Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | 0.5333923 |
| Normalized Enrichment Score (NES) | 1.8217983 |
| Nominal p-value | 0.0025575447 |
| FDR q-value | 0.012683585 |
| FWER p-Value | 0.807 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | KLKB1 | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 29 | 0.564 | 0.0547 | Yes |
| 2 | C4BPB | C4BPB Entrez, Source | complement component 4 binding protein, beta | 65 | 0.477 | 0.1003 | Yes |
| 3 | PLG | PLG Entrez, Source | plasminogen | 81 | 0.434 | 0.1430 | Yes |
| 4 | SERPIND1 | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 92 | 0.424 | 0.1850 | Yes |
| 5 | CFB | CFB Entrez, Source | complement factor B | 107 | 0.413 | 0.2257 | Yes |
| 6 | C4BPA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 176 | 0.331 | 0.2539 | Yes |
| 7 | C6 | C6 Entrez, Source | complement component 6 | 247 | 0.288 | 0.2777 | Yes |
| 8 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 253 | 0.286 | 0.3063 | Yes |
| 9 | F9 | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 289 | 0.270 | 0.3310 | Yes |
| 10 | SERPINA5 | SERPINA5 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 305 | 0.265 | 0.3566 | Yes |
| 11 | F10 | F10 Entrez, Source | coagulation factor X | 342 | 0.251 | 0.3792 | Yes |
| 12 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 383 | 0.238 | 0.4003 | Yes |
| 13 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 518 | 0.198 | 0.4102 | Yes |
| 14 | C9 | C9 Entrez, Source | complement component 9 | 571 | 0.189 | 0.4254 | Yes |
| 15 | SERPINF2 | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 607 | 0.185 | 0.4415 | Yes |
| 16 | SERPINC1 | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 690 | 0.175 | 0.4530 | Yes |
| 17 | MASP2 | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 718 | 0.171 | 0.4682 | Yes |
| 18 | PROC | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 739 | 0.168 | 0.4837 | Yes |
| 19 | FGB | FGB Entrez, Source | fibrinogen beta chain | 1040 | 0.141 | 0.4754 | Yes |
| 20 | THBD | THBD Entrez, Source | thrombomodulin | 1055 | 0.140 | 0.4885 | Yes |
| 21 | CFD | CFD Entrez, Source | complement factor D (adipsin) | 1087 | 0.138 | 0.5001 | Yes |
| 22 | MBL2 | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 1090 | 0.138 | 0.5138 | Yes |
| 23 | CFI | CFI Entrez, Source | complement factor I | 1261 | 0.126 | 0.5138 | Yes |
| 24 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1340 | 0.122 | 0.5203 | Yes |
| 25 | FGA | FGA Entrez, Source | fibrinogen alpha chain | 1474 | 0.115 | 0.5218 | Yes |
| 26 | C3 | C3 Entrez, Source | complement component 3 | 1475 | 0.114 | 0.5334 | Yes |
| 27 | F12 | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 1808 | 0.101 | 0.5186 | No |
| 28 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 2208 | 0.088 | 0.4975 | No |
| 29 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 2296 | 0.085 | 0.4995 | No |
| 30 | F2 | F2 Entrez, Source | coagulation factor II (thrombin) | 2335 | 0.084 | 0.5051 | No |
| 31 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 2545 | 0.078 | 0.4973 | No |
| 32 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3307 | 0.060 | 0.4461 | No |
| 33 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 3405 | 0.058 | 0.4447 | No |
| 34 | CPB2 | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 4145 | 0.044 | 0.3935 | No |
| 35 | CFH | CFH Entrez, Source | complement factor H | 4536 | 0.037 | 0.3679 | No |
| 36 | A2M | A2M Entrez, Source | alpha-2-macroglobulin | 5584 | 0.021 | 0.2912 | No |
| 37 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 5599 | 0.020 | 0.2922 | No |
| 38 | F8 | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 5850 | 0.017 | 0.2751 | No |
| 39 | PROS1 | PROS1 Entrez, Source | protein S (alpha) | 6244 | 0.011 | 0.2466 | No |
| 40 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 6332 | 0.009 | 0.2410 | No |
| 41 | VWF | VWF Entrez, Source | von Willebrand factor | 7187 | -0.003 | 0.1770 | No |
| 42 | F13A1 | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 8934 | -0.031 | 0.0487 | No |
| 43 | MASP1 | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 9195 | -0.035 | 0.0328 | No |
| 44 | BDKRB1 | BDKRB1 Entrez, Source | bradykinin receptor B1 | 9477 | -0.041 | 0.0158 | No |
| 45 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 10498 | -0.064 | -0.0545 | No |
| 46 | C2 | C2 Entrez, Source | complement component 2 | 11048 | -0.080 | -0.0877 | No |
| 47 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 11480 | -0.099 | -0.1101 | No |
| 48 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 12491 | -0.169 | -0.1691 | No |
| 49 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13125 | -0.378 | -0.1785 | No |
| 50 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13198 | -0.463 | -0.1372 | No |
| 51 | F2R | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 13282 | -0.665 | -0.0763 | No |
| 52 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13308 | -0.800 | 0.0026 | No |
