Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | HSA05222_SMALL_CELL_LUNG_CANCER |
| Enrichment Score (ES) | -0.54196787 |
| Normalized Enrichment Score (NES) | -1.740005 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.049795218 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RARB | RARB Entrez, Source | retinoic acid receptor, beta | 214 | 0.304 | 0.0250 | No |
| 2 | RXRG | RXRG Entrez, Source | retinoid X receptor, gamma | 499 | 0.203 | 0.0310 | No |
| 3 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 566 | 0.190 | 0.0517 | No |
| 4 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 1001 | 0.144 | 0.0386 | No |
| 5 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1609 | 0.108 | 0.0076 | No |
| 6 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 1781 | 0.102 | 0.0085 | No |
| 7 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 2241 | 0.087 | -0.0144 | No |
| 8 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 2560 | 0.078 | -0.0278 | No |
| 9 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2746 | 0.073 | -0.0319 | No |
| 10 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2765 | 0.072 | -0.0235 | No |
| 11 | NOS1 | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 2908 | 0.069 | -0.0249 | No |
| 12 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 3361 | 0.059 | -0.0510 | No |
| 13 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 4358 | 0.040 | -0.1205 | No |
| 14 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 4760 | 0.033 | -0.1462 | No |
| 15 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 5011 | 0.029 | -0.1611 | No |
| 16 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5720 | 0.018 | -0.2119 | No |
| 17 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.2432 | No |
| 18 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6361 | 0.009 | -0.2572 | No |
| 19 | PIAS2 | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 6672 | 0.004 | -0.2800 | No |
| 20 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6707 | 0.004 | -0.2820 | No |
| 21 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 6861 | 0.002 | -0.2933 | No |
| 22 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 8044 | -0.015 | -0.3802 | No |
| 23 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8216 | -0.018 | -0.3906 | No |
| 24 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8414 | -0.022 | -0.4025 | No |
| 25 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 8887 | -0.030 | -0.4340 | No |
| 26 | RXRB | RXRB Entrez, Source | retinoid X receptor, beta | 9083 | -0.034 | -0.4441 | No |
| 27 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 9131 | -0.035 | -0.4430 | No |
| 28 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 9335 | -0.038 | -0.4531 | No |
| 29 | PIAS4 | PIAS4 Entrez, Source | protein inhibitor of activated STAT, 4 | 9683 | -0.045 | -0.4731 | No |
| 30 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9776 | -0.047 | -0.4736 | No |
| 31 | FN1 | FN1 Entrez, Source | fibronectin 1 | 10062 | -0.053 | -0.4879 | No |
| 32 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 10137 | -0.055 | -0.4860 | No |
| 33 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10634 | -0.068 | -0.5141 | No |
| 34 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 10726 | -0.071 | -0.5115 | No |
| 35 | FHIT | FHIT Entrez, Source | fragile histidine triad gene | 10806 | -0.073 | -0.5076 | No |
| 36 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 10828 | -0.073 | -0.4993 | No |
| 37 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 11396 | -0.095 | -0.5292 | Yes |
| 38 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 11490 | -0.099 | -0.5228 | Yes |
| 39 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 11622 | -0.106 | -0.5184 | Yes |
| 40 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 11637 | -0.106 | -0.5051 | Yes |
| 41 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11886 | -0.118 | -0.5078 | Yes |
| 42 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11904 | -0.119 | -0.4931 | Yes |
| 43 | MAX | MAX Entrez, Source | MYC associated factor X | 11963 | -0.122 | -0.4809 | Yes |
| 44 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12272 | -0.146 | -0.4844 | Yes |
| 45 | PIAS3 | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 12362 | -0.154 | -0.4703 | Yes |
| 46 | NOS3 | NOS3 Entrez, Source | nitric oxide synthase 3 (endothelial cell) | 12369 | -0.155 | -0.4498 | Yes |
| 47 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.4293 | Yes |
| 48 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12536 | -0.176 | -0.4174 | Yes |
| 49 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 12592 | -0.184 | -0.3967 | Yes |
| 50 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12855 | -0.239 | -0.3842 | Yes |
| 51 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 12937 | -0.264 | -0.3545 | Yes |
| 52 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13018 | -0.300 | -0.3200 | Yes |
| 53 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13085 | -0.343 | -0.2787 | Yes |
| 54 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13156 | -0.411 | -0.2285 | Yes |
| 55 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 13195 | -0.458 | -0.1695 | Yes |
| 56 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13264 | -0.594 | -0.0943 | Yes |
| 57 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13299 | -0.740 | 0.0032 | Yes |
