Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | LIGASE_ACTIVITY |
| Enrichment Score (ES) | 0.5077989 |
| Normalized Enrichment Score (NES) | 1.6537085 |
| Nominal p-value | 0.006849315 |
| FDR q-value | 0.05154639 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SLC27A5 | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 9 | 0.779 | 0.1704 | Yes |
| 2 | PC | PC Entrez, Source | pyruvate carboxylase | 155 | 0.347 | 0.2358 | Yes |
| 3 | ACACA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 231 | 0.293 | 0.2945 | Yes |
| 4 | CPS1 | CPS1 Entrez, Source | carbamoyl-phosphate synthetase 1, mitochondrial | 292 | 0.268 | 0.3488 | Yes |
| 5 | MTHFD1 | MTHFD1 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 405 | 0.229 | 0.3907 | Yes |
| 6 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 609 | 0.185 | 0.4161 | Yes |
| 7 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 823 | 0.160 | 0.4353 | Yes |
| 8 | YARS | YARS Entrez, Source | tyrosyl-tRNA synthetase | 984 | 0.146 | 0.4554 | Yes |
| 9 | TRIM23 | TRIM23 Entrez, Source | tripartite motif-containing 23 | 1245 | 0.127 | 0.4638 | Yes |
| 10 | PARK2 | PARK2 Entrez, Source | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 1812 | 0.101 | 0.4434 | Yes |
| 11 | GCLM | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 1840 | 0.100 | 0.4632 | Yes |
| 12 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 1864 | 0.099 | 0.4832 | Yes |
| 13 | SYVN1 | SYVN1 Entrez, Source | synovial apoptosis inhibitor 1, synoviolin | 2057 | 0.092 | 0.4891 | Yes |
| 14 | FBXO7 | FBXO7 Entrez, Source | F-box protein 7 | 2304 | 0.085 | 0.4892 | Yes |
| 15 | WWP1 | WWP1 Entrez, Source | WW domain containing E3 ubiquitin protein ligase 1 | 2306 | 0.085 | 0.5078 | Yes |
| 16 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 3384 | 0.058 | 0.4397 | No |
| 17 | PCCB | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 3417 | 0.058 | 0.4499 | No |
| 18 | GMPS | GMPS Entrez, Source | guanine monphosphate synthetase | 3595 | 0.054 | 0.4484 | No |
| 19 | ACSL4 | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 3612 | 0.053 | 0.4590 | No |
| 20 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 3662 | 0.053 | 0.4669 | No |
| 21 | FBXO22 | FBXO22 Entrez, Source | F-box protein 22 | 3983 | 0.047 | 0.4531 | No |
| 22 | GSS | GSS Entrez, Source | glutathione synthetase | 4011 | 0.046 | 0.4612 | No |
| 23 | ASNS | ASNS Entrez, Source | asparagine synthetase | 4245 | 0.042 | 0.4529 | No |
| 24 | GARS | GARS Entrez, Source | glycyl-tRNA synthetase | 4370 | 0.040 | 0.4524 | No |
| 25 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 4616 | 0.036 | 0.4418 | No |
| 26 | BTD | BTD Entrez, Source | biotinidase | 4657 | 0.035 | 0.4465 | No |
| 27 | NARS | NARS Entrez, Source | asparaginyl-tRNA synthetase | 5426 | 0.023 | 0.3938 | No |
| 28 | CTPS2 | CTPS2 Entrez, Source | CTP synthase II | 5705 | 0.019 | 0.3770 | No |
| 29 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 6478 | 0.007 | 0.3204 | No |
| 30 | KARS | KARS Entrez, Source | lysyl-tRNA synthetase | 7266 | -0.004 | 0.2621 | No |
| 31 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 7556 | -0.008 | 0.2422 | No |
| 32 | PAICS | PAICS Entrez, Source | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 8385 | -0.021 | 0.1846 | No |
| 33 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 8548 | -0.024 | 0.1777 | No |
| 34 | RTCD1 | RTCD1 Entrez, Source | RNA terminal phosphate cyclase domain 1 | 9183 | -0.035 | 0.1378 | No |
| 35 | FARS2 | FARS2 Entrez, Source | phenylalanine-tRNA synthetase 2 (mitochondrial) | 9209 | -0.036 | 0.1438 | No |
| 36 | ARIH1 | ARIH1 Entrez, Source | ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) | 9532 | -0.042 | 0.1288 | No |
| 37 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 10467 | -0.063 | 0.0726 | No |
| 38 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 10523 | -0.065 | 0.0826 | No |
| 39 | XRCC4 | XRCC4 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 4 | 11084 | -0.081 | 0.0584 | No |
| 40 | FBXO2 | FBXO2 Entrez, Source | F-box protein 2 | 11601 | -0.104 | 0.0425 | No |
| 41 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 11637 | -0.106 | 0.0632 | No |
| 42 | ANAPC2 | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 11844 | -0.116 | 0.0733 | No |
| 43 | FBXL6 | FBXL6 Entrez, Source | F-box and leucine-rich repeat protein 6 | 12552 | -0.179 | 0.0594 | No |
