Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | HSA05211_RENAL_CELL_CARCINOMA |
| Enrichment Score (ES) | -0.5378905 |
| Normalized Enrichment Score (NES) | -1.7052726 |
| Nominal p-value | 0.0034722222 |
| FDR q-value | 0.061536614 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 986 | 0.146 | -0.0421 | No |
| 2 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 2125 | 0.090 | -0.1080 | No |
| 3 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 2628 | 0.076 | -0.1292 | No |
| 4 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 3361 | 0.059 | -0.1713 | No |
| 5 | ARNT | ARNT Entrez, Source | aryl hydrocarbon receptor nuclear translocator | 3368 | 0.059 | -0.1589 | No |
| 6 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 3591 | 0.054 | -0.1638 | No |
| 7 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 3941 | 0.048 | -0.1796 | No |
| 8 | PAK3 | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 4254 | 0.042 | -0.1938 | No |
| 9 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 4760 | 0.033 | -0.2246 | No |
| 10 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4923 | 0.030 | -0.2301 | No |
| 11 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 5266 | 0.025 | -0.2503 | No |
| 12 | ARNT2 | ARNT2 Entrez, Source | aryl-hydrocarbon receptor nuclear translocator 2 | 5871 | 0.016 | -0.2922 | No |
| 13 | RAP1A | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 5896 | 0.016 | -0.2906 | No |
| 14 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 6072 | 0.013 | -0.3008 | No |
| 15 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 6191 | 0.011 | -0.3072 | No |
| 16 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6361 | 0.009 | -0.3181 | No |
| 17 | TCEB1 | TCEB1 Entrez, Source | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | 7156 | -0.002 | -0.3773 | No |
| 18 | TCEB2 | TCEB2 Entrez, Source | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) | 7503 | -0.008 | -0.4017 | No |
| 19 | CRKL | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 7585 | -0.009 | -0.4059 | No |
| 20 | EGLN1 | EGLN1 Entrez, Source | egl nine homolog 1 (C. elegans) | 8000 | -0.015 | -0.4337 | No |
| 21 | MAP2K2 | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 8062 | -0.016 | -0.4349 | No |
| 22 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 8096 | -0.016 | -0.4338 | No |
| 23 | RBX1 | RBX1 Entrez, Source | ring-box 1 | 8219 | -0.018 | -0.4390 | No |
| 24 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8414 | -0.022 | -0.4488 | No |
| 25 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 8561 | -0.024 | -0.4545 | No |
| 26 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 8955 | -0.031 | -0.4772 | No |
| 27 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 9131 | -0.035 | -0.4828 | No |
| 28 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9287 | -0.038 | -0.4862 | No |
| 29 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9430 | -0.040 | -0.4881 | No |
| 30 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 9556 | -0.043 | -0.4881 | No |
| 31 | FIGF | FIGF Entrez, Source | c-fos induced growth factor (vascular endothelial growth factor D) | 9686 | -0.045 | -0.4879 | No |
| 32 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 9755 | -0.047 | -0.4827 | No |
| 33 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9882 | -0.049 | -0.4814 | No |
| 34 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10634 | -0.068 | -0.5230 | Yes |
| 35 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10733 | -0.071 | -0.5149 | Yes |
| 36 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 10788 | -0.072 | -0.5031 | Yes |
| 37 | FLCN | FLCN Entrez, Source | folliculin | 10924 | -0.076 | -0.4965 | Yes |
| 38 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 10962 | -0.077 | -0.4823 | Yes |
| 39 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 11000 | -0.079 | -0.4679 | Yes |
| 40 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 11002 | -0.079 | -0.4507 | Yes |
| 41 | RAPGEF1 | RAPGEF1 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 1 | 11097 | -0.082 | -0.4398 | Yes |
| 42 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 11293 | -0.090 | -0.4347 | Yes |
| 43 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 11622 | -0.106 | -0.4363 | Yes |
| 44 | JUN | JUN Entrez, Source | jun oncogene | 11756 | -0.111 | -0.4218 | Yes |
| 45 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 12112 | -0.132 | -0.4196 | Yes |
| 46 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12113 | -0.132 | -0.3906 | Yes |
| 47 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 12148 | -0.134 | -0.3638 | Yes |
| 48 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12441 | -0.162 | -0.3501 | Yes |
| 49 | VHL | VHL Entrez, Source | von Hippel-Lindau tumor suppressor | 12446 | -0.164 | -0.3145 | Yes |
| 50 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12449 | -0.164 | -0.2788 | Yes |
| 51 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 12528 | -0.175 | -0.2462 | Yes |
| 52 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12536 | -0.176 | -0.2080 | Yes |
| 53 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12697 | -0.204 | -0.1752 | Yes |
| 54 | ETS1 | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 12930 | -0.262 | -0.1352 | Yes |
| 55 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 12962 | -0.277 | -0.0768 | Yes |
| 56 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13210 | -0.480 | 0.0099 | Yes |
