Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | CORDERO_KRAS_KD_VS_CONTROL_UP |
| Enrichment Score (ES) | -0.6040485 |
| Normalized Enrichment Score (NES) | -1.7979248 |
| Nominal p-value | 0.0034965035 |
| FDR q-value | 0.038101193 |
| FWER p-Value | 0.972 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 126 | 0.385 | 0.0373 | No |
| 2 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 613 | 0.184 | 0.0232 | No |
| 3 | INPP4B | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 895 | 0.153 | 0.0207 | No |
| 4 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 950 | 0.149 | 0.0347 | No |
| 5 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 1487 | 0.114 | 0.0083 | No |
| 6 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 1619 | 0.108 | 0.0115 | No |
| 7 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1856 | 0.099 | 0.0058 | No |
| 8 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 1874 | 0.098 | 0.0165 | No |
| 9 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 2717 | 0.073 | -0.0379 | No |
| 10 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 3018 | 0.066 | -0.0524 | No |
| 11 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 3239 | 0.061 | -0.0615 | No |
| 12 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3864 | 0.049 | -0.1025 | No |
| 13 | GLIPR1 | GLIPR1 Entrez, Source | GLI pathogenesis-related 1 (glioma) | 3896 | 0.049 | -0.0989 | No |
| 14 | SLC22A5 | SLC22A5 Entrez, Source | solute carrier family 22 (organic cation transporter), member 5 | 3992 | 0.047 | -0.1004 | No |
| 15 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 4713 | 0.034 | -0.1504 | No |
| 16 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 5548 | 0.021 | -0.2106 | No |
| 17 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5854 | 0.016 | -0.2315 | No |
| 18 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 6461 | 0.007 | -0.2762 | No |
| 19 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 7132 | -0.002 | -0.3263 | No |
| 20 | ADAM19 | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 7823 | -0.012 | -0.3767 | No |
| 21 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 9442 | -0.040 | -0.4935 | No |
| 22 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 9636 | -0.044 | -0.5026 | No |
| 23 | WISP2 | WISP2 Entrez, Source | WNT1 inducible signaling pathway protein 2 | 10285 | -0.059 | -0.5442 | No |
| 24 | ATP2B4 | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 10340 | -0.060 | -0.5410 | No |
| 25 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 10487 | -0.064 | -0.5442 | No |
| 26 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10774 | -0.072 | -0.5570 | No |
| 27 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 10796 | -0.072 | -0.5497 | No |
| 28 | MGEA5 | MGEA5 Entrez, Source | meningioma expressed antigen 5 (hyaluronidase) | 11364 | -0.093 | -0.5810 | No |
| 29 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 11419 | -0.096 | -0.5735 | No |
| 30 | IGSF4 | IGSF4 Entrez, Source | immunoglobulin superfamily, member 4 | 11649 | -0.107 | -0.5777 | No |
| 31 | WASPIP | WASPIP Entrez, Source | Wiskott-Aldrich syndrome protein interacting protein | 11720 | -0.110 | -0.5696 | No |
| 32 | JUN | JUN Entrez, Source | jun oncogene | 11756 | -0.111 | -0.5587 | No |
| 33 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 12112 | -0.132 | -0.5694 | No |
| 34 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 12574 | -0.181 | -0.5821 | Yes |
| 35 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 12690 | -0.203 | -0.5661 | Yes |
| 36 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 12735 | -0.210 | -0.5438 | Yes |
| 37 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 12847 | -0.236 | -0.5235 | Yes |
| 38 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 12937 | -0.264 | -0.4981 | Yes |
| 39 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 12978 | -0.283 | -0.4667 | Yes |
| 40 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 13011 | -0.297 | -0.4330 | Yes |
| 41 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13125 | -0.378 | -0.3956 | Yes |
| 42 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13317 | -0.925 | -0.2976 | Yes |
| 43 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 13322 | -0.989 | -0.1777 | Yes |
| 44 | TAGLN | TAGLN Entrez, Source | transgelin | 13339 | -1.475 | 0.0002 | Yes |
