Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | HSA04510_FOCAL_ADHESION |
| Enrichment Score (ES) | -0.5621904 |
| Normalized Enrichment Score (NES) | -2.0264568 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004286852 |
| FWER p-Value | 0.098 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL5A3 | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 224 | 0.297 | 0.0029 | No |
| 2 | VTN | VTN Entrez, Source | vitronectin | 349 | 0.249 | 0.0102 | No |
| 3 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 1001 | 0.144 | -0.0294 | No |
| 4 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 1014 | 0.144 | -0.0207 | No |
| 5 | TNR | TNR Entrez, Source | tenascin R (restrictin, janusin) | 1431 | 0.117 | -0.0444 | No |
| 6 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 1471 | 0.115 | -0.0397 | No |
| 7 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 1619 | 0.108 | -0.0436 | No |
| 8 | VAV1 | VAV1 Entrez, Source | vav 1 oncogene | 1642 | 0.107 | -0.0381 | No |
| 9 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1748 | 0.103 | -0.0392 | No |
| 10 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 1997 | 0.094 | -0.0516 | No |
| 11 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 2125 | 0.090 | -0.0552 | No |
| 12 | ARHGAP5 | ARHGAP5 Entrez, Source | Rho GTPase activating protein 5 | 2217 | 0.088 | -0.0562 | No |
| 13 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 2261 | 0.086 | -0.0537 | No |
| 14 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 2401 | 0.082 | -0.0587 | No |
| 15 | ITGA7 | ITGA7 Entrez, Source | integrin, alpha 7 | 2929 | 0.068 | -0.0941 | No |
| 16 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 2930 | 0.068 | -0.0895 | No |
| 17 | COL6A2 | COL6A2 Entrez, Source | collagen, type VI, alpha 2 | 2971 | 0.067 | -0.0880 | No |
| 18 | IGF1R | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 3241 | 0.061 | -0.1043 | No |
| 19 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 3361 | 0.059 | -0.1094 | No |
| 20 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 3374 | 0.059 | -0.1063 | No |
| 21 | MYL2 | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 3684 | 0.052 | -0.1262 | No |
| 22 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3781 | 0.050 | -0.1302 | No |
| 23 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 3941 | 0.048 | -0.1390 | No |
| 24 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 3999 | 0.046 | -0.1402 | No |
| 25 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 4079 | 0.045 | -0.1432 | No |
| 26 | PAK3 | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 4254 | 0.042 | -0.1536 | No |
| 27 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 4327 | 0.041 | -0.1563 | No |
| 28 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 4358 | 0.040 | -0.1559 | No |
| 29 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 4490 | 0.038 | -0.1633 | No |
| 30 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 4760 | 0.033 | -0.1814 | No |
| 31 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4923 | 0.030 | -0.1916 | No |
| 32 | COL2A1 | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 5191 | 0.026 | -0.2101 | No |
| 33 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 5266 | 0.025 | -0.2140 | No |
| 34 | ITGA1 | ITGA1 Entrez, Source | integrin, alpha 1 | 5518 | 0.021 | -0.2315 | No |
| 35 | CAV3 | CAV3 Entrez, Source | caveolin 3 | 5635 | 0.020 | -0.2390 | No |
| 36 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5720 | 0.018 | -0.2441 | No |
| 37 | RAP1A | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 5896 | 0.016 | -0.2563 | No |
| 38 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 6072 | 0.013 | -0.2687 | No |
| 39 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 6191 | 0.011 | -0.2768 | No |
| 40 | PARVA | PARVA Entrez, Source | parvin, alpha | 6285 | 0.010 | -0.2832 | No |
| 41 | PDGFD | PDGFD Entrez, Source | platelet derived growth factor D | 6307 | 0.009 | -0.2842 | No |
| 42 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6361 | 0.009 | -0.2876 | No |
| 43 | MYLK2 | MYLK2 Entrez, Source | myosin light chain kinase 2, skeletal muscle | 6497 | 0.006 | -0.2974 | No |
| 44 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 6709 | 0.004 | -0.3131 | No |
| 45 | IBSP | IBSP Entrez, Source | integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | 6712 | 0.004 | -0.3130 | No |
| 46 | THBS4 | THBS4 Entrez, Source | thrombospondin 4 | 6884 | 0.002 | -0.3259 | No |
| 47 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 7132 | -0.002 | -0.3444 | No |
| 48 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 7143 | -0.002 | -0.3450 | No |
| 49 | VWF | VWF Entrez, Source | von Willebrand factor | 7187 | -0.003 | -0.3481 | No |
| 50 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 7411 | -0.006 | -0.3646 | No |
| 51 | CRKL | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 7585 | -0.009 | -0.3771 | No |
| 52 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 8051 | -0.016 | -0.4112 | No |
| 53 | COL11A1 | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 8104 | -0.016 | -0.4141 | No |
| 54 | PPP1CC | PPP1CC Entrez, Source | protein phosphatase 1, catalytic subunit, gamma isoform | 8221 | -0.018 | -0.4216 | No |
| 55 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 8308 | -0.020 | -0.4268 | No |
| 56 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8312 | -0.020 | -0.4257 | No |
| 57 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8414 | -0.022 | -0.4319 | No |
| 58 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 8798 | -0.028 | -0.4590 | No |
| 59 | PPP1CB | PPP1CB Entrez, Source | protein phosphatase 1, catalytic subunit, beta isoform | 8852 | -0.029 | -0.4611 | No |
| 60 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 8861 | -0.029 | -0.4597 | No |
| 61 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 8887 | -0.030 | -0.4596 | No |
| 62 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 8955 | -0.031 | -0.4626 | No |
| 63 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 9131 | -0.035 | -0.4735 | No |
| 64 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9287 | -0.038 | -0.4827 | No |
| 65 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 9335 | -0.038 | -0.4837 | No |
| 66 | PDGFRB | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 9380 | -0.039 | -0.4844 | No |
| 67 | PDGFRA | PDGFRA Entrez, Source | platelet-derived growth factor receptor, alpha polypeptide | 9383 | -0.039 | -0.4820 | No |
| 68 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9430 | -0.040 | -0.4827 | No |
| 69 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 9556 | -0.043 | -0.4893 | No |
| 70 | FIGF | FIGF Entrez, Source | c-fos induced growth factor (vascular endothelial growth factor D) | 9686 | -0.045 | -0.4961 | No |
| 71 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 9755 | -0.047 | -0.4981 | No |
| 72 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9776 | -0.047 | -0.4964 | No |
| 73 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 9869 | -0.049 | -0.5001 | No |
| 74 | CHAD | CHAD Entrez, Source | chondroadherin | 9871 | -0.049 | -0.4969 | No |
| 75 | FN1 | FN1 Entrez, Source | fibronectin 1 | 10062 | -0.053 | -0.5077 | No |
| 76 | PPP1CA | PPP1CA Entrez, Source | protein phosphatase 1, catalytic subunit, alpha isoform | 10210 | -0.057 | -0.5151 | No |
| 77 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10634 | -0.068 | -0.5425 | No |
| 78 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10733 | -0.071 | -0.5452 | No |
| 79 | ITGB7 | ITGB7 Entrez, Source | integrin, beta 7 | 10842 | -0.074 | -0.5485 | No |
| 80 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 10962 | -0.077 | -0.5523 | No |
| 81 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 11000 | -0.079 | -0.5498 | No |
| 82 | RAPGEF1 | RAPGEF1 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 1 | 11097 | -0.082 | -0.5516 | No |
| 83 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 11231 | -0.087 | -0.5559 | Yes |
| 84 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 11293 | -0.090 | -0.5545 | Yes |
| 85 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 11396 | -0.095 | -0.5559 | Yes |
| 86 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11466 | -0.098 | -0.5545 | Yes |
| 87 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 11474 | -0.098 | -0.5485 | Yes |
| 88 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 11494 | -0.099 | -0.5433 | Yes |
| 89 | ACTB | ACTB Entrez, Source | actin, beta | 11552 | -0.102 | -0.5408 | Yes |
| 90 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 11622 | -0.106 | -0.5389 | Yes |
| 91 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 11637 | -0.106 | -0.5329 | Yes |
| 92 | KDR | KDR Entrez, Source | kinase insert domain receptor (a type III receptor tyrosine kinase) | 11669 | -0.108 | -0.5280 | Yes |
| 93 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 11708 | -0.110 | -0.5236 | Yes |
| 94 | JUN | JUN Entrez, Source | jun oncogene | 11756 | -0.111 | -0.5197 | Yes |
| 95 | ITGA9 | ITGA9 Entrez, Source | integrin, alpha 9 | 11796 | -0.113 | -0.5150 | Yes |
| 96 | COMP | COMP Entrez, Source | cartilage oligomeric matrix protein | 11817 | -0.115 | -0.5089 | Yes |
| 97 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11904 | -0.119 | -0.5075 | Yes |
| 98 | CAPN2 | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 11927 | -0.120 | -0.5011 | Yes |
| 99 | ACTN3 | ACTN3 Entrez, Source | actinin, alpha 3 | 11968 | -0.123 | -0.4959 | Yes |
| 100 | COL5A2 | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 12008 | -0.126 | -0.4905 | Yes |
| 101 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 12011 | -0.126 | -0.4822 | Yes |
| 102 | TLN1 | TLN1 Entrez, Source | talin 1 | 12039 | -0.127 | -0.4757 | Yes |
| 103 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 12148 | -0.134 | -0.4749 | Yes |
| 104 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 12233 | -0.142 | -0.4718 | Yes |
| 105 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 12348 | -0.153 | -0.4702 | Yes |
| 106 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 12355 | -0.153 | -0.4604 | Yes |
| 107 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12441 | -0.162 | -0.4559 | Yes |
| 108 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12449 | -0.164 | -0.4455 | Yes |
| 109 | ILK | ILK Entrez, Source | integrin-linked kinase | 12453 | -0.164 | -0.4347 | Yes |
| 110 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12536 | -0.176 | -0.4291 | Yes |
| 111 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12541 | -0.177 | -0.4176 | Yes |
| 112 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 12592 | -0.184 | -0.4091 | Yes |
| 113 | CAV2 | CAV2 Entrez, Source | caveolin 2 | 12694 | -0.203 | -0.4031 | Yes |
| 114 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12697 | -0.204 | -0.3896 | Yes |
| 115 | PXN | PXN Entrez, Source | paxillin | 12740 | -0.211 | -0.3787 | Yes |
| 116 | PIP5K1C | PIP5K1C Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 12776 | -0.218 | -0.3667 | Yes |
| 117 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12855 | -0.239 | -0.3567 | Yes |
| 118 | ACTN4 | ACTN4 Entrez, Source | actinin, alpha 4 | 12871 | -0.243 | -0.3415 | Yes |
| 119 | ZYX | ZYX Entrez, Source | zyxin | 12928 | -0.262 | -0.3283 | Yes |
| 120 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 12937 | -0.264 | -0.3112 | Yes |
| 121 | RELN | RELN Entrez, Source | reelin | 12968 | -0.279 | -0.2948 | Yes |
| 122 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13018 | -0.300 | -0.2785 | Yes |
| 123 | ROCK2 | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 13035 | -0.310 | -0.2589 | Yes |
| 124 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13080 | -0.340 | -0.2395 | Yes |
| 125 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13085 | -0.343 | -0.2169 | Yes |
| 126 | PDGFA | PDGFA Entrez, Source | platelet-derived growth factor alpha polypeptide | 13176 | -0.433 | -0.1947 | Yes |
| 127 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 13195 | -0.458 | -0.1654 | Yes |
| 128 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13264 | -0.594 | -0.1308 | Yes |
| 129 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 13273 | -0.645 | -0.0883 | Yes |
| 130 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13279 | -0.655 | -0.0448 | Yes |
| 131 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13299 | -0.740 | 0.0033 | Yes |
