Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | HSA04530_TIGHT_JUNCTION |
| Enrichment Score (ES) | -0.5309538 |
| Normalized Enrichment Score (NES) | -1.7950215 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.038033698 |
| FWER p-Value | 0.979 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CLDN14 | CLDN14 Entrez, Source | claudin 14 | 306 | 0.265 | 0.0053 | No |
| 2 | MYH14 | MYH14 Entrez, Source | myosin, heavy chain 14 | 634 | 0.182 | 0.0002 | No |
| 3 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 1352 | 0.121 | -0.0408 | No |
| 4 | MYH13 | MYH13 Entrez, Source | myosin, heavy chain 13, skeletal muscle | 1490 | 0.114 | -0.0389 | No |
| 5 | PPM1J | PPM1J Entrez, Source | protein phosphatase 1J (PP2C domain containing) | 1502 | 0.113 | -0.0276 | No |
| 6 | CLDN11 | CLDN11 Entrez, Source | claudin 11 (oligodendrocyte transmembrane protein) | 1925 | 0.096 | -0.0491 | No |
| 7 | CLDN8 | CLDN8 Entrez, Source | claudin 8 | 2374 | 0.083 | -0.0739 | No |
| 8 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 2401 | 0.082 | -0.0670 | No |
| 9 | CSDA | CSDA Entrez, Source | cold shock domain protein A | 2927 | 0.068 | -0.0993 | No |
| 10 | MYH2 | MYH2 Entrez, Source | myosin, heavy chain 2, skeletal muscle, adult | 2937 | 0.068 | -0.0927 | No |
| 11 | CRB3 | CRB3 Entrez, Source | crumbs homolog 3 (Drosophila) | 3038 | 0.066 | -0.0931 | No |
| 12 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 3361 | 0.059 | -0.1111 | No |
| 13 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 3644 | 0.053 | -0.1267 | No |
| 14 | MYL2 | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 3684 | 0.052 | -0.1240 | No |
| 15 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 3815 | 0.050 | -0.1285 | No |
| 16 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 3999 | 0.046 | -0.1373 | No |
| 17 | PRKCZ | PRKCZ Entrez, Source | protein kinase C, zeta | 4083 | 0.045 | -0.1388 | No |
| 18 | CSNK2B | CSNK2B Entrez, Source | casein kinase 2, beta polypeptide | 4466 | 0.038 | -0.1634 | No |
| 19 | PRKCH | PRKCH Entrez, Source | protein kinase C, eta | 4516 | 0.038 | -0.1631 | No |
| 20 | VAPA | VAPA Entrez, Source | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 4659 | 0.035 | -0.1701 | No |
| 21 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4923 | 0.030 | -0.1866 | No |
| 22 | MYH1 | MYH1 Entrez, Source | myosin, heavy chain 1, skeletal muscle, adult | 5171 | 0.027 | -0.2024 | No |
| 23 | PARD6A | PARD6A Entrez, Source | par-6 partitioning defective 6 homolog alpha (C.elegans) | 5506 | 0.022 | -0.2253 | No |
| 24 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5720 | 0.018 | -0.2393 | No |
| 25 | JAM2 | JAM2 Entrez, Source | junctional adhesion molecule 2 | 6160 | 0.012 | -0.2712 | No |
| 26 | HCLS1 | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 6405 | 0.008 | -0.2887 | No |
| 27 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 6721 | 0.004 | -0.3121 | No |
| 28 | MYH8 | MYH8 Entrez, Source | myosin, heavy chain 8, skeletal muscle, perinatal | 6915 | 0.001 | -0.3266 | No |
| 29 | CLDN16 | CLDN16 Entrez, Source | claudin 16 | 7371 | -0.006 | -0.3603 | No |
| 30 | PRKCE | PRKCE Entrez, Source | protein kinase C, epsilon | 8304 | -0.020 | -0.4284 | No |
| 31 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8312 | -0.020 | -0.4268 | No |
| 32 | EXOC3 | EXOC3 Entrez, Source | exocyst complex component 3 | 8409 | -0.022 | -0.4317 | No |
| 33 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 8532 | -0.024 | -0.4384 | No |
| 34 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 8665 | -0.026 | -0.4456 | No |
| 35 | MYH3 | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 8743 | -0.027 | -0.4485 | No |
| 36 | SYMPK | SYMPK Entrez, Source | symplekin | 8892 | -0.030 | -0.4564 | No |
| 37 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 9131 | -0.035 | -0.4707 | No |
| 38 | GNAI3 | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 9496 | -0.042 | -0.4937 | No |
| 39 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 9556 | -0.043 | -0.4935 | No |
| 40 | PPP2R1A | PPP2R1A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 9862 | -0.049 | -0.5113 | No |
| 41 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9882 | -0.049 | -0.5074 | No |
| 42 | PPP2CA | PPP2CA Entrez, Source | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 9927 | -0.051 | -0.5053 | No |
| 43 | MAGI2 | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 9967 | -0.051 | -0.5027 | No |
| 44 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 10094 | -0.054 | -0.5064 | No |
| 45 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 10349 | -0.060 | -0.5190 | No |
| 46 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 10487 | -0.064 | -0.5225 | No |
| 47 | CLDN5 | CLDN5 Entrez, Source | claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) | 10600 | -0.067 | -0.5238 | Yes |
| 48 | MYH4 | MYH4 Entrez, Source | myosin, heavy chain 4, skeletal muscle | 10619 | -0.067 | -0.5179 | Yes |
| 49 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10634 | -0.068 | -0.5117 | Yes |
| 50 | PARD3 | PARD3 Entrez, Source | par-3 partitioning defective 3 homolog (C. elegans) | 10642 | -0.068 | -0.5049 | Yes |
| 51 | PPP2R2A | PPP2R2A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform | 10720 | -0.070 | -0.5031 | Yes |
| 52 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 10994 | -0.078 | -0.5153 | Yes |
| 53 | PPP2CB | PPP2CB Entrez, Source | protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | 11093 | -0.082 | -0.5139 | Yes |
| 54 | MAGI3 | MAGI3 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 11184 | -0.085 | -0.5116 | Yes |
| 55 | CLDN19 | CLDN19 Entrez, Source | claudin 19 | 11250 | -0.088 | -0.5070 | Yes |
| 56 | F11R | F11R Entrez, Source | F11 receptor | 11299 | -0.090 | -0.5009 | Yes |
| 57 | MLLT4 | MLLT4 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 11397 | -0.095 | -0.4981 | Yes |
| 58 | PPP2R1B | PPP2R1B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | 11399 | -0.095 | -0.4880 | Yes |
| 59 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11466 | -0.098 | -0.4824 | Yes |
| 60 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 11494 | -0.099 | -0.4738 | Yes |
| 61 | ACTB | ACTB Entrez, Source | actin, beta | 11552 | -0.102 | -0.4671 | Yes |
| 62 | PPP2R2C | PPP2R2C Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform | 11700 | -0.109 | -0.4665 | Yes |
| 63 | PPP2R2B | PPP2R2B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform | 11938 | -0.121 | -0.4714 | Yes |
| 64 | CTTN | CTTN Entrez, Source | cortactin | 11952 | -0.122 | -0.4593 | Yes |
| 65 | ACTN3 | ACTN3 Entrez, Source | actinin, alpha 3 | 11968 | -0.123 | -0.4472 | Yes |
| 66 | EXOC4 | EXOC4 Entrez, Source | exocyst complex component 4 | 11969 | -0.123 | -0.4340 | Yes |
| 67 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12113 | -0.132 | -0.4306 | Yes |
| 68 | CASK | CASK Entrez, Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 12154 | -0.135 | -0.4191 | Yes |
| 69 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 12254 | -0.144 | -0.4111 | Yes |
| 70 | RAB13 | RAB13 Entrez, Source | RAB13, member RAS oncogene family | 12265 | -0.145 | -0.3963 | Yes |
| 71 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12272 | -0.146 | -0.3811 | Yes |
| 72 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12456 | -0.165 | -0.3772 | Yes |
| 73 | GNAI2 | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 12486 | -0.168 | -0.3613 | Yes |
| 74 | TJP2 | TJP2 Entrez, Source | tight junction protein 2 (zona occludens 2) | 12531 | -0.176 | -0.3458 | Yes |
| 75 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 12546 | -0.178 | -0.3277 | Yes |
| 76 | PRKCI | PRKCI Entrez, Source | protein kinase C, iota | 12716 | -0.208 | -0.3181 | Yes |
| 77 | MPDZ | MPDZ Entrez, Source | multiple PDZ domain protein | 12723 | -0.209 | -0.2961 | Yes |
| 78 | ACTN4 | ACTN4 Entrez, Source | actinin, alpha 4 | 12871 | -0.243 | -0.2811 | Yes |
| 79 | JAM3 | JAM3 Entrez, Source | junctional adhesion molecule 3 | 12925 | -0.260 | -0.2571 | Yes |
| 80 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 12969 | -0.279 | -0.2304 | Yes |
| 81 | RRAS2 | RRAS2 Entrez, Source | related RAS viral (r-ras) oncogene homolog 2 | 13055 | -0.322 | -0.2023 | Yes |
| 82 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13262 | -0.580 | -0.1555 | Yes |
| 83 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13279 | -0.655 | -0.0863 | Yes |
| 84 | PPP2R3A | PPP2R3A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha | 13312 | -0.847 | 0.0023 | Yes |
