178 | 0.330 | 0.4467 | Yes |
| 6 | SQLE | SQLE Entrez, Source | squalene epoxidase | 287 | 0.271 | 0.5077 | Yes |
| 7 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 328 | 0.257 | 0.5702 | Yes |
| 8 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 366 | 0.244 | 0.6295 | Yes |
| 9 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 385 | 0.237 | 0.6884 | Yes |
| 10 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 444 | 0.218 | 0.7394 | Yes |
| 11 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 462 | 0.212 | 0.7922 | Yes |
| 12 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 512 | 0.201 | 0.8396 | Yes |
| 13 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 578 | 0.188 | 0.8826 | Yes |
| 14 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 693 | 0.174 | 0.9183 | Yes |
| 15 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1370 | 0.121 | 0.8983 | No |
