Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | HSA00100_BIOSYNTHESIS_OF_STEROIDS |
| Enrichment Score (ES) | 0.8886978 |
| Normalized Enrichment Score (NES) | 2.4794989 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 60 | 0.482 | 0.0834 | Yes |
| 2 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 78 | 0.438 | 0.1621 | Yes |
| 3 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 91 | 0.425 | 0.2388 | Yes |
| 4 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 136 | 0.372 | 0.3034 | Yes |
| 5 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 158 | 0.346 | 0.3649 | Yes |
| 6 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 174 | 0.334 | 0.4246 | Yes |
| 7 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 221 | 0.298 | 0.4756 | Yes |
| 8 | VKORC1 | VKORC1 Entrez, Source | vitamin K epoxide reductase complex, subunit 1 | 275 | 0.277 | 0.5222 | Yes |
| 9 | SQLE | SQLE Entrez, Source | squalene epoxidase | 287 | 0.271 | 0.5708 | Yes |
| 10 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 328 | 0.257 | 0.6148 | Yes |
| 11 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 366 | 0.244 | 0.6565 | Yes |
| 12 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 385 | 0.237 | 0.6984 | Yes |
| 13 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 444 | 0.218 | 0.7337 | Yes |
| 14 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 462 | 0.212 | 0.7712 | Yes |
| 15 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 512 | 0.201 | 0.8041 | Yes |
| 16 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 578 | 0.188 | 0.8335 | Yes |
| 17 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 685 | 0.175 | 0.8575 | Yes |
| 18 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 693 | 0.174 | 0.8887 | Yes |
| 19 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1370 | 0.121 | 0.8599 | No |
| 20 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 1532 | 0.112 | 0.8682 | No |
| 21 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 4218 | 0.043 | 0.6744 | No |
| 22 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 5019 | 0.029 | 0.6196 | No |
| 23 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 8804 | -0.028 | 0.3407 | No |
