Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | LH_GRANULOSA_DN |
| Enrichment Score (ES) | -0.6009744 |
| Normalized Enrichment Score (NES) | -1.7657591 |
| Nominal p-value | 0.0017482517 |
| FDR q-value | 0.042123154 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RGS5 | RGS5 Entrez, Source | regulator of G-protein signalling 5 | 256 | 0.285 | 0.0264 | No |
| 2 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 717 | 0.171 | 0.0192 | No |
| 3 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 1014 | 0.144 | 0.0198 | No |
| 4 | MAPK14 | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 1814 | 0.101 | -0.0241 | No |
| 5 | CASP4 | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 2168 | 0.089 | -0.0364 | No |
| 6 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 2353 | 0.084 | -0.0369 | No |
| 7 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 2579 | 0.077 | -0.0415 | No |
| 8 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 3416 | 0.058 | -0.0951 | No |
| 9 | PRKD1 | PRKD1 Entrez, Source | protein kinase D1 | 3605 | 0.054 | -0.1007 | No |
| 10 | RANGAP1 | RANGAP1 Entrez, Source | Ran GTPase activating protein 1 | 4842 | 0.032 | -0.1885 | No |
| 11 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 4920 | 0.030 | -0.1894 | No |
| 12 | AKAP12 | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 5319 | 0.024 | -0.2155 | No |
| 13 | MAPK6 | MAPK6 Entrez, Source | mitogen-activated protein kinase 6 | 5856 | 0.016 | -0.2531 | No |
| 14 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.2738 | No |
| 15 | BECN1 | BECN1 Entrez, Source | beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) | 6675 | 0.004 | -0.3119 | No |
| 16 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 8308 | -0.020 | -0.4315 | No |
| 17 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 8404 | -0.021 | -0.4352 | No |
| 18 | SMARCA4 | SMARCA4 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 8494 | -0.023 | -0.4382 | No |
| 19 | PTPRE | PTPRE Entrez, Source | protein tyrosine phosphatase, receptor type, E | 8704 | -0.026 | -0.4497 | No |
| 20 | ATP2A2 | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 9784 | -0.048 | -0.5232 | No |
| 21 | MAP2K3 | MAP2K3 Entrez, Source | mitogen-activated protein kinase kinase 3 | 9785 | -0.048 | -0.5156 | No |
| 22 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10008 | -0.052 | -0.5240 | No |
| 23 | PLCL1 | PLCL1 Entrez, Source | phospholipase C-like 1 | 10259 | -0.058 | -0.5335 | No |
| 24 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 10391 | -0.061 | -0.5336 | No |
| 25 | TRIB1 | TRIB1 Entrez, Source | tribbles homolog 1 (Drosophila) | 10667 | -0.069 | -0.5433 | No |
| 26 | DYRK3 | DYRK3 Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 10779 | -0.072 | -0.5401 | No |
| 27 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 11055 | -0.080 | -0.5479 | No |
| 28 | ACTG2 | ACTG2 Entrez, Source | actin, gamma 2, smooth muscle, enteric | 11475 | -0.099 | -0.5637 | No |
| 29 | KIDINS220 | KIDINS220 Entrez, Source | - | 11972 | -0.123 | -0.5813 | Yes |
| 30 | TLN1 | TLN1 Entrez, Source | talin 1 | 12039 | -0.127 | -0.5659 | Yes |
| 31 | NPC2 | NPC2 Entrez, Source | Niemann-Pick disease, type C2 | 12096 | -0.131 | -0.5492 | Yes |
| 32 | PAWR | PAWR Entrez, Source | PRKC, apoptosis, WT1, regulator | 12264 | -0.145 | -0.5386 | Yes |
| 33 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 12267 | -0.145 | -0.5155 | Yes |
| 34 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12537 | -0.177 | -0.5075 | Yes |
| 35 | ARL6IP5 | ARL6IP5 Entrez, Source | ADP-ribosylation-like factor 6 interacting protein 5 | 12549 | -0.178 | -0.4798 | Yes |
| 36 | PPP3R1 | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 12578 | -0.181 | -0.4530 | Yes |
| 37 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 12682 | -0.201 | -0.4287 | Yes |
| 38 | TYRO3 | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 12984 | -0.284 | -0.4059 | Yes |
| 39 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13200 | -0.467 | -0.3474 | Yes |
| 40 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13279 | -0.655 | -0.2486 | Yes |
| 41 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.586 | 0.0002 | Yes |
