Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | MANALO_HYPOXIA_UP |
| Enrichment Score (ES) | -0.51987034 |
| Normalized Enrichment Score (NES) | -1.7033118 |
| Nominal p-value | 0.0065789474 |
| FDR q-value | 0.06252876 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LEPR | LEPR Entrez, Source | leptin receptor | 146 | 0.357 | 0.0290 | No |
| 2 | ANGPTL4 | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 251 | 0.287 | 0.0533 | No |
| 3 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 613 | 0.184 | 0.0468 | No |
| 4 | INSR | INSR Entrez, Source | insulin receptor | 735 | 0.169 | 0.0566 | No |
| 5 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 901 | 0.153 | 0.0612 | No |
| 6 | GDF10 | GDF10 Entrez, Source | growth differentiation factor 10 | 926 | 0.151 | 0.0763 | No |
| 7 | PTGIS | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 1288 | 0.125 | 0.0631 | No |
| 8 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1856 | 0.099 | 0.0315 | No |
| 9 | RGS3 | RGS3 Entrez, Source | regulator of G-protein signalling 3 | 1991 | 0.094 | 0.0320 | No |
| 10 | HES1 | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 2287 | 0.085 | 0.0193 | No |
| 11 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 2436 | 0.082 | 0.0173 | No |
| 12 | GRK5 | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 2743 | 0.073 | 0.0024 | No |
| 13 | RLN1 | RLN1 Entrez, Source | relaxin 1 | 2849 | 0.070 | 0.0023 | No |
| 14 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 2940 | 0.068 | 0.0032 | No |
| 15 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 3018 | 0.066 | 0.0048 | No |
| 16 | SHOX2 | SHOX2 Entrez, Source | short stature homeobox 2 | 3329 | 0.059 | -0.0119 | No |
| 17 | PPARG | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 3592 | 0.054 | -0.0256 | No |
| 18 | NOTCH4 | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 3695 | 0.052 | -0.0275 | No |
| 19 | ADORA2A | ADORA2A Entrez, Source | adenosine A2a receptor | 4439 | 0.039 | -0.0791 | No |
| 20 | PTGS1 | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 4887 | 0.031 | -0.1093 | No |
| 21 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 5082 | 0.028 | -0.1208 | No |
| 22 | CUBN | CUBN Entrez, Source | cubilin (intrinsic factor-cobalamin receptor) | 5212 | 0.026 | -0.1276 | No |
| 23 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 5540 | 0.021 | -0.1498 | No |
| 24 | PTPRR | PTPRR Entrez, Source | protein tyrosine phosphatase, receptor type, R | 5645 | 0.020 | -0.1555 | No |
| 25 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 6072 | 0.013 | -0.1861 | No |
| 26 | EPOR | EPOR Entrez, Source | erythropoietin receptor | 6541 | 0.006 | -0.2207 | No |
| 27 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 6984 | -0.000 | -0.2540 | No |
| 28 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 7132 | -0.002 | -0.2648 | No |
| 29 | ITPR2 | ITPR2 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 2 | 7164 | -0.003 | -0.2668 | No |
| 30 | ENPP1 | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 7834 | -0.013 | -0.3158 | No |
| 31 | NFATC4 | NFATC4 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 7871 | -0.013 | -0.3170 | No |
| 32 | EGLN1 | EGLN1 Entrez, Source | egl nine homolog 1 (C. elegans) | 8000 | -0.015 | -0.3250 | No |
| 33 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 8051 | -0.016 | -0.3270 | No |
| 34 | NPR1 | NPR1 Entrez, Source | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) | 8241 | -0.019 | -0.3391 | No |
| 35 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 8284 | -0.020 | -0.3401 | No |
| 36 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 8404 | -0.021 | -0.3467 | No |
| 37 | ERO1L | ERO1L Entrez, Source | ERO1-like (S. cerevisiae) | 8926 | -0.031 | -0.3825 | No |
| 38 | HIF3A | HIF3A Entrez, Source | hypoxia inducible factor 3, alpha subunit | 9307 | -0.038 | -0.4069 | No |
| 39 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 9737 | -0.046 | -0.4340 | No |
| 40 | PLCG2 | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 9827 | -0.048 | -0.4352 | No |
| 41 | COL9A1 | COL9A1 Entrez, Source | collagen, type IX, alpha 1 | 9874 | -0.049 | -0.4332 | No |
| 42 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 9949 | -0.051 | -0.4331 | No |
| 43 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10008 | -0.052 | -0.4316 | No |
| 44 | HIVEP2 | HIVEP2 Entrez, Source | human immunodeficiency virus type I enhancer binding protein 2 | 10603 | -0.067 | -0.4688 | No |
| 45 | ZBTB1 | ZBTB1 Entrez, Source | zinc finger and BTB domain containing 1 | 10948 | -0.077 | -0.4861 | No |
| 46 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 10974 | -0.078 | -0.4793 | No |
| 47 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 11428 | -0.096 | -0.5026 | No |
| 48 | TCF8 | TCF8 Entrez, Source | transcription factor 8 (represses interleukin 2 expression) | 11658 | -0.107 | -0.5079 | Yes |
| 49 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 11745 | -0.111 | -0.5019 | Yes |
| 50 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 11795 | -0.113 | -0.4929 | Yes |
| 51 | FKBP9 | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 11975 | -0.123 | -0.4926 | Yes |
| 52 | PTPRF | PTPRF Entrez, Source | protein tyrosine phosphatase, receptor type, F | 12127 | -0.133 | -0.4890 | Yes |
| 53 | CASK | CASK Entrez, Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 12154 | -0.135 | -0.4759 | Yes |
| 54 | VLDLR | VLDLR Entrez, Source | very low density lipoprotein receptor | 12472 | -0.167 | -0.4811 | Yes |
| 55 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 12570 | -0.180 | -0.4682 | Yes |
| 56 | TNFRSF14 | TNFRSF14 Entrez, Source | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 12572 | -0.181 | -0.4480 | Yes |
| 57 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12697 | -0.204 | -0.4345 | Yes |
| 58 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 12699 | -0.205 | -0.4116 | Yes |
| 59 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 12803 | -0.226 | -0.3941 | Yes |
| 60 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 12937 | -0.264 | -0.3745 | Yes |
| 61 | TRIO | TRIO Entrez, Source | triple functional domain (PTPRF interacting) | 12955 | -0.274 | -0.3451 | Yes |
| 62 | ZNF292 | ZNF292 Entrez, Source | zinc finger protein 292 | 13006 | -0.293 | -0.3160 | Yes |
| 63 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13160 | -0.412 | -0.2813 | Yes |
| 64 | EDN1 | EDN1 Entrez, Source | endothelin 1 | 13172 | -0.431 | -0.2339 | Yes |
| 65 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13266 | -0.607 | -0.1729 | Yes |
| 66 | ADM | ADM Entrez, Source | adrenomedullin | 13287 | -0.697 | -0.0963 | Yes |
| 67 | LOX | LOX Entrez, Source | lysyl oxidase | 13315 | -0.896 | 0.0020 | Yes |
