Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | HSA00620_PYRUVATE_METABOLISM |
| Enrichment Score (ES) | 0.66146624 |
| Normalized Enrichment Score (NES) | 1.9673415 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0039477106 |
| FWER p-Value | 0.205 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 31 | 0.561 | 0.1399 | Yes |
| 2 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 144 | 0.362 | 0.2232 | Yes |
| 3 | PC | PC Entrez, Source | pyruvate carboxylase | 155 | 0.347 | 0.3105 | Yes |
| 4 | ACACA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 231 | 0.293 | 0.3792 | Yes |
| 5 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 414 | 0.227 | 0.4232 | Yes |
| 6 | ACAT1 | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 560 | 0.191 | 0.4606 | Yes |
| 7 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 563 | 0.190 | 0.5088 | Yes |
| 8 | ACOT12 | ACOT12 Entrez, Source | acyl-CoA thioesterase 12 | 619 | 0.184 | 0.5513 | Yes |
| 9 | ACACB | ACACB Entrez, Source | acetyl-Coenzyme A carboxylase beta | 742 | 0.168 | 0.5849 | Yes |
| 10 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 800 | 0.163 | 0.6219 | Yes |
| 11 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 819 | 0.161 | 0.6613 | Yes |
| 12 | MDH1 | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 1246 | 0.127 | 0.6615 | Yes |
| 13 | LDHD | LDHD Entrez, Source | lactate dehydrogenase D | 2160 | 0.089 | 0.6156 | No |
| 14 | MDH2 | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 2409 | 0.082 | 0.6178 | No |
| 15 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 3142 | 0.063 | 0.5789 | No |
| 16 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 3614 | 0.053 | 0.5571 | No |
| 17 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 4819 | 0.032 | 0.4748 | No |
| 18 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 5218 | 0.026 | 0.4515 | No |
| 19 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 5797 | 0.017 | 0.4125 | No |
| 20 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 6026 | 0.014 | 0.3989 | No |
| 21 | GLO1 | GLO1 Entrez, Source | glyoxalase I | 6031 | 0.014 | 0.4021 | No |
| 22 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6175 | 0.012 | 0.3943 | No |
| 23 | LDHC | LDHC Entrez, Source | lactate dehydrogenase C | 6640 | 0.005 | 0.3607 | No |
| 24 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 7676 | -0.010 | 0.2855 | No |
| 25 | LDHAL6B | LDHAL6B Entrez, Source | lactate dehydrogenase A-like 6B | 8335 | -0.020 | 0.2413 | No |
| 26 | HAGHL | HAGHL Entrez, Source | hydroxyacylglutathione hydrolase-like | 8605 | -0.025 | 0.2273 | No |
| 27 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 9824 | -0.048 | 0.1481 | No |
| 28 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10674 | -0.069 | 0.1018 | No |
| 29 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 10995 | -0.078 | 0.0977 | No |
| 30 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 13034 | -0.309 | 0.0231 | No |
