Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | HSA00252_ALANINE_AND_ASPARTATE_METABOLISM |
| Enrichment Score (ES) | 0.6360138 |
| Normalized Enrichment Score (NES) | 1.849432 |
| Nominal p-value | 0.0044247787 |
| FDR q-value | 0.010630132 |
| FWER p-Value | 0.703 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 110 | 0.403 | 0.1044 | Yes |
| 2 | AGXT | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 128 | 0.384 | 0.2104 | Yes |
| 3 | PC | PC Entrez, Source | pyruvate carboxylase | 155 | 0.347 | 0.3055 | Yes |
| 4 | ASL | ASL Entrez, Source | argininosuccinate lyase | 183 | 0.323 | 0.3939 | Yes |
| 5 | ABAT | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 185 | 0.321 | 0.4837 | Yes |
| 6 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 414 | 0.227 | 0.5302 | Yes |
| 7 | AGXT2 | AGXT2 Entrez, Source | alanine-glyoxylate aminotransferase 2 | 475 | 0.209 | 0.5841 | Yes |
| 8 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 563 | 0.190 | 0.6309 | Yes |
| 9 | ASS1 | ASS1 Entrez, Source | argininosuccinate synthetase 1 | 1382 | 0.120 | 0.6029 | Yes |
| 10 | ASRGL1 | ASRGL1 Entrez, Source | asparaginase like 1 | 1612 | 0.108 | 0.6160 | Yes |
| 11 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 1733 | 0.104 | 0.6360 | Yes |
| 12 | GPT | GPT Entrez, Source | glutamic-pyruvate transaminase (alanine aminotransferase) | 2146 | 0.090 | 0.6302 | No |
| 13 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 3142 | 0.063 | 0.5732 | No |
| 14 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 4162 | 0.044 | 0.5089 | No |
| 15 | ASNS | ASNS Entrez, Source | asparagine synthetase | 4245 | 0.042 | 0.5145 | No |
| 16 | AARS | AARS Entrez, Source | alanyl-tRNA synthetase | 4275 | 0.042 | 0.5240 | No |
| 17 | NARS | NARS Entrez, Source | asparaginyl-tRNA synthetase | 5426 | 0.023 | 0.4440 | No |
| 18 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 5797 | 0.017 | 0.4211 | No |
| 19 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 5916 | 0.015 | 0.4166 | No |
| 20 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 6478 | 0.007 | 0.3763 | No |
| 21 | DARS2 | DARS2 Entrez, Source | aspartyl-tRNA synthetase 2 (mitochondrial) | 7772 | -0.012 | 0.2825 | No |
| 22 | ACY3 | ACY3 Entrez, Source | aspartoacylase (aminocyclase) 3 | 9233 | -0.036 | 0.1830 | No |
| 23 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 10797 | -0.072 | 0.0859 | No |
| 24 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 10995 | -0.078 | 0.0931 | No |
| 25 | CRAT | CRAT Entrez, Source | carnitine acetyltransferase | 13012 | -0.297 | 0.0248 | No |
