Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | G1_TO_S_CELL_CYCLE_REACTOME |
| Enrichment Score (ES) | -0.56589174 |
| Normalized Enrichment Score (NES) | -1.7087351 |
| Nominal p-value | 0.012323944 |
| FDR q-value | 0.060343947 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CREB3L3 | CREB3L3 Entrez, Source | cAMP responsive element binding protein 3-like 3 | 745 | 0.168 | -0.0211 | No |
| 2 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1609 | 0.108 | -0.0634 | No |
| 3 | CCNH | CCNH Entrez, Source | cyclin H | 1938 | 0.096 | -0.0681 | No |
| 4 | CDC25A | CDC25A Entrez, Source | cell division cycle 25A | 2527 | 0.079 | -0.0960 | No |
| 5 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 2560 | 0.078 | -0.0822 | No |
| 6 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2765 | 0.072 | -0.0825 | No |
| 7 | CREB3L1 | CREB3L1 Entrez, Source | cAMP responsive element binding protein 3-like 1 | 3404 | 0.058 | -0.1184 | No |
| 8 | ORC4L | ORC4L Entrez, Source | origin recognition complex, subunit 4-like (yeast) | 4185 | 0.043 | -0.1681 | No |
| 9 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4948 | 0.030 | -0.2191 | No |
| 10 | CREB3L4 | CREB3L4 Entrez, Source | cAMP responsive element binding protein 3-like 4 | 5827 | 0.017 | -0.2816 | No |
| 11 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 5968 | 0.015 | -0.2891 | No |
| 12 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.3008 | No |
| 13 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | -0.3450 | No |
| 14 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 7269 | -0.004 | -0.3827 | No |
| 15 | CREBL1 | CREBL1 Entrez, Source | cAMP responsive element binding protein-like 1 | 7346 | -0.005 | -0.3874 | No |
| 16 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8216 | -0.018 | -0.4489 | No |
| 17 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.4524 | No |
| 18 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 8384 | -0.021 | -0.4528 | No |
| 19 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 8462 | -0.022 | -0.4540 | No |
| 20 | CDKN2C | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 9276 | -0.037 | -0.5073 | No |
| 21 | ORC1L | ORC1L Entrez, Source | origin recognition complex, subunit 1-like (yeast) | 9519 | -0.042 | -0.5168 | No |
| 22 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 9869 | -0.049 | -0.5328 | No |
| 23 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9946 | -0.051 | -0.5279 | No |
| 24 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10008 | -0.052 | -0.5216 | No |
| 25 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 10068 | -0.053 | -0.5150 | No |
| 26 | ORC3L | ORC3L Entrez, Source | origin recognition complex, subunit 3-like (yeast) | 10375 | -0.061 | -0.5253 | No |
| 27 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 10726 | -0.071 | -0.5370 | No |
| 28 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 10949 | -0.077 | -0.5377 | No |
| 29 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 11124 | -0.083 | -0.5336 | No |
| 30 | MNAT1 | MNAT1 Entrez, Source | menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) | 11555 | -0.102 | -0.5447 | Yes |
| 31 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 11568 | -0.103 | -0.5243 | Yes |
| 32 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 11676 | -0.108 | -0.5099 | Yes |
| 33 | PRIM2A | PRIM2A Entrez, Source | primase, polypeptide 2A, 58kDa | 11731 | -0.111 | -0.4910 | Yes |
| 34 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11886 | -0.118 | -0.4780 | Yes |
| 35 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12272 | -0.146 | -0.4766 | Yes |
| 36 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.4520 | Yes |
| 37 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 12413 | -0.160 | -0.4215 | Yes |
| 38 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 12673 | -0.198 | -0.3998 | Yes |
| 39 | CREB3 | CREB3 Entrez, Source | cAMP responsive element binding protein 3 | 12781 | -0.218 | -0.3624 | Yes |
| 40 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 12929 | -0.262 | -0.3190 | Yes |
| 41 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13080 | -0.340 | -0.2595 | Yes |
| 42 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13085 | -0.343 | -0.1886 | Yes |
| 43 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 13131 | -0.385 | -0.1119 | Yes |
| 44 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13267 | -0.614 | 0.0056 | Yes |
