Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | IRITANI_ADPROX_VASC |
| Enrichment Score (ES) | -0.6335416 |
| Normalized Enrichment Score (NES) | -2.1998954 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.642589E-4 |
| FWER p-Value | 0.0030 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 320 | 0.260 | -0.0055 | No |
| 2 | NRCAM | NRCAM Entrez, Source | neuronal cell adhesion molecule | 696 | 0.174 | -0.0214 | No |
| 3 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 1644 | 0.107 | -0.0852 | No |
| 4 | IL4R | IL4R Entrez, Source | interleukin 4 receptor | 1697 | 0.105 | -0.0816 | No |
| 5 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 1874 | 0.098 | -0.0878 | No |
| 6 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 1877 | 0.098 | -0.0809 | No |
| 7 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 1965 | 0.095 | -0.0807 | No |
| 8 | LYL1 | LYL1 Entrez, Source | lymphoblastic leukemia derived sequence 1 | 1977 | 0.095 | -0.0747 | No |
| 9 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 2131 | 0.090 | -0.0798 | No |
| 10 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 2189 | 0.088 | -0.0777 | No |
| 11 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 2338 | 0.084 | -0.0829 | No |
| 12 | FAP | FAP Entrez, Source | fibroblast activation protein, alpha | 2539 | 0.078 | -0.0923 | No |
| 13 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 2800 | 0.071 | -0.1069 | No |
| 14 | MAPKAPK3 | MAPKAPK3 Entrez, Source | mitogen-activated protein kinase-activated protein kinase 3 | 2853 | 0.070 | -0.1057 | No |
| 15 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 2893 | 0.069 | -0.1037 | No |
| 16 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 2940 | 0.068 | -0.1023 | No |
| 17 | ANPEP | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 3631 | 0.053 | -0.1506 | No |
| 18 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 3728 | 0.051 | -0.1542 | No |
| 19 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3781 | 0.050 | -0.1545 | No |
| 20 | CTSC | CTSC Entrez, Source | cathepsin C | 3796 | 0.050 | -0.1520 | No |
| 21 | SELP | SELP Entrez, Source | selectin P (granule membrane protein 140kDa, antigen CD62) | 3948 | 0.047 | -0.1600 | No |
| 22 | SORD | SORD Entrez, Source | sorbitol dehydrogenase | 3956 | 0.047 | -0.1571 | No |
| 23 | UPP1 | UPP1 Entrez, Source | uridine phosphorylase 1 | 4127 | 0.044 | -0.1668 | No |
| 24 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 4357 | 0.040 | -0.1812 | No |
| 25 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 4648 | 0.035 | -0.2006 | No |
| 26 | SELE | SELE Entrez, Source | selectin E (endothelial adhesion molecule 1) | 4846 | 0.032 | -0.2132 | No |
| 27 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 4920 | 0.030 | -0.2165 | No |
| 28 | TXNRD2 | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 5055 | 0.028 | -0.2246 | No |
| 29 | MT1A | MT1A Entrez, Source | metallothionein 1A (functional) | 5078 | 0.028 | -0.2242 | No |
| 30 | BGN | BGN Entrez, Source | biglycan | 5847 | 0.017 | -0.2810 | No |
| 31 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 6072 | 0.013 | -0.2970 | No |
| 32 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6175 | 0.012 | -0.3039 | No |
| 33 | LTBP2 | LTBP2 Entrez, Source | latent transforming growth factor beta binding protein 2 | 6275 | 0.010 | -0.3106 | No |
| 34 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 6332 | 0.009 | -0.3142 | No |
| 35 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 6461 | 0.007 | -0.3234 | No |
| 36 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 6817 | 0.002 | -0.3500 | No |
| 37 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 7239 | -0.004 | -0.3815 | No |
| 38 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 7382 | -0.006 | -0.3918 | No |
| 39 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 7404 | -0.006 | -0.3930 | No |
| 40 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 7411 | -0.006 | -0.3930 | No |
| 41 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 7492 | -0.007 | -0.3985 | No |
| 42 | SRPX | SRPX Entrez, Source | sushi-repeat-containing protein, X-linked | 7631 | -0.010 | -0.4083 | No |
| 43 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 8051 | -0.016 | -0.4388 | No |
| 44 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 8308 | -0.020 | -0.4567 | No |
| 45 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.4560 | No |
| 46 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 8404 | -0.021 | -0.4608 | No |
| 47 | LPXN | LPXN Entrez, Source | leupaxin | 8598 | -0.025 | -0.4736 | No |
| 48 | ANXA6 | ANXA6 Entrez, Source | annexin A6 | 9062 | -0.033 | -0.5062 | No |
| 49 | PFN2 | PFN2 Entrez, Source | profilin 2 | 9269 | -0.037 | -0.5191 | No |
| 50 | MVP | MVP Entrez, Source | major vault protein | 9306 | -0.038 | -0.5191 | No |
| 51 | IER3 | IER3 Entrez, Source | immediate early response 3 | 9311 | -0.038 | -0.5166 | No |
| 52 | SLC1A1 | SLC1A1 Entrez, Source | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 9452 | -0.041 | -0.5243 | No |
| 53 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 9459 | -0.041 | -0.5218 | No |
| 54 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 9636 | -0.044 | -0.5319 | No |
| 55 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 9737 | -0.046 | -0.5361 | No |
| 56 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9946 | -0.051 | -0.5482 | No |
| 57 | ICAM2 | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 10161 | -0.056 | -0.5604 | No |
| 58 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 10171 | -0.056 | -0.5570 | No |
| 59 | EIF2B2 | EIF2B2 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | 10173 | -0.056 | -0.5531 | No |
| 60 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 10391 | -0.061 | -0.5651 | No |
| 61 | PKIA | PKIA Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 10441 | -0.063 | -0.5643 | No |
| 62 | TFEC | TFEC Entrez, Source | transcription factor EC | 10663 | -0.069 | -0.5760 | No |
| 63 | CHST1 | CHST1 Entrez, Source | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 10942 | -0.077 | -0.5915 | No |
| 64 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 11339 | -0.092 | -0.6148 | No |
| 65 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 11588 | -0.104 | -0.6261 | Yes |
| 66 | TCN2 | TCN2 Entrez, Source | transcobalamin II; macrocytic anemia | 11593 | -0.104 | -0.6190 | Yes |
| 67 | JUN | JUN Entrez, Source | jun oncogene | 11756 | -0.111 | -0.6232 | Yes |
| 68 | AGRIN | AGRIN Entrez, Source | agrin | 11810 | -0.114 | -0.6190 | Yes |
| 69 | SLC6A8 | SLC6A8 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 11820 | -0.115 | -0.6115 | Yes |
| 70 | CLU | CLU Entrez, Source | clusterin | 12046 | -0.128 | -0.6193 | Yes |
| 71 | SLC38A6 | SLC38A6 Entrez, Source | solute carrier family 38, member 6 | 12082 | -0.130 | -0.6126 | Yes |
| 72 | UCHL1 | UCHL1 Entrez, Source | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 12088 | -0.130 | -0.6036 | Yes |
| 73 | RGS10 | RGS10 Entrez, Source | regulator of G-protein signalling 10 | 12133 | -0.133 | -0.5974 | Yes |
| 74 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 12172 | -0.136 | -0.5904 | Yes |
| 75 | MLLT11 | MLLT11 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 12260 | -0.145 | -0.5866 | Yes |
| 76 | NISCH | NISCH Entrez, Source | nischarin | 12301 | -0.148 | -0.5790 | Yes |
| 77 | PLA2G4A | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 12414 | -0.160 | -0.5760 | Yes |
| 78 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 12491 | -0.169 | -0.5696 | Yes |
| 79 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12537 | -0.177 | -0.5603 | Yes |
| 80 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 12546 | -0.178 | -0.5481 | Yes |
| 81 | ARL6IP5 | ARL6IP5 Entrez, Source | ADP-ribosylation-like factor 6 interacting protein 5 | 12549 | -0.178 | -0.5355 | Yes |
| 82 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 12592 | -0.184 | -0.5255 | Yes |
| 83 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 12629 | -0.189 | -0.5146 | Yes |
| 84 | NMT2 | NMT2 Entrez, Source | N-myristoyltransferase 2 | 12660 | -0.196 | -0.5028 | Yes |
| 85 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12697 | -0.204 | -0.4908 | Yes |
| 86 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 12804 | -0.226 | -0.4826 | Yes |
| 87 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 12818 | -0.229 | -0.4672 | Yes |
| 88 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 13011 | -0.297 | -0.4604 | Yes |
| 89 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 13034 | -0.309 | -0.4399 | Yes |
| 90 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 13038 | -0.313 | -0.4176 | Yes |
| 91 | ANXA3 | ANXA3 Entrez, Source | annexin A3 | 13069 | -0.331 | -0.3962 | Yes |
| 92 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 13112 | -0.366 | -0.3731 | Yes |
| 93 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13125 | -0.378 | -0.3469 | Yes |
| 94 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 13174 | -0.431 | -0.3195 | Yes |
| 95 | PROCR | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 13212 | -0.481 | -0.2878 | Yes |
| 96 | FHL2 | FHL2 Entrez, Source | four and a half LIM domains 2 | 13229 | -0.509 | -0.2525 | Yes |
| 97 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13264 | -0.594 | -0.2124 | Yes |
| 98 | GBP2 | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 13270 | -0.639 | -0.1669 | Yes |
| 99 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13317 | -0.925 | -0.1040 | Yes |
| 100 | TAGLN | TAGLN Entrez, Source | transgelin | 13339 | -1.475 | 0.0002 | Yes |
