Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_72h_versus_single_gel_72h.class.cls
#double_gel_72h_versus_single_gel_72h_repos
Phenotypeclass.cls#double_gel_72h_versus_single_gel_72h_repos
Upregulated in classdouble_gel_72h
GeneSetHSIAO_LIVER_SPECIFIC_GENES
Enrichment Score (ES)0.7119267
Normalized Enrichment Score (NES)2.9514976
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HSIAO_LIVER_SPECIFIC_GENES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver21.1120.0300Yes
2SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 140.9240.0549Yes
3AADACAADAC
Entrez,  Source
arylacetamide deacetylase (esterase)110.7580.0750Yes
4HRGHRG
Entrez,  Source
histidine-rich glycoprotein120.7470.0952Yes
5APOA2APOA2
Entrez,  Source
apolipoprotein A-II220.6010.1108Yes
6KLKB1KLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 1290.5640.1256Yes
7GSTA2GSTA2
Entrez,  Source
glutathione S-transferase A2390.5270.1392Yes
8FBP1FBP1
Entrez,  Source
fructose-1,6-bisphosphatase 1430.5150.1529Yes
9OTCOTC
Entrez,  Source
ornithine carbamoyltransferase440.5060.1666Yes
10TFTF
Entrez,  Source
transferrin480.5020.1800Yes
11CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I580.4840.1924Yes
12ASGR2ASGR2
Entrez,  Source
asialoglycoprotein receptor 2800.4340.2026Yes
13PLGPLG
Entrez,  Source
plasminogen810.4340.2143Yes
14DPYSDPYS
Entrez,  Source
dihydropyrimidinase900.4250.2252Yes
15SERPIND1SERPIND1
Entrez,  Source
serpin peptidase inhibitor, clade D (heparin cofactor), member 1920.4240.2366Yes
16ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain950.4190.2478Yes
17NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 21040.4160.2585Yes
18BHMTBHMT
Entrez,  Source
betaine-homocysteine methyltransferase1060.4150.2696Yes
19CFBCFB
Entrez,  Source
complement factor B1070.4130.2808Yes
20HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)1170.3960.2909Yes
21CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)1180.3940.3015Yes
22HGDHGD
Entrez,  Source
homogentisate 1,2-dioxygenase (homogentisate oxidase)1260.3850.3114Yes
23APOC1APOC1
Entrez,  Source
apolipoprotein C-I1270.3840.3218Yes
24AGXTAGXT
Entrez,  Source
alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)1280.3840.3322Yes
25G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit1290.3830.3426Yes
26ACAA2ACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)1350.3740.3524Yes
27LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase1420.3650.3618Yes
28ACAT2ACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)1440.3620.3715Yes
29ARG1ARG1
Entrez,  Source
arginase, liver1450.3580.3812Yes
30SERPINA7SERPINA7
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 71620.3430.3893Yes
31C4BPAC4BPA
Entrez,  Source
complement component 4 binding protein, alpha1760.3310.3973Yes
32ASLASL
Entrez,  Source
argininosuccinate lyase1830.3230.4056Yes
33ASGR1ASGR1
Entrez,  Source
asialoglycoprotein receptor 11890.3190.4138Yes
34AOX1AOX1
Entrez,  Source
aldehyde oxidase 12010.3090.4214Yes
35MTTPMTTP
Entrez,  Source
microsomal triglyceride transfer protein2180.3010.4283Yes
36FAHFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)2190.2990.4364Yes
37FGL1FGL1
Entrez,  Source
fibrinogen-like 12230.2980.4442Yes
38RBP4RBP4
Entrez,  Source
retinol binding protein 4, plasma2290.2940.4518Yes
39GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)2430.2890.4586Yes
40NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 42460.2880.4663Yes
41GHRGHR
Entrez,  Source
growth hormone receptor2500.2870.4739Yes
42SERPINA4SERPINA4
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 42520.2870.4815Yes
43HPNHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)2540.2860.4892Yes
44CFHR1CFHR1
Entrez,  Source
complement factor H-related 12710.2780.4955Yes
45F9F9
Entrez,  Source
coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)2890.2700.5016Yes
46CATCAT
Entrez,  Source
catalase2900.2690.5088Yes
47CPS1CPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial2920.2680.5160Yes
48AZGP1AZGP1
Entrez,  Source
alpha-2-glycoprotein 1, zinc2930.2680.5233Yes
49CBSCBS
Entrez,  Source
cystathionine-beta-synthase2940.2670.5305Yes
50SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 53050.2650.5369Yes
51GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)3140.2630.5434Yes
52F10F10
Entrez,  Source
coagulation factor X3420.2510.5482Yes
53VTNVTN
Entrez,  Source
vitronectin3490.2490.5544Yes
54SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 33570.2450.5606Yes
55TDO2TDO2
Entrez,  Source
tryptophan 2,3-dioxygenase3580.2450.5672Yes
56HSD11B1HSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 13700.2420.5729Yes
57ABCC6ABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 63810.2390.5786Yes
58TSTTST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)3880.2350.5845Yes
59FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 44020.2300.5898Yes
60SEPHS2SEPHS2
Entrez,  Source
selenophosphate synthetase 24040.2300.5959Yes
61MTHFD1MTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase4050.2290.6022Yes
62CRPCRP
Entrez,  Source
C-reactive protein, pentraxin-related4110.2270.6079Yes
63ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 14190.2240.6135Yes
64HALHAL
Entrez,  Source
histidine ammonia-lyase4230.2240.6193Yes
65SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like4440.2180.6237Yes
66ALDH6A1ALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A14450.2170.6296Yes
67LBPLBP
Entrez,  Source
lipopolysaccharide binding protein4760.2090.6330Yes
68HRSP12HRSP12
Entrez,  Source
heat-responsive protein 125190.1980.6351Yes
69ACAT1ACAT1
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)5600.1910.6373Yes
70PCSK6PCSK6
Entrez,  Source
proprotein convertase subtilisin/kexin type 65670.1900.6420Yes
71BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)5970.1860.6448Yes
72SERPINF2SERPINF2
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 26070.1850.6491Yes
73ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 16090.1850.6541Yes
74TATTAT
Entrez,  Source
tyrosine aminotransferase6740.1760.6540Yes
75DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase6850.1750.6579Yes
76SERPINC1SERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 16900.1750.6624Yes
77KYNUKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)6950.1740.6668Yes
78IGFBP1IGFBP1
Entrez,  Source
insulin-like growth factor binding protein 17030.1730.6709Yes
79APOHAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)7260.1700.6738Yes
80PYGLPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)7280.1700.6784Yes
81HMGCLHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)7320.1690.6827Yes
82PROCPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)7390.1680.6868Yes
83PON3PON3
Entrez,  Source
paraoxonase 38610.1560.6819Yes
84LTB4DHLTB4DH
Entrez,  Source
leukotriene B4 12-hydroxydehydrogenase9310.1510.6807Yes
85CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 29330.1500.6847Yes
86SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)9390.1500.6883Yes
87ALDOBALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate10070.1440.6872Yes
88APOBAPOB
Entrez,  Source
apolipoprotein B (including Ag(x) antigen)10090.1440.6910Yes
89SAA4SAA4
Entrez,  Source
serum amyloid A4, constitutive10240.1430.6938Yes
90PORPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase10300.1420.6972Yes
91FGBFGB
Entrez,  Source
fibrinogen beta chain10400.1410.7004Yes
92DDTDDT
Entrez,  Source
D-dopachrome tautomerase10760.1390.7015Yes
93ACSM3ACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 310820.1380.7048Yes
94MBL2MBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)10900.1380.7080Yes
95AGTAGT
Entrez,  Source
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)12010.1300.7032Yes
96CFICFI
Entrez,  Source
complement factor I12610.1260.7021Yes
97GJB1GJB1
Entrez,  Source
gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)12930.1240.7031Yes
98PZPPZP
Entrez,  Source
pregnancy-zone protein13010.1240.7060Yes
99TFPITFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)13400.1220.7064Yes
100CYP2E1CYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 113690.1210.7075Yes
101ASS1ASS1
Entrez,  Source
argininosuccinate synthetase 113820.1200.7099Yes
102FGAFGA
Entrez,  Source
fibrinogen alpha chain14740.1150.7060Yes
103C3C3
Entrez,  Source
complement component 314750.1140.7091Yes
104ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain14800.1140.7119Yes
105BDH1BDH1
Entrez,  Source
3-hydroxybutyrate dehydrogenase, type 115740.1100.7078No
106DECR1DECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial15880.1090.7098No
107F12F12
Entrez,  Source
coagulation factor XII (Hageman factor)18080.1010.6959No
108AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)18590.0990.6948No
109PCBD1PCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)18700.0990.6967No
110PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 118970.0970.6973No
111CRHBPCRHBP
Entrez,  Source
corticotropin releasing hormone binding protein19100.0970.6991No
112CYP27A1CYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 120330.0930.6923No
113HGFACHGFAC
Entrez,  Source
HGF activator20740.0920.6917No
114GPTGPT
Entrez,  Source
glutamic-pyruvate transaminase (alanine aminotransferase)21460.0900.6888No
115APOC3APOC3
Entrez,  Source
apolipoprotein C-III21760.0890.6890No
116CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)21790.0890.6912No
117FGGFGG
Entrez,  Source
fibrinogen gamma chain22080.0880.6915No
118ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A122390.0870.6915No
119HPHP
Entrez,  Source
haptoglobin23210.0840.6877No
120FMO3FMO3
Entrez,  Source
flavin containing monooxygenase 323220.0840.6900No
121F2F2
Entrez,  Source
coagulation factor II (thrombin)23350.0840.6913No
122SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 123450.0840.6929No
123SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 224590.0810.6865No
124MST1MST1
Entrez,  Source
macrophage stimulating 1 (hepatocyte growth factor-like)25140.0790.6846No
125HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 426250.0760.6782No
126MGST1MGST1
Entrez,  Source
microsomal glutathione S-transferase 128880.0690.6602No
127AGTR1AGTR1
Entrez,  Source
angiotensin II receptor, type 129340.0680.6586No
128CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)29400.0680.6601No
129ITIH3ITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H331510.0630.6458No
130SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)33070.0600.6357No
131CPCP
Entrez,  Source
ceruloplasmin (ferroxidase)33490.0590.6342No
132SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 134050.0580.6315No
133PCCBPCCB
Entrez,  Source
propionyl Coenzyme A carboxylase, beta polypeptide34170.0580.6323No
134IL13RA1IL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 136740.0520.6142No
135ADH4ADH4
Entrez,  Source
alcohol dehydrogenase 4 (class II), pi polypeptide38000.0500.6061No
136SORDSORD
Entrez,  Source
sorbitol dehydrogenase39560.0470.5956No
137EPHX1EPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)41040.0450.5856No
138CPB2CPB2
Entrez,  Source
carboxypeptidase B2 (plasma, carboxypeptidase U)41450.0440.5837No
139APOA1APOA1
Entrez,  Source
apolipoprotein A-I41690.0430.5832No
140SEPP1SEPP1
Entrez,  Source
selenoprotein P, plasma, 141880.0430.5830No
141APCSAPCS
Entrez,  Source
amyloid P component, serum42010.0430.5832No
142HPDHPD
Entrez,  Source
4-hydroxyphenylpyruvate dioxygenase43830.0400.5705No
143HPXHPX
Entrez,  Source
hemopexin46800.0350.5490No
144CASC3CASC3
Entrez,  Source
cancer susceptibility candidate 347400.0340.5454No
145ORM1ORM1
Entrez,  Source
orosomucoid 148160.0320.5406No
146GGCXGGCX
Entrez,  Source
gamma-glutamyl carboxylase50190.0290.5260No
147GLUD1GLUD1
Entrez,  Source
glutamate dehydrogenase 150870.0280.5216No
148TOMM40TOMM40
Entrez,  Source
translocase of outer mitochondrial membrane 40 homolog (yeast)52280.0260.5117No
149CES2CES2
Entrez,  Source
carboxylesterase 2 (intestine, liver)54180.0230.4979No
150GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 154290.0230.4978No
151ADFPADFP
Entrez,  Source
adipose differentiation-related protein59010.0160.4624No
152PCK1PCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)60260.0140.4534No
153ALDH2ALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)61750.0120.4424No
154PROS1PROS1
Entrez,  Source
protein S (alpha)62440.0110.4375No
155AHSGAHSG
Entrez,  Source
alpha-2-HS-glycoprotein63540.0090.4295No
156CYP2C9CYP2C9
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 967530.0030.3993No
157SPP2SPP2
Entrez,  Source
secreted phosphoprotein 2, 24kDa67590.0030.3990No
158ALBALB
Entrez,  Source
albumin7095-0.0020.3736No
159FMO5FMO5
Entrez,  Source
flavin containing monooxygenase 57369-0.0060.3530No
160SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7883-0.0130.3143No
161SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 18105-0.0160.2980No
162ABCB4ABCB4
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 48306-0.0200.2833No
163PGRMC1PGRMC1
Entrez,  Source
progesterone receptor membrane component 18338-0.0200.2815No
164SDSSDS
Entrez,  Source
serine dehydratase8683-0.0260.2561No
165SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 18733-0.0270.2531No
166TAF6TAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa9493-0.0420.1965No
167LAMP2LAMP2
Entrez,  Source
lysosomal-associated membrane protein 29636-0.0440.1869No
168PRDX4PRDX4
Entrez,  Source
peroxiredoxin 410020-0.0530.1592No
169BZW1BZW1
Entrez,  Source
basic leucine zipper and W2 domains 110041-0.0530.1591No
170FN1FN1
Entrez,  Source
fibronectin 110062-0.0530.1590No
171CYP3A4CYP3A4
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 410311-0.0590.1418No
172IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta10379-0.0610.1383No
173LGALS4LGALS4
Entrez,  Source
lectin, galactoside-binding, soluble, 4 (galectin 4)10393-0.0610.1390No
174LSRLSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor10501-0.0640.1326No
175RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 410748-0.0710.1158No
176KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 210984-0.0780.1001No
177NAT2NAT2
Entrez,  Source
N-acetyltransferase 2 (arylamine N-acetyltransferase)10997-0.0780.1013No
178C2C2
Entrez,  Source
complement component 211048-0.0800.0997No
179IL13IL13
Entrez,  Source
interleukin 1311244-0.0880.0872No
180C1RC1R
Entrez,  Source
complement component 1, r subcomponent11480-0.0990.0720No
181GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)11580-0.1030.0673No
182RGL2RGL2
Entrez,  Source
ral guanine nucleotide dissociation stimulator-like 211681-0.1080.0626No
183HNMTHNMT
Entrez,  Source
histamine N-methyltransferase11747-0.1110.0607No
184ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 212020-0.1260.0434No
185RGNRGN
Entrez,  Source
regucalcin (senescence marker protein-30)12427-0.1610.0169No
186TM4SF4TM4SF4
Entrez,  Source
transmembrane 4 L six family member 412583-0.1820.0101No
187FSTFST
Entrez,  Source
follistatin13045-0.318-0.0164No
188SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 113125-0.378-0.0122No
189DAB2DAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)13152-0.403-0.0032No
190LIPCLIPC
Entrez,  Source
lipase, hepatic13275-0.6500.0051No
Table: GSEA details [plain text format]



Fig 2: HSIAO_LIVER_SPECIFIC_GENES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HSIAO_LIVER_SPECIFIC_GENES: Random ES distribution   
Gene set null distribution of ES for HSIAO_LIVER_SPECIFIC_GENES