Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS |
| Enrichment Score (ES) | -0.5200978 |
| Normalized Enrichment Score (NES) | -1.8510109 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0282376 |
| FWER p-Value | 0.806 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 50 | 0.500 | 0.0316 | No |
| 2 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 686 | 0.175 | -0.0040 | No |
| 3 | SPTBN4 | SPTBN4 Entrez, Source | spectrin, beta, non-erythrocytic 4 | 804 | 0.162 | -0.0014 | No |
| 4 | LRPPRC | LRPPRC Entrez, Source | leucine-rich PPR-motif containing | 838 | 0.159 | 0.0073 | No |
| 5 | SNAP29 | SNAP29 Entrez, Source | synaptosomal-associated protein, 29kDa | 944 | 0.149 | 0.0099 | No |
| 6 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 1006 | 0.144 | 0.0155 | No |
| 7 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 1137 | 0.135 | 0.0152 | No |
| 8 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 1352 | 0.121 | 0.0076 | No |
| 9 | SCIN | SCIN Entrez, Source | scinderin | 1491 | 0.114 | 0.0052 | No |
| 10 | MARK1 | MARK1 Entrez, Source | MAP/microtubule affinity-regulating kinase 1 | 1653 | 0.107 | 0.0006 | No |
| 11 | HOOK3 | HOOK3 Entrez, Source | hook homolog 3 (Drosophila) | 1882 | 0.098 | -0.0097 | No |
| 12 | ANK3 | ANK3 Entrez, Source | ankyrin 3, node of Ranvier (ankyrin G) | 1923 | 0.097 | -0.0059 | No |
| 13 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 2131 | 0.090 | -0.0152 | No |
| 14 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 2178 | 0.089 | -0.0124 | No |
| 15 | KIF1A | KIF1A Entrez, Source | kinesin family member 1A | 2255 | 0.086 | -0.0121 | No |
| 16 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 2338 | 0.084 | -0.0123 | No |
| 17 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 2783 | 0.072 | -0.0408 | No |
| 18 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 2930 | 0.068 | -0.0470 | No |
| 19 | ARHGAP4 | ARHGAP4 Entrez, Source | Rho GTPase activating protein 4 | 3242 | 0.061 | -0.0662 | No |
| 20 | NUAK2 | NUAK2 Entrez, Source | NUAK family, SNF1-like kinase, 2 | 3483 | 0.056 | -0.0804 | No |
| 21 | UXT | UXT Entrez, Source | ubiquitously-expressed transcript | 3680 | 0.052 | -0.0915 | No |
| 22 | CENPJ | CENPJ Entrez, Source | centromere protein J | 3740 | 0.051 | -0.0924 | No |
| 23 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3744 | 0.051 | -0.0890 | No |
| 24 | TESK2 | TESK2 Entrez, Source | testis-specific kinase 2 | 3813 | 0.050 | -0.0906 | No |
| 25 | NUBP1 | NUBP1 Entrez, Source | nucleotide binding protein 1 (MinD homolog, E. coli) | 4595 | 0.036 | -0.1472 | No |
| 26 | CCL3 | CCL3 Entrez, Source | chemokine (C-C motif) ligand 3 | 4784 | 0.033 | -0.1591 | No |
| 27 | TNNT2 | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 4891 | 0.031 | -0.1649 | No |
| 28 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 4951 | 0.030 | -0.1672 | No |
| 29 | TSC1 | TSC1 Entrez, Source | tuberous sclerosis 1 | 4962 | 0.030 | -0.1659 | No |
| 30 | STX5 | STX5 Entrez, Source | syntaxin 5 | 4988 | 0.029 | -0.1657 | No |
| 31 | APBA1 | APBA1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) | 5106 | 0.028 | -0.1726 | No |
| 32 | SEPT5 | SEPT5 Entrez, Source | septin 5 | 5197 | 0.026 | -0.1776 | No |
| 33 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 5321 | 0.024 | -0.1851 | No |
| 34 | OPA1 | OPA1 Entrez, Source | optic atrophy 1 (autosomal dominant) | 5620 | 0.020 | -0.2063 | No |
| 35 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5854 | 0.016 | -0.2227 | No |
| 36 | TTN | TTN Entrez, Source | titin | 5994 | 0.014 | -0.2322 | No |
| 37 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 6018 | 0.014 | -0.2330 | No |
| 38 | TMED10 | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 6185 | 0.012 | -0.2447 | No |
| 39 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 6233 | 0.011 | -0.2475 | No |
| 40 | PCLO | PCLO Entrez, Source | piccolo (presynaptic cytomatrix protein) | 6297 | 0.010 | -0.2516 | No |
| 41 | PACSIN2 | PACSIN2 Entrez, Source | protein kinase C and casein kinase substrate in neurons 2 | 6347 | 0.009 | -0.2547 | No |
| 42 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 6721 | 0.004 | -0.2826 | No |
| 43 | APOE | APOE Entrez, Source | apolipoprotein E | 6859 | 0.002 | -0.2929 | No |
| 44 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 6958 | 0.000 | -0.3003 | No |
| 45 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 7002 | -0.000 | -0.3035 | No |
| 46 | MAST1 | MAST1 Entrez, Source | microtubule associated serine/threonine kinase 1 | 7033 | -0.001 | -0.3057 | No |
| 47 | YKT6 | YKT6 Entrez, Source | YKT6 v-SNARE homolog (S. cerevisiae) | 7110 | -0.002 | -0.3113 | No |
| 48 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 7143 | -0.002 | -0.3136 | No |
| 49 | KIF5A | KIF5A Entrez, Source | kinesin family member 5A | 7406 | -0.006 | -0.3330 | No |
| 50 | NEFL | NEFL Entrez, Source | neurofilament, light polypeptide 68kDa | 7686 | -0.010 | -0.3534 | No |
| 51 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7883 | -0.013 | -0.3672 | No |
| 52 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 7962 | -0.014 | -0.3721 | No |
| 53 | GHRL | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 7982 | -0.015 | -0.3725 | No |
| 54 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 8191 | -0.018 | -0.3870 | No |
| 55 | DNAJB6 | DNAJB6 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 6 | 8356 | -0.021 | -0.3979 | No |
| 56 | KPNA2 | KPNA2 Entrez, Source | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 8416 | -0.022 | -0.4008 | No |
| 57 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 8532 | -0.024 | -0.4079 | No |
| 58 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 8576 | -0.024 | -0.4094 | No |
| 59 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8581 | -0.024 | -0.4080 | No |
| 60 | PLA2G1B | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 8831 | -0.029 | -0.4248 | No |
| 61 | GHSR | GHSR Entrez, Source | growth hormone secretagogue receptor | 8872 | -0.029 | -0.4257 | No |
| 62 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 9043 | -0.033 | -0.4363 | No |
| 63 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 9203 | -0.036 | -0.4458 | No |
| 64 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 9229 | -0.036 | -0.4451 | No |
| 65 | LIMK1 | LIMK1 Entrez, Source | LIM domain kinase 1 | 9254 | -0.037 | -0.4443 | No |
| 66 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 9266 | -0.037 | -0.4425 | No |
| 67 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9287 | -0.038 | -0.4413 | No |
| 68 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 9358 | -0.039 | -0.4439 | No |
| 69 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9430 | -0.040 | -0.4464 | No |
| 70 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 9556 | -0.043 | -0.4528 | No |
| 71 | KIF4A | KIF4A Entrez, Source | kinesin family member 4A | 9748 | -0.047 | -0.4640 | No |
| 72 | APC | APC Entrez, Source | adenomatosis polyposis coli | 9845 | -0.049 | -0.4678 | No |
| 73 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 10116 | -0.055 | -0.4844 | No |
| 74 | TAOK2 | TAOK2 Entrez, Source | TAO kinase 2 | 10217 | -0.057 | -0.4879 | No |
| 75 | PLD2 | PLD2 Entrez, Source | phospholipase D2 | 10232 | -0.058 | -0.4849 | No |
| 76 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 10349 | -0.060 | -0.4894 | No |
| 77 | KIF1B | KIF1B Entrez, Source | kinesin family member 1B | 10358 | -0.060 | -0.4857 | No |
| 78 | RHOT2 | RHOT2 Entrez, Source | ras homolog gene family, member T2 | 10650 | -0.068 | -0.5029 | No |
| 79 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 10686 | -0.069 | -0.5006 | No |
| 80 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10733 | -0.071 | -0.4991 | No |
| 81 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 10829 | -0.073 | -0.5011 | No |
| 82 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 10830 | -0.073 | -0.4959 | No |
| 83 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 10847 | -0.074 | -0.4919 | No |
| 84 | NLGN1 | NLGN1 Entrez, Source | neuroligin 1 | 11147 | -0.083 | -0.5086 | No |
| 85 | THY1 | THY1 Entrez, Source | Thy-1 cell surface antigen | 11169 | -0.084 | -0.5042 | No |
| 86 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 11231 | -0.087 | -0.5027 | No |
| 87 | DES | DES Entrez, Source | desmin | 11462 | -0.098 | -0.5132 | Yes |
| 88 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11466 | -0.098 | -0.5064 | Yes |
| 89 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 11531 | -0.101 | -0.5042 | Yes |
| 90 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 11553 | -0.102 | -0.4985 | Yes |
| 91 | KATNB1 | KATNB1 Entrez, Source | katanin p80 (WD repeat containing) subunit B 1 | 11624 | -0.106 | -0.4964 | Yes |
| 92 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 11647 | -0.106 | -0.4905 | Yes |
| 93 | CLASP2 | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 11749 | -0.111 | -0.4903 | Yes |
| 94 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 11799 | -0.114 | -0.4859 | Yes |
| 95 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 11882 | -0.118 | -0.4838 | Yes |
| 96 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 11988 | -0.124 | -0.4830 | Yes |
| 97 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 12011 | -0.126 | -0.4757 | Yes |
| 98 | DYNC1I1 | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 12058 | -0.129 | -0.4701 | Yes |
| 99 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 12086 | -0.130 | -0.4629 | Yes |
| 100 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 12109 | -0.132 | -0.4552 | Yes |
| 101 | MYO9B | MYO9B Entrez, Source | myosin IXB | 12134 | -0.133 | -0.4476 | Yes |
| 102 | LASP1 | LASP1 Entrez, Source | LIM and SH3 protein 1 | 12204 | -0.140 | -0.4430 | Yes |
| 103 | PSCD2 | PSCD2 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) | 12232 | -0.142 | -0.4349 | Yes |
| 104 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12398 | -0.157 | -0.4363 | Yes |
| 105 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12456 | -0.165 | -0.4290 | Yes |
| 106 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 12492 | -0.169 | -0.4196 | Yes |
| 107 | KRT20 | KRT20 Entrez, Source | keratin 20 | 12610 | -0.186 | -0.4154 | Yes |
| 108 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 12675 | -0.199 | -0.4061 | Yes |
| 109 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12715 | -0.208 | -0.3943 | Yes |
| 110 | MYO1E | MYO1E Entrez, Source | myosin IE | 12726 | -0.209 | -0.3803 | Yes |
| 111 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12779 | -0.218 | -0.3688 | Yes |
| 112 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 12803 | -0.226 | -0.3546 | Yes |
| 113 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 12815 | -0.228 | -0.3393 | Yes |
| 114 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 12818 | -0.229 | -0.3233 | Yes |
| 115 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 12914 | -0.257 | -0.3123 | Yes |
| 116 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 12969 | -0.279 | -0.2966 | Yes |
| 117 | CDC42EP2 | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 13063 | -0.326 | -0.2806 | Yes |
| 118 | ABI2 | ABI2 Entrez, Source | abl interactor 2 | 13159 | -0.411 | -0.2587 | Yes |
| 119 | NEXN | NEXN Entrez, Source | nexilin (F actin binding protein) | 13256 | -0.568 | -0.2257 | Yes |
| 120 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 13302 | -0.755 | -0.1757 | Yes |
| 121 | DBN1 | DBN1 Entrez, Source | drebrin 1 | 13318 | -0.939 | -0.1104 | Yes |
| 122 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.586 | 0.0002 | Yes |
