Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | LIPID_BIOSYNTHETIC_PROCESS |
| Enrichment Score (ES) | 0.46548158 |
| Normalized Enrichment Score (NES) | 1.5705893 |
| Nominal p-value | 0.0072289156 |
| FDR q-value | 0.078949966 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PEMT | PEMT Entrez, Source | phosphatidylethanolamine N-methyltransferase | 8 | 0.798 | 0.1188 | Yes |
| 2 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 136 | 0.372 | 0.1650 | Yes |
| 3 | LCAT | LCAT Entrez, Source | lecithin-cholesterol acyltransferase | 142 | 0.365 | 0.2193 | Yes |
| 4 | FADS2 | FADS2 Entrez, Source | fatty acid desaturase 2 | 182 | 0.324 | 0.2649 | Yes |
| 5 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 462 | 0.212 | 0.2757 | Yes |
| 6 | DGAT2 | DGAT2 Entrez, Source | diacylglycerol O-acyltransferase homolog 2 (mouse) | 503 | 0.201 | 0.3028 | Yes |
| 7 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 578 | 0.188 | 0.3255 | Yes |
| 8 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 685 | 0.175 | 0.3437 | Yes |
| 9 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 693 | 0.174 | 0.3692 | Yes |
| 10 | PCYT2 | PCYT2 Entrez, Source | phosphate cytidylyltransferase 2, ethanolamine | 748 | 0.168 | 0.3902 | Yes |
| 11 | CHPT1 | CHPT1 Entrez, Source | choline phosphotransferase 1 | 778 | 0.165 | 0.4126 | Yes |
| 12 | ST8SIA1 | ST8SIA1 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 1223 | 0.128 | 0.3984 | Yes |
| 13 | PI4K2A | 1329 | 0.123 | 0.4088 | Yes | ||
| 14 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1370 | 0.121 | 0.4239 | Yes |
| 15 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 1495 | 0.114 | 0.4315 | Yes |
| 16 | CD74 | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 1524 | 0.112 | 0.4462 | Yes |
| 17 | SCP2 | SCP2 Entrez, Source | sterol carrier protein 2 | 1632 | 0.107 | 0.4542 | Yes |
| 18 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 1859 | 0.099 | 0.4520 | Yes |
| 19 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 1877 | 0.098 | 0.4655 | Yes |
| 20 | ST6GALNAC6 | ST6GALNAC6 Entrez, Source | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | 2672 | 0.074 | 0.4168 | No |
| 21 | PEX7 | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 3029 | 0.066 | 0.3999 | No |
| 22 | ST8SIA5 | ST8SIA5 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 | 3625 | 0.053 | 0.3631 | No |
| 23 | PIGK | PIGK Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class K | 3814 | 0.050 | 0.3564 | No |
| 24 | AGPAT1 | AGPAT1 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) | 4028 | 0.046 | 0.3472 | No |
| 25 | APOA1 | APOA1 Entrez, Source | apolipoprotein A-I | 4169 | 0.043 | 0.3432 | No |
| 26 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 4326 | 0.041 | 0.3375 | No |
| 27 | PIGC | PIGC Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class C | 4338 | 0.040 | 0.3428 | No |
| 28 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 4542 | 0.037 | 0.3330 | No |
| 29 | HPGD | HPGD Entrez, Source | hydroxyprostaglandin dehydrogenase 15-(NAD) | 4803 | 0.032 | 0.3183 | No |
| 30 | PTGS1 | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 4887 | 0.031 | 0.3167 | No |
| 31 | HSD3B1 | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 4997 | 0.029 | 0.3129 | No |
| 32 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 5438 | 0.023 | 0.2832 | No |
| 33 | AGPS | AGPS Entrez, Source | alkylglycerone phosphate synthase | 6079 | 0.013 | 0.2370 | No |
| 34 | PCYT1B | PCYT1B Entrez, Source | phosphate cytidylyltransferase 1, choline, beta | 6186 | 0.012 | 0.2307 | No |
| 35 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 6391 | 0.008 | 0.2166 | No |
| 36 | ST8SIA3 | ST8SIA3 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | 6457 | 0.007 | 0.2127 | No |
| 37 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 6596 | 0.005 | 0.2031 | No |
| 38 | PTGDS | PTGDS Entrez, Source | prostaglandin D2 synthase 21kDa (brain) | 6738 | 0.003 | 0.1930 | No |
| 39 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7883 | -0.013 | 0.1089 | No |
| 40 | PIGV | PIGV Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class V | 7912 | -0.014 | 0.1089 | No |
| 41 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 8089 | -0.016 | 0.0980 | No |
| 42 | DPM2 | DPM2 Entrez, Source | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit | 8478 | -0.023 | 0.0722 | No |
| 43 | CYP7B1 | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 9114 | -0.034 | 0.0296 | No |
| 44 | PIGS | PIGS Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class S | 9263 | -0.037 | 0.0240 | No |
| 45 | MIF | MIF Entrez, Source | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 9316 | -0.038 | 0.0258 | No |
| 46 | NR0B1 | NR0B1 Entrez, Source | nuclear receptor subfamily 0, group B, member 1 | 9783 | -0.047 | -0.0022 | No |
| 47 | IMPA1 | IMPA1 Entrez, Source | inositol(myo)-1(or 4)-monophosphatase 1 | 9804 | -0.048 | 0.0035 | No |
| 48 | CYP11A1 | CYP11A1 Entrez, Source | cytochrome P450, family 11, subfamily A, polypeptide 1 | 10102 | -0.054 | -0.0107 | No |
| 49 | LTA4H | LTA4H Entrez, Source | leukotriene A4 hydrolase | 10430 | -0.062 | -0.0260 | No |
| 50 | CD81 | CD81 Entrez, Source | CD81 molecule | 11022 | -0.079 | -0.0586 | No |
| 51 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 11324 | -0.092 | -0.0675 | No |
| 52 | AGPAT6 | AGPAT6 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) | 12308 | -0.149 | -0.1192 | No |
| 53 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 12906 | -0.254 | -0.1261 | No |
| 54 | PLCE1 | PLCE1 Entrez, Source | phospholipase C, epsilon 1 | 13110 | -0.363 | -0.0869 | No |
| 55 | ADM | ADM Entrez, Source | adrenomedullin | 13287 | -0.697 | 0.0041 | No |
