Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | CYTOSKELETAL_PROTEIN_BINDING |
| Enrichment Score (ES) | -0.63771296 |
| Normalized Enrichment Score (NES) | -2.1932538 |
| Nominal p-value | 0.0 |
| FDR q-value | 5.5415276E-4 |
| FWER p-Value | 0.0040 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ADD2 | ADD2 Entrez, Source | adducin 2 (beta) | 635 | 0.182 | -0.0332 | No |
| 2 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 686 | 0.175 | -0.0228 | No |
| 3 | NRCAM | NRCAM Entrez, Source | neuronal cell adhesion molecule | 696 | 0.174 | -0.0094 | No |
| 4 | SPTBN4 | SPTBN4 Entrez, Source | spectrin, beta, non-erythrocytic 4 | 804 | 0.162 | -0.0043 | No |
| 5 | LRPPRC | LRPPRC Entrez, Source | leucine-rich PPR-motif containing | 838 | 0.159 | 0.0061 | No |
| 6 | KATNA1 | KATNA1 Entrez, Source | katanin p60 (ATPase-containing) subunit A 1 | 1345 | 0.122 | -0.0222 | No |
| 7 | MAPK8IP3 | MAPK8IP3 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 3 | 1461 | 0.115 | -0.0216 | No |
| 8 | SCIN | SCIN Entrez, Source | scinderin | 1491 | 0.114 | -0.0145 | No |
| 9 | HOOK3 | HOOK3 Entrez, Source | hook homolog 3 (Drosophila) | 1882 | 0.098 | -0.0360 | No |
| 10 | RHAG | RHAG Entrez, Source | Rh-associated glycoprotein | 2003 | 0.094 | -0.0374 | No |
| 11 | GC | GC Entrez, Source | group-specific component (vitamin D binding protein) | 2397 | 0.082 | -0.0604 | No |
| 12 | TNNI3 | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 2763 | 0.072 | -0.0821 | No |
| 13 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 3365 | 0.059 | -0.1227 | No |
| 14 | TNNT1 | TNNT1 Entrez, Source | troponin T type 1 (skeletal, slow) | 3563 | 0.055 | -0.1331 | No |
| 15 | UXT | UXT Entrez, Source | ubiquitously-expressed transcript | 3680 | 0.052 | -0.1376 | No |
| 16 | CENPJ | CENPJ Entrez, Source | centromere protein J | 3740 | 0.051 | -0.1380 | No |
| 17 | ABRA | ABRA Entrez, Source | actin-binding Rho activating protein | 4015 | 0.046 | -0.1549 | No |
| 18 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 4079 | 0.045 | -0.1560 | No |
| 19 | DCX | DCX Entrez, Source | doublecortex; lissencephaly, X-linked (doublecortin) | 4710 | 0.034 | -0.2008 | No |
| 20 | TNNT2 | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 4891 | 0.031 | -0.2118 | No |
| 21 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 5332 | 0.024 | -0.2431 | No |
| 22 | ANK1 | ANK1 Entrez, Source | ankyrin 1, erythrocytic | 5713 | 0.019 | -0.2703 | No |
| 23 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 5924 | 0.015 | -0.2849 | No |
| 24 | RHCG | RHCG Entrez, Source | Rh family, C glycoprotein | 5941 | 0.015 | -0.2848 | No |
| 25 | TTN | TTN Entrez, Source | titin | 5994 | 0.014 | -0.2876 | No |
| 26 | MYBPC1 | MYBPC1 Entrez, Source | myosin binding protein C, slow type | 6054 | 0.013 | -0.2910 | No |
| 27 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 6233 | 0.011 | -0.3035 | No |
| 28 | RAE1 | RAE1 Entrez, Source | RAE1 RNA export 1 homolog (S. pombe) | 6289 | 0.010 | -0.3069 | No |
| 29 | ESPN | ESPN Entrez, Source | espin | 6685 | 0.004 | -0.3364 | No |
| 30 | APOE | APOE Entrez, Source | apolipoprotein E | 6859 | 0.002 | -0.3493 | No |
| 31 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 6958 | 0.000 | -0.3566 | No |
| 32 | NCALD | NCALD Entrez, Source | neurocalcin delta | 7040 | -0.001 | -0.3627 | No |
| 33 | TRIM63 | TRIM63 Entrez, Source | tripartite motif-containing 63 | 7180 | -0.003 | -0.3729 | No |
| 34 | MEFV | MEFV Entrez, Source | Mediterranean fever | 7182 | -0.003 | -0.3728 | No |
| 35 | S100B | S100B Entrez, Source | S100 calcium binding protein B | 7193 | -0.003 | -0.3733 | No |
| 36 | TNNC1 | TNNC1 Entrez, Source | troponin C type 1 (slow) | 7348 | -0.005 | -0.3845 | No |
| 37 | MAPK8IP2 | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 7361 | -0.005 | -0.3850 | No |
| 38 | RPH3AL | RPH3AL Entrez, Source | rabphilin 3A-like (without C2 domains) | 7366 | -0.005 | -0.3848 | No |
| 39 | GABARAP | GABARAP Entrez, Source | GABA(A) receptor-associated protein | 7459 | -0.007 | -0.3912 | No |
| 40 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 7754 | -0.011 | -0.4125 | No |
| 41 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 8191 | -0.018 | -0.4439 | No |
| 42 | GABARAPL2 | GABARAPL2 Entrez, Source | GABA(A) receptor-associated protein-like 2 | 8493 | -0.023 | -0.4648 | No |
| 43 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8581 | -0.024 | -0.4694 | No |
| 44 | POLB | POLB Entrez, Source | polymerase (DNA directed), beta | 9135 | -0.035 | -0.5083 | No |
| 45 | HPCA | HPCA Entrez, Source | hippocalcin | 9596 | -0.043 | -0.5395 | No |
| 46 | TMOD2 | TMOD2 Entrez, Source | tropomodulin 2 (neuronal) | 9605 | -0.044 | -0.5366 | No |
| 47 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 9737 | -0.046 | -0.5427 | No |
| 48 | CCR5 | CCR5 Entrez, Source | chemokine (C-C motif) receptor 5 | 9822 | -0.048 | -0.5451 | No |
| 49 | APC | APC Entrez, Source | adenomatosis polyposis coli | 9845 | -0.049 | -0.5428 | No |
| 50 | SYNPO | SYNPO Entrez, Source | synaptopodin | 9931 | -0.051 | -0.5451 | No |
| 51 | VAPB | VAPB Entrez, Source | VAMP (vesicle-associated membrane protein)-associated protein B and C | 10075 | -0.054 | -0.5516 | No |
| 52 | MARCKS | MARCKS Entrez, Source | myristoylated alanine-rich protein kinase C substrate | 10092 | -0.054 | -0.5484 | No |
| 53 | DBNL | DBNL Entrez, Source | drebrin-like | 10207 | -0.057 | -0.5524 | No |
| 54 | KIF1B | KIF1B Entrez, Source | kinesin family member 1B | 10358 | -0.060 | -0.5588 | No |
| 55 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 10830 | -0.073 | -0.5884 | No |
| 56 | TMOD3 | TMOD3 Entrez, Source | tropomodulin 3 (ubiquitous) | 10944 | -0.077 | -0.5907 | No |
| 57 | PACSIN3 | PACSIN3 Entrez, Source | protein kinase C and casein kinase substrate in neurons 3 | 11061 | -0.081 | -0.5929 | No |
| 58 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 11531 | -0.101 | -0.6202 | No |
| 59 | CDK5RAP2 | CDK5RAP2 Entrez, Source | CDK5 regulatory subunit associated protein 2 | 11579 | -0.103 | -0.6153 | No |
| 60 | CLASP2 | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 11749 | -0.111 | -0.6191 | No |
| 61 | BAIAP2 | BAIAP2 Entrez, Source | BAI1-associated protein 2 | 11997 | -0.125 | -0.6276 | Yes |
| 62 | JUP | JUP Entrez, Source | junction plakoglobin | 12003 | -0.125 | -0.6179 | Yes |
| 63 | TLN1 | TLN1 Entrez, Source | talin 1 | 12039 | -0.127 | -0.6102 | Yes |
| 64 | DYNC1I1 | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 12058 | -0.129 | -0.6011 | Yes |
| 65 | NDE1 | NDE1 Entrez, Source | nudE nuclear distribution gene E homolog 1 (A. nidulans) | 12075 | -0.130 | -0.5918 | Yes |
| 66 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 12109 | -0.132 | -0.5836 | Yes |
| 67 | MYO9B | MYO9B Entrez, Source | myosin IXB | 12134 | -0.133 | -0.5746 | Yes |
| 68 | CAPZB | CAPZB Entrez, Source | capping protein (actin filament) muscle Z-line, beta | 12231 | -0.142 | -0.5704 | Yes |
| 69 | ADD1 | ADD1 Entrez, Source | adducin 1 (alpha) | 12334 | -0.152 | -0.5658 | Yes |
| 70 | LSP1 | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 12383 | -0.156 | -0.5567 | Yes |
| 71 | SMTN | SMTN Entrez, Source | smoothelin | 12423 | -0.161 | -0.5466 | Yes |
| 72 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12456 | -0.165 | -0.5357 | Yes |
| 73 | ABI1 | ABI1 Entrez, Source | abl-interactor 1 | 12600 | -0.184 | -0.5315 | Yes |
| 74 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 12656 | -0.196 | -0.5198 | Yes |
| 75 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 12690 | -0.203 | -0.5058 | Yes |
| 76 | PXN | PXN Entrez, Source | paxillin | 12740 | -0.211 | -0.4924 | Yes |
| 77 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 12803 | -0.226 | -0.4788 | Yes |
| 78 | SORBS2 | SORBS2 Entrez, Source | sorbin and SH3 domain containing 2 | 12846 | -0.236 | -0.4629 | Yes |
| 79 | ACTN4 | ACTN4 Entrez, Source | actinin, alpha 4 | 12871 | -0.243 | -0.4450 | Yes |
| 80 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 12914 | -0.257 | -0.4274 | Yes |
| 81 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 12969 | -0.279 | -0.4088 | Yes |
| 82 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 13038 | -0.313 | -0.3886 | Yes |
| 83 | ABI2 | ABI2 Entrez, Source | abl interactor 2 | 13159 | -0.411 | -0.3644 | Yes |
| 84 | FXYD5 | FXYD5 Entrez, Source | FXYD domain containing ion transport regulator 5 | 13236 | -0.522 | -0.3278 | Yes |
| 85 | NEXN | NEXN Entrez, Source | nexilin (F actin binding protein) | 13256 | -0.568 | -0.2832 | Yes |
| 86 | PDLIM5 | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 13261 | -0.575 | -0.2369 | Yes |
| 87 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13279 | -0.655 | -0.1851 | Yes |
| 88 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 13302 | -0.755 | -0.1256 | Yes |
| 89 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.586 | 0.0002 | Yes |
