Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY |
| Enrichment Score (ES) | 0.43933424 |
| Normalized Enrichment Score (NES) | 1.6135862 |
| Nominal p-value | 0.005154639 |
| FDR q-value | 0.0634653 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ADH7 | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 53 | 0.495 | 0.0500 | Yes |
| 2 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 58 | 0.484 | 0.1024 | Yes |
| 3 | APOM | APOM Entrez, Source | apolipoprotein M | 113 | 0.401 | 0.1420 | Yes |
| 4 | GCK | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 140 | 0.368 | 0.1802 | Yes |
| 5 | LEPR | LEPR Entrez, Source | leptin receptor | 146 | 0.357 | 0.2187 | Yes |
| 6 | CEBPA | CEBPA Entrez, Source | CCAAT/enhancer binding protein (C/EBP), alpha | 203 | 0.308 | 0.2481 | Yes |
| 7 | GYS2 | GYS2 Entrez, Source | glycogen synthase 2 (liver) | 314 | 0.263 | 0.2684 | Yes |
| 8 | GCGR | GCGR Entrez, Source | glucagon receptor | 409 | 0.228 | 0.2862 | Yes |
| 9 | ACADVL | ACADVL Entrez, Source | acyl-Coenzyme A dehydrogenase, very long chain | 482 | 0.207 | 0.3034 | Yes |
| 10 | BCS1L | BCS1L Entrez, Source | BCS1-like (yeast) | 504 | 0.201 | 0.3237 | Yes |
| 11 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 563 | 0.190 | 0.3401 | Yes |
| 12 | ALDH5A1 | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 612 | 0.184 | 0.3566 | Yes |
| 13 | INSR | INSR Entrez, Source | insulin receptor | 735 | 0.169 | 0.3658 | Yes |
| 14 | DHRS4 | DHRS4 Entrez, Source | dehydrogenase/reductase (SDR family) member 4 | 788 | 0.164 | 0.3798 | Yes |
| 15 | AVP | AVP Entrez, Source | arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | 866 | 0.156 | 0.3909 | Yes |
| 16 | XYLB | XYLB Entrez, Source | xylulokinase homolog (H. influenzae) | 995 | 0.145 | 0.3971 | Yes |
| 17 | POR | POR Entrez, Source | P450 (cytochrome) oxidoreductase | 1030 | 0.142 | 0.4101 | Yes |
| 18 | CYP1B1 | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 1078 | 0.138 | 0.4216 | Yes |
| 19 | PDIA5 | PDIA5 Entrez, Source | protein disulfide isomerase family A, member 5 | 1141 | 0.134 | 0.4316 | Yes |
| 20 | PHKG2 | PHKG2 Entrez, Source | phosphorylase kinase, gamma 2 (testis) | 1373 | 0.120 | 0.4273 | Yes |
| 21 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 1387 | 0.119 | 0.4393 | Yes |
| 22 | NDUFS1 | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 1817 | 0.101 | 0.4180 | No |
| 23 | SURF1 | SURF1 Entrez, Source | surfeit 1 | 1848 | 0.100 | 0.4266 | No |
| 24 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 1859 | 0.099 | 0.4366 | No |
| 25 | PHKB | PHKB Entrez, Source | phosphorylase kinase, beta | 2515 | 0.079 | 0.3959 | No |
| 26 | SDHD | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 2529 | 0.079 | 0.4035 | No |
| 27 | EPM2A | EPM2A Entrez, Source | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 2594 | 0.077 | 0.4070 | No |
| 28 | SDHA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 2780 | 0.072 | 0.4009 | No |
| 29 | MTRR | MTRR Entrez, Source | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | 2865 | 0.070 | 0.4022 | No |
| 30 | AQP7 | AQP7 Entrez, Source | aquaporin 7 | 2868 | 0.070 | 0.4096 | No |
| 31 | AOC3 | AOC3 Entrez, Source | amine oxidase, copper containing 3 (vascular adhesion protein 1) | 2897 | 0.069 | 0.4150 | No |
| 32 | ACO2 | ACO2 Entrez, Source | aconitase 2, mitochondrial | 3136 | 0.064 | 0.4040 | No |
| 33 | UQCRC2 | UQCRC2 Entrez, Source | ubiquinol-cytochrome c reductase core protein II | 3187 | 0.063 | 0.4071 | No |
| 34 | PPARG | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 3592 | 0.054 | 0.3825 | No |
| 35 | UQCRC1 | UQCRC1 Entrez, Source | ubiquinol-cytochrome c reductase core protein I | 3903 | 0.048 | 0.3644 | No |
| 36 | COX17 | COX17 Entrez, Source | COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) | 4243 | 0.042 | 0.3434 | No |
| 37 | DLST | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 4335 | 0.040 | 0.3410 | No |
| 38 | POMC | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 4345 | 0.040 | 0.3447 | No |
| 39 | BLVRA | BLVRA Entrez, Source | biliverdin reductase A | 4380 | 0.040 | 0.3465 | No |
| 40 | CYB5R2 | CYB5R2 Entrez, Source | cytochrome b5 reductase 2 | 4527 | 0.037 | 0.3395 | No |
| 41 | QPRT | QPRT Entrez, Source | quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) | 4588 | 0.036 | 0.3390 | No |
| 42 | NDUFS4 | NDUFS4 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 4753 | 0.033 | 0.3302 | No |
| 43 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 4974 | 0.030 | 0.3169 | No |
| 44 | GBE1 | GBE1 Entrez, Source | glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) | 5119 | 0.027 | 0.3090 | No |
| 45 | ADRB3 | ADRB3 Entrez, Source | adrenergic, beta-3-, receptor | 5121 | 0.027 | 0.3119 | No |
| 46 | UQCRB | UQCRB Entrez, Source | ubiquinol-cytochrome c reductase binding protein | 5231 | 0.026 | 0.3065 | No |
| 47 | GPX4 | GPX4 Entrez, Source | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 5373 | 0.024 | 0.2984 | No |
| 48 | SDHC | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 5789 | 0.018 | 0.2690 | No |
| 49 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 5859 | 0.016 | 0.2656 | No |
| 50 | MCHR1 | MCHR1 Entrez, Source | melanin-concentrating hormone receptor 1 | 6334 | 0.009 | 0.2309 | No |
| 51 | WFS1 | WFS1 Entrez, Source | Wolfram syndrome 1 (wolframin) | 6353 | 0.009 | 0.2304 | No |
| 52 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 6391 | 0.008 | 0.2285 | No |
| 53 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6707 | 0.004 | 0.2052 | No |
| 54 | UQCRH | UQCRH Entrez, Source | ubiquinol-cytochrome c reductase hinge protein | 7358 | -0.005 | 0.1567 | No |
| 55 | TXNL1 | TXNL1 Entrez, Source | thioredoxin-like 1 | 7392 | -0.006 | 0.1549 | No |
| 56 | ENPP1 | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 7834 | -0.013 | 0.1230 | No |
| 57 | GFPT2 | GFPT2 Entrez, Source | glutamine-fructose-6-phosphate transaminase 2 | 7852 | -0.013 | 0.1231 | No |
| 58 | PYGM | PYGM Entrez, Source | phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) | 8011 | -0.015 | 0.1129 | No |
| 59 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 8036 | -0.015 | 0.1127 | No |
| 60 | RETSAT | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 8072 | -0.016 | 0.1118 | No |
| 61 | ATPIF1 | ATPIF1 Entrez, Source | ATPase inhibitory factor 1 | 8423 | -0.022 | 0.0878 | No |
| 62 | NOX4 | NOX4 Entrez, Source | NADPH oxidase 4 | 8566 | -0.024 | 0.0797 | No |
| 63 | ISL1 | ISL1 Entrez, Source | ISL1 transcription factor, LIM/homeodomain, (islet-1) | 8698 | -0.026 | 0.0727 | No |
| 64 | SPR | SPR Entrez, Source | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | 9268 | -0.037 | 0.0339 | No |
| 65 | TREH | TREH Entrez, Source | trehalase (brush-border membrane glycoprotein) | 9359 | -0.039 | 0.0313 | No |
| 66 | DUOX2 | DUOX2 Entrez, Source | dual oxidase 2 | 9524 | -0.042 | 0.0235 | No |
| 67 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 9824 | -0.048 | 0.0063 | No |
| 68 | SLC25A27 | SLC25A27 Entrez, Source | solute carrier family 25, member 27 | 9880 | -0.049 | 0.0075 | No |
| 69 | GIPR | GIPR Entrez, Source | gastric inhibitory polypeptide receptor | 9933 | -0.051 | 0.0091 | No |
| 70 | ADIPOQ | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 10637 | -0.068 | -0.0365 | No |
| 71 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10674 | -0.069 | -0.0317 | No |
| 72 | GFPT1 | GFPT1 Entrez, Source | glutamine-fructose-6-phosphate transaminase 1 | 10795 | -0.072 | -0.0328 | No |
| 73 | GAA | GAA Entrez, Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 11007 | -0.079 | -0.0402 | No |
| 74 | SLC25A3 | SLC25A3 Entrez, Source | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 11129 | -0.083 | -0.0402 | No |
| 75 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 11474 | -0.098 | -0.0554 | No |
| 76 | LEP | LEP Entrez, Source | leptin (obesity homolog, mouse) | 11481 | -0.099 | -0.0451 | No |
| 77 | CROT | CROT Entrez, Source | carnitine O-octanoyltransferase | 11691 | -0.109 | -0.0490 | No |
| 78 | PHKA1 | PHKA1 Entrez, Source | phosphorylase kinase, alpha 1 (muscle) | 12316 | -0.150 | -0.0798 | No |
| 79 | PPP1R2 | PPP1R2 Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 12496 | -0.170 | -0.0748 | No |
| 80 | PLOD1 | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 12626 | -0.189 | -0.0639 | No |
| 81 | SLC25A4 | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 12710 | -0.207 | -0.0476 | No |
| 82 | PYGB | PYGB Entrez, Source | phosphorylase, glycogen; brain | 12718 | -0.208 | -0.0254 | No |
| 83 | CRAT | CRAT Entrez, Source | carnitine acetyltransferase | 13012 | -0.297 | -0.0152 | No |
| 84 | AVPR1A | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 13117 | -0.366 | 0.0170 | No |
